PBL 1 Flashcards

1
Q

what is glaucoma?

A

a group of eye diseases caused by intraocular hypertension which can damage the optic nerve and, if left untreated, can lead to blindness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

at what age is glaucoma most common?

A

between 70s and 80s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is considred a high intraocular pressure?

A

> 21mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the 2 causes of increased intraocular pressure?

A

blocking of the aqueous humor drainage pathway or an increased aqueous humor production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are symptoms of glaucoma?

A

peripheral vision loss
blurred vision
seeing rainbow coloured circles around bright lights

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are risk factors for glaucoma?

A
raised intraocular pressure
being >60
family history
being black, asian or hispanic
corticosteroid use
myopia (short sightedness)
type 2 diabetes
hypertension
CVD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how is glaucoma diagnosed?

A

tonometry - assess intraocular pressure
visual field testing
imaging or directly observing for optic nerve damage (often see cupping of the optic nerve)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

why do we often see cupping of the optic nerve in glaucoma?

A

as we get thinning of the outer rim of the nerve, givving it a cup shape

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the 5 types of glaucoma?

A
open angle
closed angle
normal tension
secondary
congenital
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is congenital glaucoma?

A

a developmental glaucoma occurring before the age of three years due to an obstruction that prevents adequate drainage of aqueous humor caused by abnormal development of the trabecular meshwork (TM) and anterior chamber angle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are some underlying eye conditions that can cause secondary glaucoma?

A

steroid use, eye injury, uveitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is normal tension glaucoma?

A

a form of glaucoma in which damage occurs to the optic nerve without eye pressure exceeding the normal range.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is considered a normal pressure rnage for intraocular pressure?

A

12-22 mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is open angle glaucoma?

A

when the angle of the anterior chamber is open but the drainage system slowly becomes clogged over time so we get a gradual increase in intraocular pressure and therefore gradual damage to the optic nerve. This begins as atrophy of the outer rim of the nerve causing a decrease in peripheral vision but as pressre increases we get continued damage which eventually will lead to a loss of central vision too

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is closed angle glaucoma?

A

when the angle of the anterior chamber is too small so the aqueous humor outflow path is too narrow which leads to a rapid build up of pressure in the eye which can cause an abrupt onset of symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are symptoms of closed angle glaucoma?

A

abrupt onset of…

severe eye pain, eye redness, blurry vision, headaches, nausea, visual haloes, vision loss

17
Q

outline the role of the autonomic nervous system on the intraocular pressure?

A

the parasympathetic system causes pupillary constriction, decreasing intraocular pressure
sympathetic system causes pupillary dilation which increases intraocular pressure

18
Q

what are the 3 main treatment options for glaucoma?

A

topical prostaglandin analogues
topical beta blockers
carbonic anhydrase inhibitors

19
Q

what are the 3 main treatment options for glaucoma?

A

topical prostaglandin analogues
topical beta blockers
carbonic anhydrase inhibitors h

19
Q

what are the 3 main treatment options for glaucoma?

A

topical prostaglandin analogues
topical beta blockers
carbonic anhydrase inhibitors h

20
Q

how do prostaglandin analogues work to treat glaucoma?

A

they increase the outflow of aqueous humor, decreasing intraocular pressure

21
Q

what are side effects of topical prostaglandin analogues?

A

burning in eyes
darkening of eyelids
blurred vision

22
Q

how do topical beta blockers work to treat glaucoma?

A

they decrease aqueous humor production by blocking adneylyl cyclase

23
Q

how do carbonic anhydrase inhibitors work to treat glaucoma?

A

inhibiting CA causes decreases HCO3- production which leads to a decreased aqueous humor production

24
Q

what are examples of topic prostaglandin analogues used in glaucoma?

A

latanoprost
travoprost
bimatoprost
tafluprost

25
Q

what are examples of topical beta blockers used in glaucoma?

A

betaxolol
levobunolol
hydrochloride
timolol maleate

26
Q

what are examples of carbonic anhydrase inhibitors used to treat glaucoma?

A

brinzolamide and dorzolamide

27
Q

what are side effects of topical beta blockers?

A

hypotension
difficulty breathing
bradycardia

28
Q

what are side effects of carbonic anhdrase inhibitors?

A

burning in eyes
metallic taste
increased urination

29
Q

what are some non-medication treatment options for glaucoma?

A

laser treatments e.g. trabeculoplasty, iridotomy, destroying humor-producing cells, creating a new aqueous humor exit route
implants to shunt fluid from anterior chamber bypassing trabecular meshwork ans collecting system

30
Q

what is a trabeculoplasty?

A

laser surgery that opens trabecular mesh netwrok

31
Q

what is an iridotomy?

A

laser treatment that punches a small hole in the iris

32
Q

what laser treatment is used to treat open angle glaucoma?

A

trabeculoplasty

33
Q

what laser treatment is used to treat closed angle glaucoma

A

iridotomy