Pattys eukaryotic gene expression lecture 5 Flashcards
1
Q
What is defective in reginitis pigmentosa
A
U4,U5,U6
2
Q
What is defective in musuclar dystrophy
A
U1 u2 u4 u5 u6
3
Q
What attacks the donor site
A
Un paired A site via its 2’ OH
4
Q
Where do each of the snRNPs bind
A
U1 to Gu donor sitre
u2 to unpaired A
U2af to pyrimine rich region
U4u5u6 to u1 once a complex has formed
5
Q
What is the donor site sequence
A
GU
6
Q
What is the acceptor splice site sequence
A
AG
7
Q
Which snRNPs exit to form the c complex
A
U1 and U4
