Patterns Of Inheritance Flashcards
Genotype
The genetic makeup of an organism
Phenotype
The characteristics observed when the genotype interacts with the environment
Allele
Variations of genes which arise through mutation
Carrier
An organism which can pass an inherited genetic disease onto their children but are not affected by the disease
Heterozygous
Contains two different alleles
Homozygous
Contains two of the same alleles
Dominant
Only requires one for the characteristic to be expressed
Recessive
Requires all alleles to be recessive to express the gene
Huntington’s disease
Huntington’s disease is a condition that damages nerve cells in the brain causing them to stop working properly. It’s passed on (inherited) from a person’s parents. The damage to the brain gets worse over time. It can affect movement, cognition (perception, awareness, thinking, judgement) and mental health.
Cystic fibrosis
a hereditary disorder affecting the exocrine glands. It causes the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines, and bronchi and often resulting in respiratory infection
How can meiosis bring about genetic variation
Random arrangement of chromosomes during lineup
Crossing over of chromatids before the first division
How does random fertilisation bring about genetic variation
Gametes are haploid cells, meaning they only contain half of a persons DNA. As this is determined by meiosis, every gamete contains different DNA. Therefore the same two individuals can produce genetically different offspring
Define monogenic inheritance
Where one phenotype characteristic is controlled by a single gene
Draw a genetic diagram for monogenic inheritance
Parental phenotypes = Brown eyes, Blue eyes
Parental genotypes = Bb, bb
Gametes = B, b and b, b
Offspring genotypes = Bb, Bb, bb, bb
Offspring phenotypes = 2:2 brown eyes : blue eyes
Define dihybrid inheritance
Where two phenotypic characteristics are determined by two different genes present on two different chromosomes at the same time
Draw a genetic diagram for dihybrid inheritance
Parental phenotypes = Round yellow seeds, Wrinkled green seeds
Parental genotypes = RRYY and rryy
Gamates = RY, RY and ry, ry
Offspring genotypes = RrYy
Offspring phenotypes = Round yellow seeds
What is meant by sex-linkage
Where an allele is located on one of the sex chromasomes, meaning its expression depends on the sex of the individual
Draw a genetic diagram for sex-linked inheritance
Parental phenotypes = Carrier female and Normal male
Parental genotypes = XAXa and XAY
Gametes = XA, Xa and XA, Y
Offspring genotypes = XAXA, XAXa, XAY, XaY
Offspring phenotypes = Normal female, carrier female, normal male, affected male
What is meant by multiple alleles
A gene with more than two alleles
Draw a diagram for multiple allelic inheritance
Parental phenotypes = Blood group A and Blood group B
Parental genotypes = IAIO and IBIO
Gametes = IA, IO and IB and IO
Offspring genotypes = IAIB, IAIO, IBIO, IOIO
Offspring phenotypes = Group AB, Group A, Group B, Group O
What is meant by codominant alleles
Two dominant alleles that both contribute to the phenotype either by showing a blend of both characteristics or the characteristics appearing together
Draw a genetic diagram for codominant expression
Parental Phenotypes = Red flower and white flower
Parental genotypes = cRcR and cWcW
Gametes = cR, cR and cW, cW
Offspring genotypes = cRcW
Offspring phenotypes = Pink flowers
What is meant by autsomal linkage
Where two or more genes are located on the same (non-sex) chromosome. In this case, only one homologous pair is needed for all four alleles to be present. For genes that aren’t linked, two homologous pairs are needed
What is meant by epistasis
Where two non-linked genes interact, with one gene either masking or suppressing the other gene