Pathophysiology of Pain Flashcards
A Delta fibres are ______ and transmit _____ and _____ pain
myelinated
Fat and sharp
C Fibres are ________ and _____ and transmit _______ pain
unmyelinated and slow
dull
A beta fibres are ______ and transmit __________
Myelinated
Light touch
The nociceptors initially synapse where and decussate where?
The dorsal horn
The dorsal horn (Same level it entered)
Where do the nociceptors enter to travel up towards the brain?
The spinothalamic tract
Where is the 2nd relay station in pain and where does it end ?
The thalamus
The somatosensory cortex within the brain (Posterior to the central sulcus)
What is Hyperalgesia ?
Enhanced pain response (Percieve non-noxious stimuli as noxious stimuli)
What is the main cause of Allodynia and what is it ?
The electrical threshold doesnt change but the range at which the stimuli become noxious changes.
When non-noxious stimuli become noxious
What are the 3 main components of central sensitization ?
wind-up
Classical
Long-term potentiation
What kind of medication can transduction pain issues be treated with?
NSAID’s
Ice
rest
LA Blockers
What kind of medication can transmission pain issues be treated with?
Nerve blockers
Opioids
Anticonvulsants
Surgery
What kind of medication can Perception pain issues be treated with?
Education CBT Distraction Relaxation Mirror box therapy
What kind of medication can descending modulation pain issues be treated with?
Placebos Opioids Antidepressants Surgery Spinal cord stimulation
