Pathophysiology of Heart Failure Flashcards

1
Q

What is acute?

A

Sudden onset

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2
Q

What is chronic?

A

Secondary effects

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3
Q

What is biventricular failure?

A

BOTH chambers affected

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4
Q

What would be the ejection fraction for HF?

A

<40%

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5
Q

What are the clinical features of HF?

A

Hypotension
Reduced urine flow
Cold peripheries
Breathlessness
Oedema
Atrial fibrillation
Tiredness + dizziness

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6
Q

Why is there reduced urine flow?

A

Less blood flowing round body under lower pressure

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7
Q

Why is there breathlessness?

A

NOT enough blood to the lungs

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8
Q

Why is there oedema?

A

Lungs = fluid leaking
Peripheral oedema = ankles = in common in cardiac patients

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9
Q

What are the causes of left-sided HF?

A

Impaired contractility
Pressure overload

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10
Q

What are the causes of impaired contractility?

A

Myocardial infarction
Overstretched heart
= leaky valves
= mitral/aortic regurgitation

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11
Q

What is the cause of pressure overload?

A

Uncontrolled hypertension

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12
Q

What happens in left systolic dysfunction?

A

ESV increases
EDV increases
SV decreases

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13
Q

What causes left ventricular diastolic dysfuntion?

A

LV hypertrophy = thicker walls = stiffer = doesn’t fill with blood as easily
Myocardial ischaemia = stiff ventricular wall = starved of O = difficult to refill ventricle

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14
Q

What causes obstruction of LV filling?

A

Valve disease
= narrowed mitral valve = mitral stenosis = less filling of LV
Cardiac tamponade

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15
Q

What is myocarditis?

A

Inflammatory response = effects tissue function = produces fluid = oedema = squishes the heart

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16
Q

What happens in left diastolic dysfunction?

A

EDV decreases
SV decreases

17
Q

What will vol overload result in?

A

Increase in EV, which will tigger Starling mechanism (=stretch)

18
Q

What will a positive inotrope do?

A

Increase Ca2+
= more forceful contraction

19
Q

What will ACEi do?

A

Reduce production of angiotensin II

20
Q

What will beta antagonists do?

A

Decrease degree renin-angiotensin system switched on

21
Q

What will spironolactone diuretics do?

A

Decrease fluid retention

22
Q

What will venodilators do?

A

Reduce strain on heart
= preload

23
Q

What will vasodilators do?

A

Reduce strain on heart
= afterload

24
Q

What does the renin-angiotensin system do?

A

Helps to retain fluid (Na+) = increase BP