Coated Tablets Flashcards

1
Q

What is coating (the process)?

A

Process that applies a dry outer layer of material to the surface

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2
Q

What coating (layer)?

A

Outer layer of material itself

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3
Q

What are the different types of polymer film coatings?

A

Immediate release (non-functional)
Modified release (functional)

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4
Q

What is immediate release referred as?

A

Film coating

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5
Q

What did immediate release replace?

A

Sugar coating

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6
Q

Why does immediate release not modify drug release rate?

A

Dissolves rapidly

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7
Q

Which coatings fall under modified release?

A

Enteric
Release
Gastro-resistant
Extended release

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8
Q

What is the primary role of modified release?

A

To control drug release rate

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9
Q

What are the reasons for tablet coating?

A

Improve tablet friability
Protect against oxygen, moisture and light
Improve ease of swallowing
Modify drug release profile

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10
Q

Describe immediate release of a drug

A

Rapid drug release
>75% in 45min

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11
Q

Describe delayed release of a drug

A

Gastro-resistant
Protects drug from gastric degradation
Drug release into intestines

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12
Q

Describe extended release of a drug

A

Sustained release or controlled release
Releases a larger dose over a prolonged time period

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13
Q

How do you know when it’s sustained release?
On the graph

A

Decreases to zero or down

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14
Q

How do you know when it’s controlled release?
On the graph

A

Plateaus

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15
Q

Why use extended release?

A

Keep in therapeutic range longer
Reduce amount of doses
Increase patient adherence

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16
Q

What is in film coating formulation?

A

Polymer
Plasticiser
Solvent
Colourant
Wetting agent
Anti-tack

17
Q

What is semi-synthetic polymer derived from?

18
Q

What is synthetic polymer derived from?

A

Designed + assembled artificially from monomers with different side chain chemistry

19
Q

Describe the formulation for immediate release

A

Readily dissolve in H2O
= substitute OH for R group

20
Q

Describe formulation for delayed release

A

Soluble in alkaline/ neutral = small intestines
= substitute acidic groups = dissolve in alkaline environment

21
Q

Describe formulation for extended release

A

Want to dissolve slowly
= add alkyl groups (hydrophobic) + cross links

22
Q

Describe cellulose derivatives for immediate release

A

Low molecular weight
Hydrophobic methyl substitution
Abundance of hydrophilic OH groups

23
Q

Describe cellulose derivatives for delayed release

A

Phthalate esters of cellulose derivatives
Carboxyl groups

24
Q

Describe cellulose derivatives for extended release

A

High molecular weight
May be crosslinked
Abundance of hydrophobic alkyl substituents

25
Which polymethacrylates are used for immediate release?
Aminoalkyl methacrylate copolymers
26
Which polymethacrylates are used for delayed release?
Methacrylic acid copolymers
27
Which polymethacrylates for extended release?
Aminoioalkyl methacrylate copolymers
28
What are vinyl derivatives used for?
Immediate release
29
What is the purpose of plasticiser?
Increase film flexibility, reduce brittleness
30
What are examples of plasticisers?
Polyols - propylene glycol Esters - diethyl phthalate Oils - mineral oils
31
What determines the ability of plasticisers?
Hydrogen bonding ability to bridge polymer chains
32
What are the 2 types of colourants?
Dye Pigment
33
What is a dye?
Water-soluble
34
What is a pigment?
Water-insoluble
35
What are the purpose of colourants?
Enhance visual appearance Aid product identification
36
Why are pigments preferred over dyes?
Not absorbed More photostable High opacity