Pathophysiology & clinical aspects of asthma Flashcards
1
Q
What are the 3 phases of asthma with timelines?
A
Immediate / early phase - 0 - 60 minutes after allergen exposure
Late phase - 1- 8 hours after allergen exposure
Chronic re-modelling phase - months to years
2
Q
What are the 3 key features in the pathogenesis of asthma?
A
Airway obstruction
Airway hyper-responsiveness
Airway inflammation
3
Q
Which time of day is asthma worst?
What is this due to?
A
Mornings
Cortisol decreases overnight, increasing the effects of the immune system
