Pathophysiology

Question 1

Derived from the thymus. Important in cellular immunity. Induce B cells to produce antigens

Answer 1

T cells

Question 2

a region formed by genetic loci that plays a central role in humoral & cellular immunity

Answer 2

Major histocompatibility complex (MHC)

Question 3

group of proteins that participate in antigen presentation (APC)

Answer 3

human leukocyte antigen (HLA)

Question 4

associated w/ recognition of endogenous antigens

Answer 4

Class I MHC molecules

Question 5

associated w/ recognition of exogenous antigens

Answer 5

Class II MHC molecules

Question 6

involved w/ the complement system

Answer 6

Class III MHC molecules

Question 7

Derived from bone marrow. Form plasma cells and secret immunoglobulins

Answer 7

B cells

Question 8

State of unresponsiveness specific for a particular antigen (Ag). It prevents the body from attacking itself

Answer 8

Immunological Tolerance

Question 9

Immature T cells of a clone that are not auto-reactive T cells are allowed to mature

Answer 9

positive selection

Question 10

Immature T cell clones that have high affinity for host cells are sorted out and undergo apoptosis

Answer 10

negative selection

Question 11

State of immunologic tolerance to Ag

Answer 11

anergy

Question 12

Immunologic cells are involved in tissue injury that results in exposure of self-antigen.

Answer 12

autoimmune disorders

Question 13

Two diseases that result from a protein in the cell wall of group A Beta hemolytic streptococci that has considerable similarity to Ag in heart and kidney

Answer 13

Rheumatic Fever and Acute Glomerulonephritis

Question 14

What hormone is thought to play a role in autoimmune disorders due to the greater prevalence of these conditions in women?

Answer 14

estrogen

Question 15

Term for phenomen of a foreign Ag that so closely resembles a self Ag that Ab produced against the foreign antigen attack the self antigen

Answer 15

molecular mimicry

Question 16

Pathogenesis of this immune disorder is caused by autoantibodies that stimulate platelet derived growth factor receptors (PSGFR) causing fibroblast dysregulation

Answer 16

scleroderma

Question 17

Pathogenesis of this immune disorder is caused by RF and IgG form immune complexes that fix complement, attract neutrophils and lead to tissue injury

Answer 17

rheumatoid arthritis

Question 18

Pathogenesis of this immune disorder is caused by effects are secondary to trapping Ag-Ab complexes in capillaries of visceral structures

Answer 18

SLE