Lupus Flashcards
Deposition of antigen-antibody complexes along vascular and tissue basement membranes.
SLE
What is the ratio of the incidence of lupus in women compared to men?
9:1 (more common in women btw 20-40)
Chromosome most often involved with lupus
chromosome 6
What cells of the immune system are involved with the hyperactivity reaction of lupus?
B-lymphocytes
What type of autoimmune reaction is lupus characterized as?
type III (caused by antibody-immune complex formation)
Common initial presenting symptoms of lupus
butterfly rash, discoid lesions, photosensitivity, and oral/genital/nasal ulcers
What is the difference between the polyarthritis of RA and Lupus?
In lupus polyarthritis is symmetrical, but unlike RA does not involve articular destruction
Renal features associated with SLE
glomerulonephritis, nephrotic syndrome, and HTN
Feature of lupus that presents with nonproductive cought, dyspnea, hypoxemia
Transient basilar pneumonic infiltrates (“lupus pneumonitis”)
Cardiac feature of SLE characterized by tachycardia, ventricular arrhythmia, conduction problems, CHF/cardiomyopathy
myocarditis
Surface vegetations on valves due to aggregation of platelets
Libman-Sacks endocarditis
Palpable purpuric lesion on the shins in a patient with lupus and necrotizing vasculitis of the skin, kidney, brain
lupus vasculitis
Manifested by reddish-cyanotic, reticular pattern of the skin that results in ulcer formation
livedo reticularis
Increased GI tract condition with SLE
primary biliary cirrhosis
Most common cause of death in early active SLE
Infectious complications related to active SLE and immunosuppressive treatment
What causes the prolonged PTT of SLE?
antiphospholipid antibodies
Primarily musculoskeletal, pulmonary, and polyserositic symptoms. No hypocomplementemia. Anti-nuclear antibodies present, but return to normal with withdrawal of drug
Drug Induced Lupus Syndromes
Most common culprits for drug induced lupus syndromes
Procainamide and hydralazine
Chronic cutaneous lupus
Involves plaque-like lesions of head, scalp and neck. First appear as red, swollen patches or skin. Later scarring, depigmentation, plugging of hair follicles.
discoid lupus
