Pathophysiology Flashcards
1
Q
Factors that worsen insulin resistance
A
Factors that influence insulin resistance
• Obesity
• Genetics
•Age
•Ketones
•Pregnancy
• Glucose toxicity
•Uremia
• Cancer
2
Q
Causes of CKD in people with diabetes
A
- diabetic nephropathy
- ischemic nephropathy related to vascular disease
- hypertensive nephro-sclerosis
- other renal diseases that are unrelated to diabetes
3
Q
Glucose threshold at which the body makes insulin
A
BG > 3.9mmol/L
4
Q
Things that add to insulin resistance
A
Obesity
T2DM
Hyperglycaemia (so people with t1dm can also struggle with insulin resistance)
Adolescence
Pregnancy
5
Q
How many grams of glucose does the kidneys filter in a day (in a healthy person)?
A
180g
When plasma glucose is >10mmol/L (renal threshold), extra glucose is excreted into urine
Chronic hyperglycaemia can increase the renal threshold