Pathophysiology Flashcards

1
Q

Factors that worsen insulin resistance

A

Factors that influence insulin resistance
• Obesity
• Genetics
•Age
•Ketones
•Pregnancy
• Glucose toxicity
•Uremia
• Cancer

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2
Q

Causes of CKD in people with diabetes

A
  • diabetic nephropathy
  • ischemic nephropathy related to vascular disease
  • hypertensive nephro-sclerosis
  • other renal diseases that are unrelated to diabetes
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3
Q

Glucose threshold at which the body makes insulin

A

BG > 3.9mmol/L

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4
Q

Things that add to insulin resistance

A

Obesity
T2DM
Hyperglycaemia (so people with t1dm can also struggle with insulin resistance)
Adolescence
Pregnancy

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5
Q

How many grams of glucose does the kidneys filter in a day (in a healthy person)?

A

180g
When plasma glucose is >10mmol/L (renal threshold), extra glucose is excreted into urine
Chronic hyperglycaemia can increase the renal threshold

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