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1 STEP UWorld neuro+psycho > Pathoma CNS tumors 01-21 > Flashcards

Pathoma CNS tumors 01-21 Flashcards

1
Q

Glioblastoma mutiforme? M, B?

A

Malignant

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2
Q

Meningioma? M, B?

A

Benign

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3
Q

Schwannoma? M, B?

A

Benign

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4
Q

Oligodendroglioma? M, B?

A

Malignant

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5
Q

Pilocytic astrocytoma? M, B?

A

Benign

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6
Q

Medulloblastoma? M, B?

A

Malignant

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7
Q

Ependymoma? M, B?

A

Malignant

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8
Q

Craniopharyngioma? M, B?

A

Benign

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9
Q

What proc. primary and what metastatic?

A

50/50

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10
Q

Metastatic - what characteristic?

A

Multiple, well-circumscribed lesions at the gray-white junction

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11
Q

Multiple, well-circumscribed lesions at the gray-white junction?

A

Metastatic

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12
Q

What are common sources for metastatic tumors?

A

from lungs (#1), breast and kidneys

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13
Q

Primary tumors. How classified?

A

Classified according to cells type of origin.

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14
Q

Primary in adults - where usually?

A

SUPRAtentorial (cerebrum)

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15
Q

What are 3 most common tumors in adults?

A

GBM (M), meningioma (B), schwannoma (B)

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16
Q

Primary in children - where most commonly?

A

INFRAtentorial (cerebellum)

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17
Q

SUPRAtentorial (cerebrum)?

A

In adults

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18
Q

INFRAtentorial (cerebellum)?

A

In children

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19
Q

Tentorium - riba tarp smegenu ir smegeneliu

A

.

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20
Q

what are the most common tumors in children?

A

Pilocytic astrocytoma (B), ependymoma (M), Medulloblastoma (M)

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21
Q

Characteristic for primary malignant tumors?

A

Locally destructive, but rarely metastasize

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22
Q

GBM. (malignant, in adults). What cells?

A

High grade tumor of ASTROCYTES

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23
Q

High grade turmor of ASTROCYTES

A

GBM. (malignant, in adults).

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24
Q

What is the most common primary CNS tumor in adults?

A

GBM. (malignant, in adults)

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25
Q

GBM. (malignant, in adults). Where usually arises? What is characteristic feature?

A

In the cerebral hemisphere.
Characteristically crosses the corpus callosum ,,butterfly lesion”.

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26
Q

butterfly lesion?

A

GBM. (malignant, in adults)

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27
Q

GBM. (malignant, in adults). Prognosis?

A

Poor

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28
Q

GBM. (malignant, in adults). positive for what?

A

GFAP (neuroglia).

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29
Q

GBM. (malignant, in adults). Histology?

A

Regions of necrosis surrounded by tumor cells (pseudopalisading) and ENDOTHELIAL cell proliferation

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30
Q

GFAP positive? 2 tumors (adult and children)

A

GBM. (malignant, in adults).
Pylocytic astrocytoma (B, children).

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31
Q

Regions of necrosis surrounded by tumor cells (pseudopalisading) and ENDOTHELIAL cell proliferation?

A

GBM. (malignant, in adults).

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32
Q

WHat is the most common BENIGN tumor in adults?

A

Meningioma (B, adults).

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33
Q

Meningioma (B, adults). In what population?

A

More common in women. rare in children.

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34
Q

Meningioma (B, adults). May be what symptoms?

A

Seizures.
Tumor compresses, but does not invade, the cortex

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35
Q

Seizures.
Tumor compresses, but does not invade, the cortex?

A

Meningioma (B, adults).

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36
Q

Meningioma (B, adults). What shows imaging?

A

round mass attached to the dura

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37
Q

round mass attached to the dura?

A

Meningioma (B, adults).

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38
Q

Meningioma (B, adults). Histology?

A

Whorled pattern ,,susuktas rastas”; psamossa bodies may be present

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39
Q

Whorled pattern ,,susuktas rastas”; psamossa bodies may be present?

A

Meningioma (B, adults).

40
Q

Meningioma (B, adults). What cells?

A

Arachnoid

41
Q

Schwannoma (B, adults). What cells?

A

Schwann cells

42
Q

Schwannoma (B, adults). Involves what parts?

A

Cranial and spinal nerves.

43
Q

Schwannoma (B, adults). In cranium what nerves involve?

A

Cranial nerve VIII at the cerebellopontine angle (AKA VESTIBULAR SCHWANNOMA) -> presents as hearing loss and tinnitus

44
Q

Cranial nerve VIII at the cerebellopontine angle (AKA VESTIBULAR SCHWANNOMA) -> presents as hearing loss and tinnitus?

A

Schwannoma (B, adults).

45
Q

Schwannoma (B, adults). positive for what?

A

S-100

46
Q

S100 positive?

A

Schwannoma (B, adults).

47
Q

Schwannoma (B, adults). in what disease are seen bilateral tumors?

A

Neurofibromatosis type 2

48
Q

Neurofibromatosis type 2?

A

Schwannoma (B, adults).

49
Q

Pylocytic astrocytoma (B, children). what cells?

A

benign tumor of astrocytes

50
Q

What is the most common CNS tumor in children?

A

Pylocytic astrocytoma (B, children).

51
Q

Pylocytic astrocytoma (B, children). where usually arises?

A

in the cerebellum

52
Q

Pylocytic astrocytoma (B, children). Imaging?

A

Cystic lesion with a mural nodule

53
Q

Imaging:Cystic lesion with a mural nodule?

A

Pylocytic astrocytoma (B, children).

54
Q

Pylocytic astrocytoma (B, children). In which anatomical site?

A

Posterior fossa, infrantentorium.

55
Q

Pylocytic astrocytoma (B, children). Biopsy?

A

Rosenthal fibers (thick eosinophilic processes of astrocytes) and eosinophilic granular bodies

56
Q

Pylocytic astrocytoma (B, children). positive for what?

A

GFAP

57
Q

Pylocytic astrocytoma (B, children). Prognosis?

A

good

58
Q

Rosenthal fibers (thick eosinophilic processes of astrocytes) and eosinophilic granular bodies?

A

Pilocytic astrocytoma (B, children).

59
Q

what is Rosenthal fibers?

A

thick eosinophilic processes of astrocytes.
In Pilocytic astrocytoma (B, children).

60
Q

Ependymoma (M, children). cells?

A

Ependymal cells

61
Q

Ependymal cells?

A

Ependymoma (M, children).

62
Q

Ependymoma (M, children). Where usually arises?

A

in 4th ventricle

63
Q

arises in 4th ventricle?

A

Ependymoma (M, children).

64
Q

Ependymoma (M, children). may present with what neuro symptom?

A

hydrocephalus

65
Q

May present as hydrocephalus in what?

A

Ependymoma (M, children).

66
Q

Ependymoma (M, children). histology?

A

Perivascular pseudorosettes

67
Q

Perivascular pseudorosettes?

A

Ependymoma (M, children).

68
Q

Medulloblastoma (M, children). cells?

A

granular cells of the cerebellum (neuroectoderm)

69
Q

granular cells of the cerebellum (neuroectoderm)?

A

Medulloblastoma (M, children).

70
Q

Medulloblastoma (M, children). Histology?

A

Small, round blue cells; Homer-Wright rosettes may be present.

71
Q

Small, round blue cells; Homer-Wright rosettes may be present?

A

Medulloblastoma (M, children).

72
Q

Medulloblastoma (M, children). Prognosis?

A

poor

73
Q

Medulloblastoma (M, children). spreads where?

A

Grows rapidly and spreads via CSF

74
Q

Grows rapidly and spreads via CSF?

A

Medulloblastoma (M, children).

75
Q

Medulloblastoma (M, children). what metastasis?

A

Metastasis to the caude equina is termed as ,drop metastasis’.

76
Q

Metastasis to the caude equina is termed as ,drop metastasis’?

A

Medulloblastoma (M, children).

77
Q

Oligodendroglioma (M). cells?

A

oligodendrocytes

78
Q

oligodendrocytes?

A

Oligodendroglioma (M).

79
Q

Oligodendroglioma (M). Imaging?

A

Calcified tumor in the white matter.

80
Q

Imaging: Calcified tumor in the white matter.

A

Oligodendroglioma (M).

81
Q

Oligodendroglioma (M). usually involves what?

A

frontal lobe

82
Q

Involves frontal lobe?

A

Oligodendroglioma (M).

83
Q

Oligodendroglioma (M). what symptoms?

A

seizures

84
Q

Oligodendroglioma (M). Biopsy?

A

egg-fried appearance of cells

85
Q

egg-fried appearance of cells

A

Oligodendroglioma (M).

86
Q

Frontal involvement and seizures?

A

Oligodendroglioma (M).

87
Q

Craniopharyngioma (B, children/adult). cells?

A

Epithelial remnants of Rathke’s pouch

88
Q

Epithelial remnants of Rathke’s pouch?

A

Craniopharyngioma (B, children/adult).

89
Q

Craniopharyngioma (B, children/adult). where mass?

A

Supratentorial

90
Q

Craniopharyngioma (B, children/adult). may compress what and what symptom?

A

compress optic chiasm leading to bitemporal hemianopsia.

91
Q

compress optic chiasm leading to bitemporal hemianopsia?

A

Craniopharyngioma (B, children/adult).

92
Q

Craniopharyngioma (B, children/adult). What is common finding in imaging?

A

Calcifications (derived from tooth-like tissue”

93
Q

Imaging: Calcifications (derived from ,,tooth-like tissue”)

A

Craniopharyngioma (B, children/adult).

94
Q

what tumors tends to reoccur after resection?

A

Craniopharyngioma (B, children/adult).

95
Q

Meduloblastoma is a form of ……

A

primitive neuroectodermal tumor

1 STEP UWorld neuro+psycho (10 decks)

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