Pathoma CNS tumors 01-21 Flashcards
1
Q
Glioblastoma mutiforme? M, B?
A
Malignant
2
Q
Meningioma? M, B?
A
Benign
3
Q
Schwannoma? M, B?
A
Benign
4
Q
Oligodendroglioma? M, B?
A
Malignant
5
Q
Pilocytic astrocytoma? M, B?
A
Benign
6
Q
Medulloblastoma? M, B?
A
Malignant
7
Q
Ependymoma? M, B?
A
Malignant
8
Q
Craniopharyngioma? M, B?
A
Benign
9
Q
What proc. primary and what metastatic?
A
50/50
10
Q
Metastatic - what characteristic?
A
Multiple, well-circumscribed lesions at the gray-white junction
11
Q
Multiple, well-circumscribed lesions at the gray-white junction?
A
Metastatic
12
Q
What are common sources for metastatic tumors?
A
from lungs (#1), breast and kidneys
13
Q
Primary tumors. How classified?
A
Classified according to cells type of origin.
14
Q
Primary in adults - where usually?
A
SUPRAtentorial (cerebrum)
15
Q
What are 3 most common tumors in adults?
A
GBM (M), meningioma (B), schwannoma (B)
16
Q
Primary in children - where most commonly?
A
INFRAtentorial (cerebellum)
17
Q
SUPRAtentorial (cerebrum)?
A
In adults
18
Q
INFRAtentorial (cerebellum)?
A
In children
19
Q
Tentorium - riba tarp smegenu ir smegeneliu
A
.
20
Q
what are the most common tumors in children?
A
Pilocytic astrocytoma (B), ependymoma (M), Medulloblastoma (M)
21
Q
Characteristic for primary malignant tumors?
A
Locally destructive, but rarely metastasize
22
Q
GBM. (malignant, in adults). What cells?
A
High grade tumor of ASTROCYTES
23
Q
High grade turmor of ASTROCYTES
A
GBM. (malignant, in adults).
24
Q
What is the most common primary CNS tumor in adults?
A
GBM. (malignant, in adults)
25
GBM. (malignant, in adults). Where usually arises? What is characteristic feature?
In the cerebral hemisphere.
Characteristically crosses the corpus callosum ,,butterfly lesion".
26
butterfly lesion?
GBM. (malignant, in adults)
27
GBM. (malignant, in adults). Prognosis?
Poor
28
GBM. (malignant, in adults). positive for what?
GFAP (neuroglia).
29
GBM. (malignant, in adults). Histology?
Regions of necrosis surrounded by tumor cells (pseudopalisading) and ENDOTHELIAL cell proliferation
30
GFAP positive? 2 tumors (adult and children)
GBM. (malignant, in adults).
Pylocytic astrocytoma (B, children).
31
Regions of necrosis surrounded by tumor cells (pseudopalisading) and ENDOTHELIAL cell proliferation?
GBM. (malignant, in adults).
32
WHat is the most common BENIGN tumor in adults?
Meningioma (B, adults).
33
Meningioma (B, adults). In what population?
More common in women. rare in children.
34
Meningioma (B, adults). May be what symptoms?
Seizures.
Tumor compresses, but does not invade, the cortex
35
Seizures.
Tumor compresses, but does not invade, the cortex?
Meningioma (B, adults).
36
Meningioma (B, adults). What shows imaging?
round mass attached to the dura
37
round mass attached to the dura?
Meningioma (B, adults).
38
Meningioma (B, adults). Histology?
Whorled pattern ,,susuktas rastas"; psamossa bodies may be present
39
Whorled pattern ,,susuktas rastas"; psamossa bodies may be present?
Meningioma (B, adults).
40
Meningioma (B, adults). What cells?
Arachnoid
41
Schwannoma (B, adults). What cells?
Schwann cells
42
Schwannoma (B, adults). Involves what parts?
Cranial and spinal nerves.
43
Schwannoma (B, adults). In cranium what nerves involve?
Cranial nerve VIII at the cerebellopontine angle (AKA VESTIBULAR SCHWANNOMA) -> presents as hearing loss and tinnitus
44
Cranial nerve VIII at the cerebellopontine angle (AKA VESTIBULAR SCHWANNOMA) -> presents as hearing loss and tinnitus?
Schwannoma (B, adults).
45
Schwannoma (B, adults). positive for what?
S-100
46
S100 positive?
Schwannoma (B, adults).
47
Schwannoma (B, adults). in what disease are seen bilateral tumors?
Neurofibromatosis type 2
48
Neurofibromatosis type 2?
Schwannoma (B, adults).
49
Pylocytic astrocytoma (B, children). what cells?
benign tumor of astrocytes
50
What is the most common CNS tumor in children?
Pylocytic astrocytoma (B, children).
51
Pylocytic astrocytoma (B, children). where usually arises?
in the cerebellum
52
Pylocytic astrocytoma (B, children). Imaging?
Cystic lesion with a mural nodule
53
Imaging:Cystic lesion with a mural nodule?
Pylocytic astrocytoma (B, children).
54
Pylocytic astrocytoma (B, children). In which anatomical site?
Posterior fossa, infrantentorium.
55
Pylocytic astrocytoma (B, children). Biopsy?
Rosenthal fibers (thick eosinophilic processes of astrocytes) and eosinophilic granular bodies
56
Pylocytic astrocytoma (B, children). positive for what?
GFAP
57
Pylocytic astrocytoma (B, children). Prognosis?
good
58
Rosenthal fibers (thick eosinophilic processes of astrocytes) and eosinophilic granular bodies?
Pilocytic astrocytoma (B, children).
59
what is Rosenthal fibers?
thick eosinophilic processes of astrocytes.
In Pilocytic astrocytoma (B, children).
60
Ependymoma (M, children). cells?
Ependymal cells
61
Ependymal cells?
Ependymoma (M, children).
62
Ependymoma (M, children). Where usually arises?
in 4th ventricle
63
arises in 4th ventricle?
Ependymoma (M, children).
64
Ependymoma (M, children). may present with what neuro symptom?
hydrocephalus
65
May present as hydrocephalus in what?
Ependymoma (M, children).
66
Ependymoma (M, children). histology?
Perivascular pseudorosettes
67
Perivascular pseudorosettes?
Ependymoma (M, children).
68
Medulloblastoma (M, children). cells?
granular cells of the cerebellum (neuroectoderm)
69
granular cells of the cerebellum (neuroectoderm)?
Medulloblastoma (M, children).
70
Medulloblastoma (M, children). Histology?
Small, round blue cells; Homer-Wright rosettes may be present.
71
Small, round blue cells; Homer-Wright rosettes may be present?
Medulloblastoma (M, children).
72
Medulloblastoma (M, children). Prognosis?
poor
73
Medulloblastoma (M, children). spreads where?
Grows rapidly and spreads via CSF
74
Grows rapidly and spreads via CSF?
Medulloblastoma (M, children).
75
Medulloblastoma (M, children). what metastasis?
Metastasis to the caude equina is termed as ,drop metastasis'.
76
Metastasis to the caude equina is termed as ,drop metastasis'?
Medulloblastoma (M, children).
77
Oligodendroglioma (M). cells?
oligodendrocytes
78
oligodendrocytes?
Oligodendroglioma (M).
79
Oligodendroglioma (M). Imaging?
Calcified tumor in the white matter.
80
Imaging: Calcified tumor in the white matter.
Oligodendroglioma (M).
81
Oligodendroglioma (M). usually involves what?
frontal lobe
82
Involves frontal lobe?
Oligodendroglioma (M).
83
Oligodendroglioma (M). what symptoms?
seizures
84
Oligodendroglioma (M). Biopsy?
egg-fried appearance of cells
85
egg-fried appearance of cells
Oligodendroglioma (M).
86
Frontal involvement and seizures?
Oligodendroglioma (M).
87
Craniopharyngioma (B, children/adult). cells?
Epithelial remnants of Rathke's pouch
88
Epithelial remnants of Rathke's pouch?
Craniopharyngioma (B, children/adult).
89
Craniopharyngioma (B, children/adult). where mass?
Supratentorial
90
Craniopharyngioma (B, children/adult). may compress what and what symptom?
compress optic chiasm leading to bitemporal hemianopsia.
91
compress optic chiasm leading to bitemporal hemianopsia?
Craniopharyngioma (B, children/adult).
92
Craniopharyngioma (B, children/adult). What is common finding in imaging?
Calcifications (derived from tooth-like tissue"
93
Imaging: Calcifications (derived from ,,tooth-like tissue")
Craniopharyngioma (B, children/adult).
94
what tumors tends to reoccur after resection?
Craniopharyngioma (B, children/adult).
95
Meduloblastoma is a form of ......
primitive neuroectodermal tumor
