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1 STEP UWorld neuro+psycho > Epilepsy drugs > Flashcards

Epilepsy drugs Flashcards

1
Q

For what epilepsy: BZD?

A

Status epilepticus first-line

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2
Q

For what epilepsy: Carbamazepine?

A

Partial (common use); Tonic-clonic

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3
Q

For what epilepsy: Ethosuximide?

A

Absent seizures first line

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4
Q

For what epilepsy: gabapentin?

A

Partial (focal)

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5
Q

For what epilepsy: Lamotrigine?

A

Partial (focal), tonic-clonic, absence

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6
Q

For what epilepsy: Levetiracetam?

A

Partial (focal), tonic-clonic.
Status epilepticus (duodi BZD ir tada sita, kad nesikartotu)

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7
Q

For what epilepsy: Phenobarbital?

A

Partial (focal), tonic-clonic. Status epilepticus

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8
Q

For what epilepsy: phenytoin, fosphenytoin?

A

Partial (focal), tonic-clonic (common use). Status epilepticus - 1st line for recurrent seizures prophylaxis

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9
Q

For what epilepsy: topiramate?

A

Partial (focal), tonic-clonic

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10
Q

For what epilepsy: Valproic acid?

A

Partial (focal), tonic-clonic (common use), absence, status epilepticus (irgi ten kazkelintas eilej po BZD)

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11
Q

For what epilepsy: vigabatrin?

A

partiqal (focal)

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12
Q

BZD mechanism?

A

Incr. GABA A action (incr frequency of Cl- channel opening)

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13
Q

Carbamazepine mechanism?

A

Blocks Na channels

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14
Q

Ethosuximide mechanism?

A

Blocks T-type Ca channels in thalamic

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15
Q

Gabapentin mechanism?

A

Primarily inhibits high-voltage-activated-Ca channels.
Designed as GABA analog

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16
Q

Lamotrigine mechanism?

A

Blocks voltage-gated Na channels,
inhibits the release of glutamate

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17
Q

Levetiracetam mechanism?

A

unknown.
May modulate GABA and Glutamate release, inhibit voltage-gated Ca channels

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18
Q

Phenobarbital mechanism?

A

Incr. GABA A action

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19
Q

Phenytoin, fosphenytoin mechanism?

A

Blocks Na channels. zero-order kinetics

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20
Q

Topiramate mechanism?

A

Blocks Na channels, incr GABA action

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21
Q

Valproic acid mechanism?

A

Inc. Na channel inactivation, Incr. GABA concentration by inhibiting GABA transaminase

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22
Q

Vigabatrin mechanism?

A

Incr. GABA. Irreversible GABA transaminase inhibitor

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23
Q

Permanent visual loss (black box warning)?

A

Vigabatrin

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24
Q

Stevens Johnson Syndrome?

A

Lamotrigine, phenytoin, fosphenytoin, carbamazepine, ethosuximide

25
Q

Induction of P-450?

A

Phenobarbital, phenytoin, fosphenytoin, carbamazepine

26
Q

Sedation, tolerance, dependence, resp. depression?

A

BZD

27
Q

Seizures in eclampsia?

A

BZD (bet MgSO4 vis tiek first line)

28
Q

First line for trigeminal neuralgia?

A

Carbamazepine

29
Q

teratogenic?

A

Carbamazepine, Phenytoin, fosphenytoin, vaproic acid

30
Q

carbamazepine teratogenicity?

A

cleft lip/palate, spina bifida

31
Q

Phenytoin, fosphenytoin teratogenicity?

A

fetal hydantoin syndrome

32
Q

SIADH?

A

Carbamazepine

33
Q

used for pheripheral neuropthy, postherpetic neuralgia?

A

Gabapentin

34
Q

Sedation, ataxia?

A

Gabapentin

35
Q

First line in neonates?

A

Phenobabital

36
Q

which one cardiorespiratory depression and what only respiratory even less?

A

Cardioresp - barbiturates
resp - BZD
With BZD less risk for resp. depression

37
Q

Migraine prophylaxis?

A

Topiramate

38
Q

Myoclonic seizures, bipolar disorder, migraine prophylaxis?

A

Valproic acid

39
Q

Neuropsychiatric symptoms (eg personality change), fatigue, drowsiness, headache?

A

Levetiracetam

40
Q

Hemophagocytic lymphohistiocytosis (blac box warning)?

A

Lamotrigine

41
Q

Sedation, tolerance, dependence, induction of P450, cardioresp. depression?

A

Phenobarbital

42
Q

Fatigue, GI distress, headache, ithchin (and urticaria) SJS?

A

Ethosuximide

43
Q

Blood dyscrasias (agranulocytosis, aplastic anemia)?

A

Carbamazepine

44
Q

Diplopia, ataxia, Blood dyscrasias (agranulocytosis, aplastic anemia), P450, SJS, teratogenic, SIADH

A

Carbamazepine

45
Q

Weight loss?

A

topiramate

46
Q

weight gain?

A

valproic acid

47
Q

sedation, slow cognition, kidney stones, weight loss, glaucoma, word-finding difficulties?

A

topiramate

48
Q

Gi distress, rare but fatal hepatotoxicity (measure LFT), pancreatitis, neutral tube defects, tremor, weight gain?

A

valproic acid

49
Q

hirsuitism?

A

Phenytoin, fosphenytoin

50
Q

Gingival hyperplasia?

A

Phenytoin, fosphenytoin

51
Q

Nystagmus?

A

Phenytoin, fosphenytoin

52
Q

Yellow-brown skin?

A

Phenytoin, fosphenytoin

53
Q

Osteopenia?

A

Phenytoin, fosphenytoin

54
Q

Inhibited folate absorbtion?

A

Phenytoin, fosphenytoin

55
Q

neuropathy?

A

Phenytoin, fosphenytoin

56
Q

DRESS syndrome?

A

Phenytoin, fosphenytoin

57
Q

SLE-like syndrome?

A

Phenytoin, fosphenytoin

58
Q

Toxicity leads to diplopia, ataxia, sedation?

A

Phenytoin, fosphenytoin

1 STEP UWorld neuro+psycho (10 decks)

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