BZD and barbiturates drugs Flashcards
Barbituratai?4
Phenobarbital;
Pentobarbital;
Thiopental;
Secobarbital
Barbituratai:
…………..
Pentobarbital;
Thiopental;
Secobarbital
Phenobarbital;
Barbituratai:
Phenobarbital;
…….
Thiopental;
Secobarbital
Pentobarbital;
Barbituratai:
Phenobarbital;
Pentobarbital;
…….
Secobarbital
Thiopental;
Barbituratai:
Phenobarbital;
Pentobarbital;
Thiopental;
…….
Secobarbital
barbiturates act on what receptors?
GABA A
barbiturates - what happens on GABA?
Facilitated GABA A action by INCREASING DURATION of Cl- channel opening –> thus decr. neuronal firing
Facilitated GABA A action by INCREASING DURATION of Cl- channel opening –> thus decr. neuronal firing.
What drugs?
Barbiturates
use of barbiturates?
anxiety, seizures, insomnia, induction of anesthesia (thiopental)
which barbiturate is used for induction of anesthesia?
thiopental
Adverse of babiturates - fatal?
respiratory and cardiovascular depression.
In overdose - supportive treatment, such assist respirations and maintain BP.
Why dont use barbiturates with alcohol?
CNS depression
barbiturates - dependence, sedation, tolerance
.
Barbiturates - drug interaction?
Induces P-450
Barbiturates contraindicated in what?
porphyria
For what seizures is used phenobarbital?
partial (focal); tonic-clonic; status epilepticus
Short acting BZD?
ATOM: Alprazolam (xanax), oxazepam, midazolam, triazolam
Medium acting BZD?
Lorazepam, temazepam, clonazepam
Long-lasting BZD?
Diazepam, Chlordiazepoxide
BZD act on what receptors?
GABA A
What is action of BZD on GABA A?
Facilitate GABA A action by INCREASING FREQUENCY of Cl- channel opening, decr. REM sleep.
Facilitate GABA A action by INCREASING FREQUENCY of Cl- channel opening, decr. REM sleep.
What drugs?
BZD
what BZD have highest risk for addiction?
short acting - ATOM: alprazolam, triazolam, oxazepam, midazolam
What BZD used in liver disease?
LOT - Lorazepam, oxazepam, temazepam
due to minimal first-pass metabolism
