BZD and barbiturates drugs

Question 1

Barbituratai?4

Answer 1

Phenobarbital;
Pentobarbital;
Thiopental;
Secobarbital

Question 2

Barbituratai:
…………..
Pentobarbital;
Thiopental;
Secobarbital

Answer 2

Phenobarbital;

Question 3

Barbituratai:
Phenobarbital;
…….
Thiopental;
Secobarbital

Answer 3

Pentobarbital;

Question 4

Barbituratai:
Phenobarbital;
Pentobarbital;
…….
Secobarbital

Answer 4

Thiopental;

Question 5

Barbituratai:
Phenobarbital;
Pentobarbital;
Thiopental;
…….

Answer 5

Secobarbital

Question 6

barbiturates act on what receptors?

Answer 6

GABA A

Question 7

barbiturates - what happens on GABA?

Answer 7

Facilitated GABA A action by INCREASING DURATION of Cl- channel opening –> thus decr. neuronal firing

Question 8

Facilitated GABA A action by INCREASING DURATION of Cl- channel opening –> thus decr. neuronal firing.

What drugs?

Answer 8

Barbiturates

Question 9

use of barbiturates?

Answer 9

anxiety, seizures, insomnia, induction of anesthesia (thiopental)

Question 10

which barbiturate is used for induction of anesthesia?

Answer 10

thiopental

Question 11

Adverse of babiturates - fatal?

Answer 11

respiratory and cardiovascular depression.
In overdose - supportive treatment, such assist respirations and maintain BP.

Question 12

Why dont use barbiturates with alcohol?

Answer 12

CNS depression

Question 13

barbiturates - dependence, sedation, tolerance

Answer 13

.

Question 14

Barbiturates - drug interaction?

Answer 14

Induces P-450

Question 15

Barbiturates contraindicated in what?

Answer 15

porphyria

Question 16

For what seizures is used phenobarbital?

Answer 16

partial (focal); tonic-clonic; status epilepticus

Question 17

Short acting BZD?

Answer 17

ATOM: Alprazolam (xanax), oxazepam, midazolam, triazolam

Question 18

Medium acting BZD?

Answer 18

Lorazepam, temazepam, clonazepam

Question 19

Long-lasting BZD?

Answer 19

Diazepam, Chlordiazepoxide

Question 20

BZD act on what receptors?

Answer 20

GABA A

Question 21

What is action of BZD on GABA A?

Answer 21

Facilitate GABA A action by INCREASING FREQUENCY of Cl- channel opening, decr. REM sleep.

Question 22

Facilitate GABA A action by INCREASING FREQUENCY of Cl- channel opening, decr. REM sleep.

What drugs?

Answer 22

BZD

Question 23

what BZD have highest risk for addiction?

Answer 23

short acting - ATOM: alprazolam, triazolam, oxazepam, midazolam

Question 24

What BZD used in liver disease?

Answer 24

LOT - Lorazepam, oxazepam, temazepam
due to minimal first-pass metabolism

Question 25

Indications for BZD?

Answer 25

Anxiety, panic disorder, spasticity, status epilepticus (LDM), eclampsia, detoxification (esp. alcohol withdrawal), night terrors, sleepwalking, general anesthetic, hypnotic (insomnia).

Question 26

BZD adverse?

Answer 26

Dependence, CNS depression with alcohol and barbiturates.

Question 27

What - barbiturates or BZD- have higher risk for respiratory depression and coma?

Answer 27

Barbiturates have higher risk, BZD - lower risk

Question 28

BZD overdose treatment?

Answer 28

flumazenil (competitive antagonist at GABA BZD receptor)

Question 29

BZD dont use with what?

Answer 29

Barbiturates, alcohol, 1st antihistamines (cross BBB –> sedation), neuroleptics.