Pathology Picture Cards Flashcards
What is this?
Leiomyoma
What is this? What are those things at the tips of the arrows?
Leiomyosarcoma. Areas of necrosis are at the tips of the arrows.
Is this a benign, or malignant tumor? Why?
Benign. It is well circumscribed, cells in the tumor look a lot like the cell of origin.
What kind of tumor is this?
Teratoma
What type of tumor is this? Is it benign, or malignant?
Meningioma, benign (but still dangerous due to mass effect!)
What type of epithelium does this look like? Is it neoplastic?
It is urothelium/transitional epithelium - in situ neoplasia. Urothelial cells look like umbrellas - to keep you from getting urinated on!
Which side is normal, and which side is neoplastic (in-situ)?
Right side is in-situ neoplasia (cervical)
Benign or neoplastic? In-situ or malignant?
In-situ neoplasia
Benign or neoplastic? In-situ or malignant?
In-situ neoplasia
What is your diagnosis?
Invasive ductal carcinoma
Benign or neoplastic? In-situ or malignant?
Normal colonic mucosa
Benign or neoplastic? In-situ or malignant?
In-situ neoplasia of the colon
Benign or neoplastic? In-situ or malignant?
Invasive carcinoma of the colon
Benign or neoplastic? In-situ or malignant?
Normal endometrium
What is your diagnosis?
Squamous cell carcinoma. Whorls of keratin are diagnostic for this (see photo)
What is your diagnosis?
Colonic adenocarcinoma
This is from a biopsy of the uterus. What is your diagnosis?
Leiomyosarcoma. Cells are not differentiated and pleiomorphic. See photo for how smooth muscle should look.
What is your diagnosis?
Adenocarcinoma - it is trying to form glands
What is your diagnosis?
Melanoma - note the melanin pigments
What is your diagnosis?
osteosarcoma
What is your diagnosis?
Liposarcoma
What is your diagnosis?
Lymphoma
One of these is a high-grade breast ductal carcinoma, and one is a low-grade. Which one is which?
Low grade is on the left, high grade is on the right.
The slide on the left is from the same organ as the “normal” slide on the right. What is your diagnosis?
Low-grade papillary thyroid carcinoma
What is up with this liver?
Cirrhosis
This is from a liver biopsy. What is your diagnosis and why?
Cirrhosis. Trichrome stain shows lots of collagen fibers (blue) in between nodules of hepatocytes, which is characteristic of liver cirrhosis.
This slide is from a liver biopsy. What are those inclusions? Name a disease in which you would find this.
Iron accumulation in a patient with hereditary hemochromatosis
What is up with this pancreas?
Iron accumulation - hereditary hemochromatosis
This is from a liver. What are the red spots? What stain was used?
Red spots are fat. Oil red O stain
This slide is from the CNS. What is your diagnosis?
Gaucher’s disease - accumulation of glucocerebroside
Name the cell types (1 and 2). What is the structure labeled #3? What is the stuff surrounding #3?
- Normal neuron
- Glial cells
- Blood vessel
- Vessel wall full of amyloid - can cause a stroke!
Identify the tissue. What are the things marked by arrows?
Cardiac muscle. Lipofuscin
This is brain tissue. What stain is used and what is it staining?
Congo red birefringence “Apple Green” stains amyloid
What are these star-shaped things? Are they usually deposited intracellularly, or extracellularly?
A-beta amyloid deposits - extracellular mostly
Name each thingy and what they’re made out of.
- Plaque made from beta-amyloid
- Neurofibrillary tangle made from Tau protein
This is from a brain. What is your diagnosis? What causes this? What are the white spaces called and what used to be there?
Spongiform encephalopathy caused by mutated prion(s). White spaces are vacuoles where neurons used to be.
Is this dystrophic, or metastatic calcification?
Dystrophic
Is this dystrophic, or metastatic calcification?
Dystrophic
Is this dystrophic, or metastatic calcification?
Metastatic calcification
What are those round things? How do they form?
Psamonna bodies - formed via dystrophic calcification in a tumor (this is a meningioma)
