Pathology Picture Cards

Question 1

What is this?

Answer 1

Leiomyoma

Question 2

What is this? What are those things at the tips of the arrows?

Answer 2

Leiomyosarcoma. Areas of necrosis are at the tips of the arrows.

Question 3

Is this a benign, or malignant tumor? Why?

Answer 3

Benign. It is well circumscribed, cells in the tumor look a lot like the cell of origin.

Question 4

What kind of tumor is this?

Answer 4

Teratoma

Question 5

What type of tumor is this? Is it benign, or malignant?

Answer 5

Meningioma, benign (but still dangerous due to mass effect!)

Question 6

What type of epithelium does this look like? Is it neoplastic?

Answer 6

It is urothelium/transitional epithelium - in situ neoplasia. Urothelial cells look like umbrellas - to keep you from getting urinated on!

Question 7

Which side is normal, and which side is neoplastic (in-situ)?

Answer 7

Right side is in-situ neoplasia (cervical)

Question 8

Benign or neoplastic? In-situ or malignant?

Answer 8

In-situ neoplasia

Question 9

Benign or neoplastic? In-situ or malignant?

Answer 9

In-situ neoplasia

Question 10

What is your diagnosis?

Answer 10

Invasive ductal carcinoma

Question 11

Benign or neoplastic? In-situ or malignant?

Answer 11

Normal colonic mucosa

Question 12

Benign or neoplastic? In-situ or malignant?

Answer 12

In-situ neoplasia of the colon

Question 13

Benign or neoplastic? In-situ or malignant?

Answer 13

Invasive carcinoma of the colon

Question 14

Benign or neoplastic? In-situ or malignant?

Answer 14

Normal endometrium

Question 15

What is your diagnosis?

Answer 15

Squamous cell carcinoma. Whorls of keratin are diagnostic for this (see photo)

Question 16

What is your diagnosis?

Answer 16

Colonic adenocarcinoma

Question 17

This is from a biopsy of the uterus. What is your diagnosis?

Answer 17

Leiomyosarcoma. Cells are not differentiated and pleiomorphic. See photo for how smooth muscle should look.

Question 18

What is your diagnosis?

Answer 18

Adenocarcinoma - it is trying to form glands

Question 19

What is your diagnosis?

Answer 19

Melanoma - note the melanin pigments

Question 20

What is your diagnosis?

Answer 20

osteosarcoma

Question 21

What is your diagnosis?

Answer 21

Liposarcoma

Question 22

What is your diagnosis?

Answer 22

Lymphoma

Question 23

One of these is a high-grade breast ductal carcinoma, and one is a low-grade. Which one is which?

Answer 23

Low grade is on the left, high grade is on the right.

Question 24

The slide on the left is from the same organ as the “normal” slide on the right. What is your diagnosis?

Answer 24

Low-grade papillary thyroid carcinoma

Question 25

What is up with this liver?

Answer 25

Cirrhosis

Question 26

This is from a liver biopsy. What is your diagnosis and why?

Answer 26

Cirrhosis. Trichrome stain shows lots of collagen fibers (blue) in between nodules of hepatocytes, which is characteristic of liver cirrhosis.

Question 27

This slide is from a liver biopsy. What are those inclusions? Name a disease in which you would find this.

Answer 27

Iron accumulation in a patient with hereditary hemochromatosis

Question 28

What is up with this pancreas?

Answer 28

Iron accumulation - hereditary hemochromatosis

Question 29

This is from a liver. What are the red spots? What stain was used?

Answer 29

Red spots are fat. Oil red O stain

Question 30

This slide is from the CNS. What is your diagnosis?

Answer 30

Gaucher's disease - accumulation of glucocerebroside

Question 31

Name the cell types (1 and 2). What is the structure labeled #3? What is the stuff surrounding #3?

Answer 31

1. Normal neuron 2. Glial cells 3. Blood vessel 4. Vessel wall full of amyloid - can cause a stroke!

Question 32

Identify the tissue. What are the things marked by arrows?

Answer 32

Cardiac muscle. Lipofuscin

Question 33

This is brain tissue. What stain is used and what is it staining?

Answer 33

Congo red birefringence "Apple Green" stains amyloid

Question 34

What are these star-shaped things? Are they usually deposited intracellularly, or extracellularly?

Answer 34

A-beta amyloid deposits - extracellular mostly

Question 35

Name each thingy and what they're made out of.

Answer 35

1. Plaque made from beta-amyloid 2. Neurofibrillary tangle made from Tau protein

Question 36

This is from a brain. What is your diagnosis? What causes this? What are the white spaces called and what used to be there?

Answer 36

Spongiform encephalopathy caused by mutated prion(s). White spaces are vacuoles where neurons used to be.

Question 37

Is this dystrophic, or metastatic calcification?

Answer 37

Dystrophic

Question 38

Is this dystrophic, or metastatic calcification?

Answer 38

Dystrophic

Question 39

Is this dystrophic, or metastatic calcification?

Answer 39

Metastatic calcification

Question 40

What are those round things? How do they form?

Answer 40

Psamonna bodies - formed via dystrophic calcification in a tumor (this is a meningioma)