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MS1 - MCBD > Autonomic Nervous System Drugs > Flashcards

Autonomic Nervous System Drugs Flashcards

1
Q

Name the mechanism of action and clinical applications…

botulinum toxin

A

cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft

causes muscle spasms, smoothens wrinkles, reduces excessive sweating

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2
Q

Name the mechanism of action and clinical applications…

edrophonium

A

short-acting inhibitor of acetylcholinesterase

used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis

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3
Q

Name the mechanism of action and clinical applications…

pyridostigmine

A

quaternary ammonium carbamate ester acetylcholinesterase inhibitor

treats myasthenia gravis

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4
Q

Name the mechanism of action and clinical applications…

acetylcholine

A

cholinergic agonist (muscarinic and nicotinic)

used for cataract and other eye surgeries

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5
Q

Name the mechanism of action and clinical applications…

tubocurarine chloride (d-tubocucarine)

A

competitive antagonist at skeletal muscle nicotinic receptors

neuromuscular relaxation

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6
Q

Name the mechanism of action and clinical applications…

succinylcholine

A

partial nicotinic agonist; depolarizing neuromuscular blocker

neuromuscular relaxation

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7
Q

Name the mechanism of action and clinical applications…

cevimeline

A

M3 muscarinic agonist

treats Sjogren’s syndrome

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8
Q

Name the mechanism of action and clinical applications…

methacholine

A

non-selective muscarinic agonist

used for Dx of airway hyperreactivity

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9
Q

Name the mechanism of action and clinical applications…

atropine

A

non-selective muscarinic antagonist

Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity

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10
Q

Name the mechanism of action and clinical applications…

darifenacin

A

M3 muscarinic antagonist

treats incontinence or overactive bladder

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11
Q

Name the mechanism of action and clinical applications…

ephedrine

A

mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)

treats hypotension, bronchospasm, nasal decongestant

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12
Q

Name the mechanism of action and clinical applications…

methyldopa (alpha-methyldopa)

A

converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist

treats hypertension

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13
Q

Name the mechanism of action and clinical applications…

albuterol

A

beta-2 agonist

treats acute bronchospasm

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14
Q

Name the mechanism of action and clinical applications…

clonidine

A

CNS alpha-2 agonist, resulting in decreased sympathetic outflow

treats hypertension

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15
Q

Name the mechanism of action and clinical applications…

dobutamine

A

beta-1 agonist

increases cardiac output for heart failure patients

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16
Q

Name the mechanism of action and clinical applications…

dopamine

A

dopamine agonist

helps patients with shock, especially with renal shutdown; sometimes used in heart failure

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17
Q

Name the mechanism of action and clinical applications…

epinephrine

A

adrenergic agonist

treats anaphylaxis and is an emergency treatment for cardiac arrest

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18
Q

Name the mechanism of action and clinical applications…

isoproterenol

A

non-selective beta-adrenergic agonist

treats asthma and is an emergency treatment for cardiac arrest

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19
Q

Name the mechanism of action and clinical applications…

midodrine

A

alpha-1 agonist

treats chronic orthostatic hypotension

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20
Q

Name the mechanism of action and clinical applications…

phenylephrine

A

alpha-adrenergic agonist

decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex

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21
Q

Name the mechanism of action and clinical applications…

carvedilol

A

antagonist at alpha-1 and beta adrenergic receptors

treats hypertension, heart failure

22
Q

Name the mechanism of action and clinical applications…

metroprolol

A

beta-1 antagonist

treats hypertension, heart failure

23
Q

Name the mechanism of action and clinical applications…

phentolamine

A

alpha adrenergic antagonist

treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antidote to overdose of adrenergic agonists

24
Q

Name the mechanism of action and clinical applications…

prazosin

A

alpha-1 antagonist

treats hypertension, benign prostatic hyperplasia

25
Name the mechanism of action and clinical applications... propranolol
non-selective beta adrenergic antagonist treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine Howard took some for his UW interview! They're doooope!
26
# name the drug! cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft causes muscle spasms, smoothens wrinkles, reduces excessive sweating
botulinum toxin
27
# name the drug! short-acting inhibitor of acetylcholinesterase used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis
edrophonium
28
# name the drug! quaternary ammonium carbamate ester acetylcholinesterase inhibitor treats myasthenia gravis
pyridostigmine
29
# name the drug! cholinergic agonist (muscarinic and nicotinic) used for cataract and other eye surgeries
acetylcholine
30
# name the drug! competitive antagonist at skeletal muscle nicotinic receptors neuromuscular relaxation
tubocurarine chloride (d-tubocucarine)
31
# name the drug! partial nicotinic agonist; depolarizing neuromuscular blocker neuromuscular relaxation
succinylcholine
32
# name the drug! M3 muscarinic agonist treats Sjogren's syndrome
cevimeline
33
# name the drug! non-selective muscarinic agonist used for Dx of airway hyperreactivity
methacholine
34
# name the drug! non-selective muscarinic antagonist Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity
atropine
35
# name the drug! M3 muscarinic antagonist treats incontinence or overactive bladder
darifenacin
36
# name the drug! mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist) treats hypotension, bronchospasm, nasal decongestant
ephedrine
37
# name the drug! converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist treats hypertension
methyldopa (alpha-methyldopa)
38
# name the drug! beta-2 agonist treats acute bronchospasm
albuterol
39
# name the drug! CNS alpha-2 agonist, resulting in decreased sympathetic outflow treats hypertension
clonidine
40
# name the drug! beta-1 agonist increases cardiac output for heart failure patients
dobutamine
41
# name the drug! dopamine agonist helps patients with shock, especially with renal shutdown; sometimes used in heart failure
dopamine
42
# name the drug! adrenergic agonist treats anaphylaxis and is an emergency treatment for cardiac arrest
epinephrine
43
# name the drug! non-selective beta-adrenergic agonist treats asthma and is an emergency treatment for cardiac arrest
isoproterenol
44
# name the drug! alpha-1 agonist treats chronic orthostatic hypotension
midodrine
45
# name the drug! alpha-adrenergic agonist decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex
phenylephrine
46
# name the drug! antagonist at alpha-1 and beta adrenergic receptors treats hypertension, heart failure
carvedilol
47
# name the drug! beta-1 antagonist treats hypertension, heart failure
metroprolol
48
# name the drug! alpha adrenergic antagonist treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antitode to overdose of adrenergic agonists
phentolamine
49
# name the drug! alpha-1 antagonist treats hypertension, benign prostatic hyperplasia
prazosin
50
# name the drug! non-selective beta adrenergic antagonist treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine Howard took some for his UW interview! They're doooope!
propranolol

MS1 - MCBD (17 decks)

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