Autonomic Nervous System Drugs Flashcards
Name the mechanism of action and clinical applications…
botulinum toxin
cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft
causes muscle spasms, smoothens wrinkles, reduces excessive sweating
Name the mechanism of action and clinical applications…
edrophonium
short-acting inhibitor of acetylcholinesterase
used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis
Name the mechanism of action and clinical applications…
pyridostigmine
quaternary ammonium carbamate ester acetylcholinesterase inhibitor
treats myasthenia gravis
Name the mechanism of action and clinical applications…
acetylcholine
cholinergic agonist (muscarinic and nicotinic)
used for cataract and other eye surgeries
Name the mechanism of action and clinical applications…
tubocurarine chloride (d-tubocucarine)
competitive antagonist at skeletal muscle nicotinic receptors
neuromuscular relaxation
Name the mechanism of action and clinical applications…
succinylcholine
partial nicotinic agonist; depolarizing neuromuscular blocker
neuromuscular relaxation
Name the mechanism of action and clinical applications…
cevimeline
M3 muscarinic agonist
treats Sjogren’s syndrome
Name the mechanism of action and clinical applications…
methacholine
non-selective muscarinic agonist
used for Dx of airway hyperreactivity
Name the mechanism of action and clinical applications…
atropine
non-selective muscarinic antagonist
Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity
Name the mechanism of action and clinical applications…
darifenacin
M3 muscarinic antagonist
treats incontinence or overactive bladder
Name the mechanism of action and clinical applications…
ephedrine
mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)
treats hypotension, bronchospasm, nasal decongestant
Name the mechanism of action and clinical applications…
methyldopa (alpha-methyldopa)
converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist
treats hypertension
Name the mechanism of action and clinical applications…
albuterol
beta-2 agonist
treats acute bronchospasm
Name the mechanism of action and clinical applications…
clonidine
CNS alpha-2 agonist, resulting in decreased sympathetic outflow
treats hypertension
Name the mechanism of action and clinical applications…
dobutamine
beta-1 agonist
increases cardiac output for heart failure patients
Name the mechanism of action and clinical applications…
dopamine
dopamine agonist
helps patients with shock, especially with renal shutdown; sometimes used in heart failure
Name the mechanism of action and clinical applications…
epinephrine
adrenergic agonist
treats anaphylaxis and is an emergency treatment for cardiac arrest
Name the mechanism of action and clinical applications…
isoproterenol
non-selective beta-adrenergic agonist
treats asthma and is an emergency treatment for cardiac arrest
Name the mechanism of action and clinical applications…
midodrine
alpha-1 agonist
treats chronic orthostatic hypotension
Name the mechanism of action and clinical applications…
phenylephrine
alpha-adrenergic agonist
decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex
Name the mechanism of action and clinical applications…
carvedilol
antagonist at alpha-1 and beta adrenergic receptors
treats hypertension, heart failure
Name the mechanism of action and clinical applications…
metroprolol
beta-1 antagonist
treats hypertension, heart failure
Name the mechanism of action and clinical applications…
phentolamine
alpha adrenergic antagonist
treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antidote to overdose of adrenergic agonists
Name the mechanism of action and clinical applications…
prazosin
alpha-1 antagonist
treats hypertension, benign prostatic hyperplasia
Name the mechanism of action and clinical applications…
propranolol
non-selective beta adrenergic antagonist
treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine Howard took some for his UW interview! They’re doooope!
name the drug!
cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft
causes muscle spasms, smoothens wrinkles, reduces excessive sweating
botulinum toxin
name the drug!
short-acting inhibitor of acetylcholinesterase
used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis
edrophonium
name the drug!
quaternary ammonium carbamate ester acetylcholinesterase inhibitor
treats myasthenia gravis
pyridostigmine
name the drug!
cholinergic agonist (muscarinic and nicotinic)
used for cataract and other eye surgeries
acetylcholine
name the drug!
competitive antagonist at skeletal muscle nicotinic receptors
neuromuscular relaxation
tubocurarine chloride (d-tubocucarine)
name the drug!
partial nicotinic agonist; depolarizing neuromuscular blocker
neuromuscular relaxation
succinylcholine
name the drug!
M3 muscarinic agonist
treats Sjogren’s syndrome
cevimeline
name the drug!
non-selective muscarinic agonist
used for Dx of airway hyperreactivity
methacholine
name the drug!
non-selective muscarinic antagonist
Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity
atropine
name the drug!
M3 muscarinic antagonist
treats incontinence or overactive bladder
darifenacin
name the drug!
mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)
treats hypotension, bronchospasm, nasal decongestant
ephedrine
name the drug!
converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist
treats hypertension
methyldopa (alpha-methyldopa)
name the drug!
beta-2 agonist
treats acute bronchospasm
albuterol
name the drug!
CNS alpha-2 agonist, resulting in decreased sympathetic outflow
treats hypertension
clonidine
name the drug!
beta-1 agonist
increases cardiac output for heart failure patients
dobutamine
name the drug!
dopamine agonist
helps patients with shock, especially with renal shutdown; sometimes used in heart failure
dopamine
name the drug!
adrenergic agonist
treats anaphylaxis and is an emergency treatment for cardiac arrest
epinephrine
name the drug!
non-selective beta-adrenergic agonist
treats asthma and is an emergency treatment for cardiac arrest
isoproterenol
name the drug!
alpha-1 agonist
treats chronic orthostatic hypotension
midodrine
name the drug!
alpha-adrenergic agonist
decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex
phenylephrine
name the drug!
antagonist at alpha-1 and beta adrenergic receptors
treats hypertension, heart failure
carvedilol
name the drug!
beta-1 antagonist
treats hypertension, heart failure
metroprolol
name the drug!
alpha adrenergic antagonist
treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antitode to overdose of adrenergic agonists
phentolamine
name the drug!
alpha-1 antagonist
treats hypertension, benign prostatic hyperplasia
prazosin
name the drug!
non-selective beta adrenergic antagonist
treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine
Howard took some for his UW interview! They’re doooope!
propranolol
