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MS1 - MCBD > Autonomic Nervous System Drugs > Flashcards

Autonomic Nervous System Drugs Flashcards

1
Q

Name the mechanism of action and clinical applications…

botulinum toxin

A

cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft

causes muscle spasms, smoothens wrinkles, reduces excessive sweating

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2
Q

Name the mechanism of action and clinical applications…

edrophonium

A

short-acting inhibitor of acetylcholinesterase

used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis

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3
Q

Name the mechanism of action and clinical applications…

pyridostigmine

A

quaternary ammonium carbamate ester acetylcholinesterase inhibitor

treats myasthenia gravis

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4
Q

Name the mechanism of action and clinical applications…

acetylcholine

A

cholinergic agonist (muscarinic and nicotinic)

used for cataract and other eye surgeries

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5
Q

Name the mechanism of action and clinical applications…

tubocurarine chloride (d-tubocucarine)

A

competitive antagonist at skeletal muscle nicotinic receptors

neuromuscular relaxation

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6
Q

Name the mechanism of action and clinical applications…

succinylcholine

A

partial nicotinic agonist; depolarizing neuromuscular blocker

neuromuscular relaxation

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7
Q

Name the mechanism of action and clinical applications…

cevimeline

A

M3 muscarinic agonist

treats Sjogren’s syndrome

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8
Q

Name the mechanism of action and clinical applications…

methacholine

A

non-selective muscarinic agonist

used for Dx of airway hyperreactivity

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9
Q

Name the mechanism of action and clinical applications…

atropine

A

non-selective muscarinic antagonist

Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity

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10
Q

Name the mechanism of action and clinical applications…

darifenacin

A

M3 muscarinic antagonist

treats incontinence or overactive bladder

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11
Q

Name the mechanism of action and clinical applications…

ephedrine

A

mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)

treats hypotension, bronchospasm, nasal decongestant

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12
Q

Name the mechanism of action and clinical applications…

methyldopa (alpha-methyldopa)

A

converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist

treats hypertension

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13
Q

Name the mechanism of action and clinical applications…

albuterol

A

beta-2 agonist

treats acute bronchospasm

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14
Q

Name the mechanism of action and clinical applications…

clonidine

A

CNS alpha-2 agonist, resulting in decreased sympathetic outflow

treats hypertension

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15
Q

Name the mechanism of action and clinical applications…

dobutamine

A

beta-1 agonist

increases cardiac output for heart failure patients

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16
Q

Name the mechanism of action and clinical applications…

dopamine

A

dopamine agonist

helps patients with shock, especially with renal shutdown; sometimes used in heart failure

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17
Q

Name the mechanism of action and clinical applications…

epinephrine

A

adrenergic agonist

treats anaphylaxis and is an emergency treatment for cardiac arrest

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18
Q

Name the mechanism of action and clinical applications…

isoproterenol

A

non-selective beta-adrenergic agonist

treats asthma and is an emergency treatment for cardiac arrest

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19
Q

Name the mechanism of action and clinical applications…

midodrine

A

alpha-1 agonist

treats chronic orthostatic hypotension

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20
Q

Name the mechanism of action and clinical applications…

phenylephrine

A

alpha-adrenergic agonist

decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex

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21
Q

Name the mechanism of action and clinical applications…

carvedilol

A

antagonist at alpha-1 and beta adrenergic receptors

treats hypertension, heart failure

22
Q

Name the mechanism of action and clinical applications…

metroprolol

A

beta-1 antagonist

treats hypertension, heart failure

23
Q

Name the mechanism of action and clinical applications…

phentolamine

A

alpha adrenergic antagonist

treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antidote to overdose of adrenergic agonists

24
Q

Name the mechanism of action and clinical applications…

prazosin

A

alpha-1 antagonist

treats hypertension, benign prostatic hyperplasia

25
Q

Name the mechanism of action and clinical applications…

propranolol

A

non-selective beta adrenergic antagonist

treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine Howard took some for his UW interview! They’re doooope!

26
Q

name the drug!

cleaves SNARE proteins to keep vesicles containing ACh from fusing with the PM and going into the cleft

causes muscle spasms, smoothens wrinkles, reduces excessive sweating

A

botulinum toxin

27
Q

name the drug!

short-acting inhibitor of acetylcholinesterase

used to reverse a neuromuscular block by nondepolarizing drugs; aids in diagnosis of myasthenia gravis

A

edrophonium

28
Q

name the drug!

quaternary ammonium carbamate ester acetylcholinesterase inhibitor

treats myasthenia gravis

A

pyridostigmine

29
Q

name the drug!

cholinergic agonist (muscarinic and nicotinic)

used for cataract and other eye surgeries

A

acetylcholine

30
Q

name the drug!

competitive antagonist at skeletal muscle nicotinic receptors

neuromuscular relaxation

A

tubocurarine chloride (d-tubocucarine)

31
Q

name the drug!

partial nicotinic agonist; depolarizing neuromuscular blocker

neuromuscular relaxation

A

succinylcholine

32
Q

name the drug!

M3 muscarinic agonist

treats Sjogren’s syndrome

A

cevimeline

33
Q

name the drug!

non-selective muscarinic agonist

used for Dx of airway hyperreactivity

A

methacholine

34
Q

name the drug!

non-selective muscarinic antagonist

Mydriatic (dilates pupils), cycloplegic (paralyzes the ciliary muscle); reversal of vagal bradycardia; antitode for cholinesterase inhibitor toxicity

A

atropine

35
Q

name the drug!

M3 muscarinic antagonist

treats incontinence or overactive bladder

A

darifenacin

36
Q

name the drug!

mixed-acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)

treats hypotension, bronchospasm, nasal decongestant

A

ephedrine

37
Q

name the drug!

converted to methylnorepinephrine in the CNS, which acts like an alpha-2 agonist

treats hypertension

A

methyldopa (alpha-methyldopa)

38
Q

name the drug!

beta-2 agonist

treats acute bronchospasm

A

albuterol

39
Q

name the drug!

CNS alpha-2 agonist, resulting in decreased sympathetic outflow

treats hypertension

A

clonidine

40
Q

name the drug!

beta-1 agonist

increases cardiac output for heart failure patients

A

dobutamine

41
Q

name the drug!

dopamine agonist

helps patients with shock, especially with renal shutdown; sometimes used in heart failure

A

dopamine

42
Q

name the drug!

adrenergic agonist

treats anaphylaxis and is an emergency treatment for cardiac arrest

A

epinephrine

43
Q

name the drug!

non-selective beta-adrenergic agonist

treats asthma and is an emergency treatment for cardiac arrest

A

isoproterenol

44
Q

name the drug!

alpha-1 agonist

treats chronic orthostatic hypotension

A

midodrine

45
Q

name the drug!

alpha-adrenergic agonist

decongestant, mydriatic (dilates pupils), treats neurogenic/orthostatic hypotension, tests the baroreflex

A

phenylephrine

46
Q

name the drug!

antagonist at alpha-1 and beta adrenergic receptors

treats hypertension, heart failure

A

carvedilol

47
Q

name the drug!

beta-1 antagonist

treats hypertension, heart failure

A

metroprolol

48
Q

name the drug!

alpha adrenergic antagonist

treats phaeochromocytoma (adrenal gland tumor that secretes catecholamines), antitode to overdose of adrenergic agonists

A

phentolamine

49
Q

name the drug!

alpha-1 antagonist

treats hypertension, benign prostatic hyperplasia

A

prazosin

50
Q

name the drug!

non-selective beta adrenergic antagonist

treats angina, arrhythmias (tx and prophylaxis), hypertension, tremor, stage fright, migraine

Howard took some for his UW interview! They’re doooope!

A

propranolol

MS1 - MCBD (17 decks)

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