Pathology Pics Flashcards
normal thyroid
normal thyroid
interstitium not prominent
normal thyroid
IHC stain for C/parafollicular cells
Thyroid
Hashimoto Thyroiditis
chronic inflammation of T lymphocytes, follicular germinal centers
remaining tissue atrophied, hurthle (follicular cells with more cytoplasm) cell change
risk of developing B cell lymphoma
Thyroid
Hashimotos
Hurthle cells (follicular origin) and lymphocytes
Thyroid
follicular cells
follicular adenoma
Thyroid gland
Hashimoto’s thyroiditis
Thyroid
subacute granulomatous (de Quervain) thyroiditis
multinucleated giant cell, lymphocytes, macrophages, follicle destruction
Fine needle aspiration of thyroid
subacute lymphocytic thyroiditis (painless thyroiditis- variant of Hashimoto’s)
lymphocytes, macrophages, normal thyroid epithelial cells, a few damaged thyroid follicles, masses of colloid
recovery: mild fibrosis, lymphocytes persist, normal follicles
Thyroid
Riedel thyroiditis
FIBROSIS, lymphocytes, hyperplastic germinal centers (none here)
Thyroid
Graves Disease
hyperplasia characterized by papillary infoldings
Thyroid
Graves disease
tall columnar appearance with vacuoles: scalloped edge
goiter
left and middle: starts as diffuse thyroid enlargement
right: progresses to multinodular state
Thyroid.
You cut it and it leaks fluid.
multinodular goiter
gross: coarsely nodular gland with fibrosis and cystic change
histo: hyperplastic nodule with compressed residual thyroid parenchyma
NO capsule
follicular adenoma
Thyroid
follicular adenoma
distinct from adjacent non-neoplastic thyroid; neoplastic cells have little variation in cell size, shape or nuclear morphology
Thyroid
Hurthle cell adenoma
Thyroid
follicular carcinoma
left: breach capsule
right: vessel invasion
Thyroid
papillary carcinoma
psammoma bodies
papillae with fibrovascular stalk covered by cuboidal epithelial cells
nuclear features: ORPHAN ANNIE: optically clear, empty intranuclear grooves, pseudoinclusions
Thyroid
Papillary carcinoma
blue: pseudoinclusions
green: optically clear
black: intranuclear groove
Thyroid
papillary carcinoma: tall cell variant
cells twice as tall as wide compromise 50% of tumor
abundant eosinophilic cytoplasm and papillary nuclear features
Thyroid
anaplastic carcinoma
large, pleomorphic multinucleated giant cells
spindle cells with sarcomatous appearance
Thyroid
medullary carcinoma
polygonal to spindle shaped cells that form nests, trabeculae, and follicles
Thyroid
medullary carcinoma
amyloid deposits in stroma
