Pathology of vasculitis Flashcards
Symptoms of vasculitis
fever, myalgias, arthralgias, malaise
Signs of vasculitis
palpable purpura, focal skin necrosis, ulceration, livedo reticularis, urticaria, myositis, peripheral neuropathy, GI ulcers/perforations, intussusception. pancreatitis, hemoptysis, nodular pulmonary infiltrates, hematuria, proteinuria, organ ischemia/infarction
_____ is network pattern purplish discoloration of skin due to dilation of blood vessels.
Livedo reticularis
Signs and symptoms of vasculitis are nonspecific. Vasculitis is a _____ diagnosis.
biopsy
What are key features to the specific diagnosis of vasculitis?
distribution of organ involvement, histopathological features
Describe the inflammation of temporal arteritis
Segmental, transmural, and granulomatous with multinucleated giant cells centering on internal elastic lamina destroying it. Plus lymphocytes, intimal thickening, cell proliferation, luminal stenosis
What are the most common clinical manifestations of temporal arteritis?
- headache, swollen tender artery, scalp tenderness, visual disturbances, jaw claudication, fevere, malaise, weight loss
Describe the inflammation of takayasau arteritis.
Segmental, transmural, necrotizing, loosely granulomatous with multinucleated giant cells with lymphocytes, intimal thickening and adventitial thickening, medial loss of elastic fibers, luminal stenosis
Describe the pathology of polyarteritis nodosa.
segmental, transmural, nodular with fibrinoid necrosis.
Neutrophils in acute phase, intimal thickening, cell proliferation and degeneration, luminal stenosis, may have thrombosis, occlusion, or rupture all at branchpoints.
Describe the later pathology of polyarteritis nodosa
chronic inflammation, fibroblasts, scarring maybe with aneurysm.
Are polyarteritis nodosa lesions hetero or homogenous
hetero
What stage of polyarteritis nodosa looks like there are ants crawling all over an artery?
Acute
Do you see livedo reticularis in polyarteritis nodosa?
yes
