Pathology of Uterus, Endometrium, and Fallopian Tubes

Question 1

Acute Endometritis

• Eti
• S/S

Answer 1

• Eti: Infx, Abortion, instrumentation
• S/S: Pelvic pain, dysmenorrhea, menstrual abnormalities, purulent vaginal discharge, acute abdomen, peritonitis, thrombophlebitis, PR

Question 2

Chronic endomitritis

• Eti
• LabDx

Answer 2

• Eti:Chronic PID, abortion, postpartum, IUD, TB

- LabDx: Plasma cells in endometrial Stroma

Question 3

Adenomyosis

• S/S
• Path
• LabDx

Answer 3

• S/S: Menorrhagia, dysmenorrhea, dyspareunia, pelvic pain
• Path: Smooth muscle hypertrophy around endometrial foci
• LabDx: Glands/Stroma as least 3 mm beneath endometrium

Question 4

Benign Epithelial Polyps

• S/S
• Progression/Complications

Answer 4

• S/S: Asymptomatic or abnormal bleeding

- P/C: Malignant change RARE; Tip can ulcerate/necrotize and bleed

Question 5

Type I Endometrial Carcinoma

• Risk factors
• Genetics
• LabDx

Answer 5

• Risk factors: Obestiy/diabetes; HTN; infertility unopposed estrogen
• G: PTEN mutation -> PI3K/AKT pathway
• LabDx: Localized polypoid, fungating tumor or diffusely infiltrating

Question 6

Type II Endometiral Carcinoma

• Types
• Genetics

Answer 6

• T: Serous; clear cell; malignant mixed

- G: TP53

Question 7

Common cause of bilateral hydrosalpinges

Answer 7

TB