Pathology of Respiratory Flashcards
What symptom must be present for someone to have asthma?
Wheezing
If a patient doesn’t have wheezing what is definitely not the diagnosis?
Asthma
Does asthma have a definition?
No
Is asthma variable or non-variable?
Very variable
In children is asthma more predominant in girls or boys?
Boys
In adults is asthma more predominant in males of females?
Females
How many causative hits does asthma require?
Several
Give examples of hits that can lead to asthma?
Genes
Abnormal lungs
Early onset atopy
Later exposures (virus, exercise, smoking)
What is the best way to diagnose a child with asthma?
A history
When taking a family history for asthma who should be asked about?
Parents
Is there any asthma test for children?
No
Why is an examination not very useful in the diagnosis of asthma?
Because asthma is episodic
Person is unlikely to be going through episode at the time of the examination
Out of every 4 positive allergy tests how many children are then asthmatic?
1
Why is coughing not a very relevant for asthma diagnosis?
Because whilst coughing is a sign of asthma
EVERYONE coughs
Is asthma obstructive or restrictive?
Obstructive
After asking if a child wheezes what is best to then identify?
If it is genuine wheezing
When is shortness of breath a bad sign?
When it occurs at rest
What antibody type is atopy referring to?
IgE
If the patient responds to asthma treatment are they likely to have asthma?
Yes
What sounds could be mistaken for wheezing?
Rattle
Stertor
What is the risk of treating a child with suspected bacterial bronchitis?
Them experiencing diarrhoea
What is the only problem that will induce a colour change and why?
Pertussis
Burst blood vessels from coughing
How do you confirm a diagnosis for asthma?
Trial them on ICS
Inhaled steroid treatment
Is there a lower age limit for diagnosing asthma?
No
Is there a test for diagnosing asthma in children?
No
What is COPD characterised by?
Airflow obstuction
Does COPD change markedly overall several months?
No
What does C in COPD stand for?
Chronic
What is asthma?
Airway inflammation mediated by the immune system
What mediates the airway inflammation in asthma?
Immune system
Is the airway narrowing in asthma spontaneous or brought on by stimuli?
Can be either
What is emphysema?
The destruction of the alveoli leading to a loss of elasticity
Is asthma more common in boys or girls?
Boys
Is asthma moe common in women or men?
Women
What is the prevalence of asthma in children?
10-15%
What is the prevalence of asthma in adults?
5-10%
What factors can lead to asthma?
Atopy Smoking (maternal and grandmother effect) Certain genes Airway development genes Occupation
When does wheezing occur?
When the airways are narrowed
Is the lung function in asthma fixed?
Yes
Is it common to wheeze?
Yes
During coughs, cold or similar viral infections
With wheezing what are you trying to differentiate?
If the wheeze is caused by asthma
Or as a result of other causes of airway obstruction
In asthma are the airways always obstructed?
No - comes in period
What is bronchospasm?
When the smooth muscle of the airways contract - narrowing them
What percent of children grow out of asthma?
2 out of 3
As you age does lung function increase or decrease?
Decreases
What is bronchiectasis?
Abnormal widening of one or more airways
In the abnormal airways in bronchiectasis what extra is made?
Extra mucus
Making it prone to infection
Why is asthma so important?
Because so many people have it
Give some examples of possible risk factors of asthma
Obesity
Diet
Reduced exposure to microbes
Indoor pollution
What are the main symptoms of asthma?
WHEEZING Shortness of breath (dyspnoea) Chest tightness Cough (usually dry) Sputum
What is the usual character of a cough in asthma?
Dry
What is dyspnoea?
Shortness of breath
How many people die from lung cancer each year in the UK?
35000
What is the 5 year survival rate of lung cancer?
8%
Is the global incidence of lung caner rising or descending?
Rising
What is the biggest contributor to lung cancer?
Smoking
What is the most common cause of lung cancer?
Smoking
Does stopping smoker help your risk with lung cancer?
The risk will decline
Give example of genes mutations that increase the risk of lung cancer
KRAs
EGFR
BRAF
HER2
To develop cancer is one mutation needed?
No several
Multiple hit hypothesis
What are some of the symptoms of lung cancer?
Cough Haemoptysis Chest pain Breathlessness Weight loss Wheeze Swollen face/neck Finger clubbing
What is a sign of lung cancer tht can be seen on the hands?
Finger clubbing
What is haemoptysis?
Coughing up blood
What are some of the metastatic symptoms of lung cancer?
Bone pain
Headaches
Neurologica fits
Jaundice
What are the two types of tumours?
Benign
Malignant
What is the most aggressive form of lung cancer?
Small cell carcinoma
What are the characteristics of small cell carcinoma?
Large tumours
Quick growing
Often metastasis before diagnosis
What are some of the other contributors to lung cancer?
Environmental radon
Air pollution and urban life
Asbestos exposure
With smoking and cancer what is the degree of risk related to?
To the volume of consumption
Give examples of lower respiratory tract infections
Bronchitis
Bronchiolitis
Pneumonia
What is the function of the macrophage-mucociliary escalator system?
To keep bad stuff out
Act like a filter
Sweep pathogens out
Is the lower respiratory tract sterile?
Normally yes