Pathology Of Primary And Secondary Hyperparthyroidism

Question 1

Hyperparathyroidism = overproduction of

Answer 1

PTH

Question 2

Primary hyperparathyroidism is defined as

Answer 2

Abnormality in parathyroid gland itself that results in excess PTH

Question 3

Secondary hyperparathyroidism is defined as

Answer 3

An external cause that results in excess PTH

Question 4

Secondary hyperparathyroidism can be due to 2 processes:

Answer 4

Chronic renal disease

Nutritional deficiencies

Question 5

Primary hyperparathyroidism can be a result of 3 types of growths:

Answer 5

1. Parathyroid nodular hyperplasia
2. Parathyroid adenoma
3. Parathyroid carcinoma

Question 6

Parathyroid adenomas are more common than carcinomas. True or false?

Answer 6

True

Question 7

Parathyroid adenomas and parathyroid carcinomas are ______ _____ neoplasms

Answer 7

Chief cell

Question 8

Tumors on the paraythroid gland are _____ tumors, and the effects are from increased PTH, not mass effects

Answer 8

Functional!

Tumors secrete PTH

Question 9

2 clin path findings with primary hyperparathyroidism?

Answer 9

Hypercalcemia

Hypophosphatemia

Question 10

Renal secondary hyperparathyroidism is defined as:

Answer 10

Excessive PTH production due to CKD

Question 11

Nutritional secondary hyperparathyroidism is induced by diets low in _______ and high in _______

Answer 11

Calcium

Phosphate

Improper Ca:P ratio

Question 12

Hypocalcemia stimulates ________ __________

Answer 12

Parathyroid hyperplasia

Question 13

Fibrous osteodystrophy occurs when increased PTH causes osteoclastic resorption of bone and that bone is replaced by _________ __________ __________

Answer 13

Fibrous connective tissue

Question 14

Fibrous osteodystrophy is usually a result of _______ _________ ____________

Answer 14

Nutritional secondary hyperparathyroidism