Pathology Of Humoral Hypercalcemia Of Malignancy

Question 1

3 causes for hypercalcemia secondary to neoplasia

Answer 1

Metastasis to bone

Humoral hypercalcemia of malignancy

Hematological malignancies localize to bone

Question 2

Define humoral hypercalcemia of malignancy

Answer 2

Neoplastic cells produce humoral factors that contribute to hypercalcemia

Question 3

3 neoplasias that can cause humoral hypercalcemia of malignancy?

Answer 3

Apocrine gland adenocarcinoma of the anal sac

T-cell lymphoma

Multiple myeloma

Question 4

PTHrP mediated hypercalcemia is the most common cause of

Answer 4

Humoral hypercalcemia of malignancy

Question 5

PTHrp has 3 key points to its MOA:

Answer 5

1. Stimulates osteoclastic bone resorption
2. Increased calcium reabsorption from the kidneys
3. Increased calcium absorption from the intestine