Pathology of Ovary, FT, Peritoneum Flashcards
Primordial germ cells (endoderm) arise in wall of yolk sac by ____ week of gestation and migrate to urogenital ridge by ____ weeek
4th, 6th
Where does the majority of the blood supply run for the ovary?
hilus
What structures initially maintains progesterone to maintain pregnancy?
??
Corpus luteum initially (maintained by HCG ),
then fetus
most common cause of hematosalpinx
ectopic pregnancy
- usually appear w/ abd pain ~6 weeks
If pts use IUD as contraception, they are at rish for ____ if they get pregnant
ectopic preg
Endometriosis (extrauterine endomet glands and stroma) affects ___% of women, and can result in___.
10%
Infertility, dysmenorrhea, pelvic pain
What is the persistent anovulation seen in PCOS due to?
asynchronous release of FSH and LH
*rx: early interv, and metformin
PCOS is a risk factor for?
unopposed E2 is a risk for endometrial carcinoma
5th leading cause of cancer related death in women
ovarian cancer
Things that reduce risk of ovarian cancer
- Oral contraceptives
- Full term pregnancy
- Gynecologic surgery
- breast feeding
Risk factors for ovarian cancer
- Infertility
- Unopposed E for >10 years
- 1st or 2nd degree fam hx
Lynch syndrome has ___% risk of ovarian cancer and ____% for uterin cancer
12% - ovarian
40-60% - uterine
Origin of most epithelial ovarian tumors are now believed to be ______ of _____
fimbriated end of fallopian tube
Surface epithelial - stromal cell tumors
- serous tumor
- Mucinous tumor
- Endometriod tumor
- Clear cell tumor
- Brenner tumor
- Cystadenoma
- can be type I (progression) or type II (sporadic/de novo)
- can be benign, borderline or malignant
Germ cell tumors
- teratoma
- dysgerminoma
- endodermal sinus tumor
- choriocarcinoma
sex cord stroma
- fibroma
- granulosa-theca cell tumor
- sertoli - leydig cell tumor
Hallmark of serous borderline tumor
heirarchical branching: big, smaller, smallest devel of epith cells.
- no stromal invasion
- psammoma bodies
Tubulocystic growth patterns + Hobnail cells (nuclei bulding into cystic space w/o apparent cytoplasm)
Clear cell carcinoma
Hierarchical branching and psammoma bodies
serous neoplasms
goblet cells
mucinous tumors
endometrioid tumors resembles uterine _____
adenocarcinoma
Unlike males, mature cystic teratoma in any age women is _____ (benign or malignant?)
benign
Unlike males, mixed GCT are ______ (rare/common)
rare
- 10-15% in ovaries
- 32-60% in testes
Most common ovarian GCT
mature cystic teratoma
- mature = no spread
- teratoma = any tissue that can be seen in a fetus
(teeth, hair ect)
