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Unit 1 ID+LC > Pathology of Ovary, FT, Peritoneum > Flashcards

Pathology of Ovary, FT, Peritoneum Flashcards

1
Q

Primordial germ cells (endoderm) arise in wall of yolk sac by ____ week of gestation and migrate to urogenital ridge by ____ weeek

A

4th, 6th

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2
Q

Where does the majority of the blood supply run for the ovary?

A

hilus

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3
Q

What structures initially maintains progesterone to maintain pregnancy?

A

??
Corpus luteum initially (maintained by HCG ),

then fetus

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4
Q

most common cause of hematosalpinx

A

ectopic pregnancy

- usually appear w/ abd pain ~6 weeks

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5
Q

If pts use IUD as contraception, they are at rish for ____ if they get pregnant

A

ectopic preg

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6
Q

Endometriosis (extrauterine endomet glands and stroma) affects ___% of women, and can result in___.

A

10%

Infertility, dysmenorrhea, pelvic pain

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7
Q

What is the persistent anovulation seen in PCOS due to?

A

asynchronous release of FSH and LH

*rx: early interv, and metformin

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8
Q

PCOS is a risk factor for?

A

unopposed E2 is a risk for endometrial carcinoma

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9
Q

5th leading cause of cancer related death in women

A

ovarian cancer

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10
Q

Things that reduce risk of ovarian cancer

A
  1. Oral contraceptives
  2. Full term pregnancy
  3. Gynecologic surgery
  4. breast feeding
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11
Q

Risk factors for ovarian cancer

A
  1. Infertility
  2. Unopposed E for >10 years
  3. 1st or 2nd degree fam hx
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12
Q

Lynch syndrome has ___% risk of ovarian cancer and ____% for uterin cancer

A

12% - ovarian

40-60% - uterine

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13
Q

Origin of most epithelial ovarian tumors are now believed to be ______ of _____

A

fimbriated end of fallopian tube

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14
Q

Surface epithelial - stromal cell tumors

A
  1. serous tumor
  2. Mucinous tumor
  3. Endometriod tumor
  4. Clear cell tumor
  5. Brenner tumor
  6. Cystadenoma
  • can be type I (progression) or type II (sporadic/de novo)
  • can be benign, borderline or malignant
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15
Q

Germ cell tumors

A
  1. teratoma
  2. dysgerminoma
  3. endodermal sinus tumor
  4. choriocarcinoma
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16
Q

sex cord stroma

A
  1. fibroma
  2. granulosa-theca cell tumor
  3. sertoli - leydig cell tumor
17
Q

Hallmark of serous borderline tumor

A

heirarchical branching: big, smaller, smallest devel of epith cells.

  • no stromal invasion
  • psammoma bodies
18
Q

Tubulocystic growth patterns + Hobnail cells (nuclei bulding into cystic space w/o apparent cytoplasm)

A

Clear cell carcinoma

19
Q

Hierarchical branching and psammoma bodies

A

serous neoplasms

20
Q

goblet cells

A

mucinous tumors

21
Q

endometrioid tumors resembles uterine _____

A

adenocarcinoma

22
Q

Unlike males, mature cystic teratoma in any age women is _____ (benign or malignant?)

A

benign

23
Q

Unlike males, mixed GCT are ______ (rare/common)

A

rare

  • 10-15% in ovaries
  • 32-60% in testes
24
Q

Most common ovarian GCT

A

mature cystic teratoma
- mature = no spread
- teratoma = any tissue that can be seen in a fetus
(teeth, hair ect)

25
Q

Immature teratoma in women is always _____

A

malignant

26
Q

Most common malignant stromal tumor

A

granulosa cell tumor

  • malignant
  • call-exner
27
Q

Most common malignant GCT in adolescents

- name the male tumor counterpart

A

Dysgerminoma
- malignant

  • female counterpart to seminoma
28
Q

TUmor marker for Yolk sac tumor

A

AFP

- malignant

29
Q

Schiller-Duval body

A

Yolk sac tumor

  • malignant
  • AFP positive
30
Q

signet cell adenocarcinoma

A

kruckenburg tumor

- malignant

31
Q

Call-exner bodies

A

granulosa cell tumor
- malignant

Call-exner bodies resembles follicle

32
Q

Coffee bean nuclei on H&E stain

A

Brenner tumor

- benign

33
Q

Meigs syndrome

  • what is it
  • which tumor
A

Triad of:

  1. ovarian fibroma
  2. ascited
  3. hydrothorax

Seen in Fibromas (benign ovarian neoplasm): pulling sensation due to bundles of spindle shaped fibroblasts

34
Q

Psammoma bodies

A

serous cystadenocarcinoma

35
Q

Primary vs metastatic ovarian neoplasm

A

Primary:

  1. unilateral
  2. no surface growth
  3. absence of nodularity
  4. larger >10cm

Metastatic

  1. bilateral
  2. surface+hilar involvement
  3. Nodular growth
  4. Infiltrative growth
  5. Smaller
36
Q

Metastatic gastric GI carcinoma that met to ovaries + buzz word

A

Krukenberg tumor

- signet cell

37
Q

Origin of pseudomyxoma peritoneii

A

Jelly belly!
- mucin throughout abdomen

appendiceal origin

38
Q

Psammoma bodies are seen in which cancers

A
  1. endometrialcarcinoma
  2. papillary thyroid carcinoma
  3. meningioma
  4. mesothelioma

Unit 1 ID+LC (32 decks)

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