Pathology of Lung Cancers Flashcards
1
Q
What compounds are in tobacco smoke?
A
polycyclic hydrocarbons aromatic amines phenols nickel cyanates
2
Q
Name the 4 most common lung cancers - commonest - rarest?
A
- adenocarcinoma (35%)
- squamous carcinoma (30%)
- small cell carcinoma (25%)
- large cell carcinoma (10%)
3
Q
What is the most common survival time for the 4 cancers? Shortest to longest?
A
Small Cell
Large Cell
Squamous + Adenocarcinoma
4
Q
What gene mutation is commonly seen in adenocarcinomas and what is its treatment?
A
EGFR gene
tyrosine kinase inhibitors (erlotinib)
5
Q
Name another oncogene that can be treated by a drug?
A
EML4-ALK fusion oncogene
drug treatment: crizotinib
