Pathology of Liver

Question 1

acute hepatitis

Answer 1

causes: viral, drug- induced, autoimmune or seronegative (no cause)
infection agents: Hep A/B/C/E, herpes, leptospires
hepatitis = inflammation

Question 2

fulminant hepatitis

Answer 2

will quickly lead to acute liver failure
often caused by viral hepatitis
otherwise caused by drugs and toxins
jaundice, mental status changes, liver necrosis

Question 3

hepatitis

Answer 3

necrosis spreads between central veins and portal tracts of hepatosites
caused by: Hep B,C,D, autoimmune hepatitis, drug-induced hepatitis

Question 4

chronic fibrosis

Answer 4

liver feels firm due to fibrosis
portal inflammation, interface hepatitis, lobular inflammation, fibrosis

Question 5

fatty liver disease (steatosis)

Answer 5

reversible with anstinence, enlarged, yellow, greasy liver, can progress to fibrosis around central vein

Question 6

alcohol liver disease

Answer 6

alcohol metabolism generates NADH which breaks down fatty acids and forms triglycerides which leads to steatosis
excessive stress from this can lead to heaptocyte injury and necro-inflammatory activity which causes liver fibrosis