Pathology Findings Flashcards
Findings in Coeliac disease?
Crypt hyperplasia with inflammatory cells in the mucosa
Total or subtotal villous atrophy
Findings in Barrett’s oesophagus?
Metaplasia of lower oesophageal epithelium to gastric- or intestinal-type epithelium
Findings in Crohn’s disease?
Macroscopic: skip lesions, cobblestone appearance, fissured ulcers
Microscopic: thickened wall, transmural inflammation, granulomas
Findings in Ulcerative Colitis?
Mucosal/submucosal inflammation only, crypt abscesses, superficial ulceration
Findings in Chronic Cholecystitis?
Chronic inflammatory changes
Rokitansky-Aschoff sinuses
Findings in acute viral hepatitis?
Swelling of hepatocytes with spotty necrosis
Councilman bodies
Findings in alcoholic hepatitis?
Fatty accumulation in cytoplasmic vacuoles, necrosis, Mallory hyaline material
Findings in chronic active hepatitis?
Piecemeal necrosis
Findings in autoimmune hepatitis?
Interface hepatitis, portal plasma cell infiltration
Findings in haemochromatosis?
Excessive hepatic iron visible as Blue on Perl’s stain
Findings in primary biliary cirrhosis?
Portal hepatitis, granulomatous destruction of bile ducts.
Later: periportal hepatitis and bile duct proliferation.
Findings in liver cirrhosis?
Macroscopic: macro-/micronodular
Microscopic: fibrous tissue visible as red on von Gieson stain
Findings in diffuse alveolar damage?
Alveolar hyaline membranes, thickened alveolar walls
Findings in previous asbestos exposure?
Asbestos bodies
Findings in pulmonary fibrosis?
Proliferation of Type II pneumocytes, thickening of alveolar walls
Finding on renal biopsy in malignant hypertension?
Renal arteriolar fibrinoid necrosis
Findings on renal biopsy in diabetic glomerulosclerosis?
Kimmelstein-Wilson nodules, thickened capillary basement membranes, hyalinisation of arterioles
Findings in Hosgkin’s Disease?
Reed-Sternberg cells, abnormal lymph node architecture
Nodular sclerosing type has fibrous tissue
Findings in myelofibrosis?
Bone marrow fibrosis 2ry to fibroblast proliferation
Findings in Multiple Myeloma?
Plasma cell proliferation in bone marrow
Findings on temporal artery biopsy in temporal arteritis?
May be normal
May have plasma cells, lymphocytes and multinucleate giant cells
Findings in Polymyositis?
Muscle fibre necrosis
Lymphocyte infiltration
Findings in acromegaly?
Pituitary acidophil macroadenomas (somatotroph adenomas)
Findings in hyperprolactinaemia?
Pituitary chromophobe adenomas
