Pathology and Histology

Question 1

Chromogranin a sign of…

Answer 1

Neuroendocrine

Question 2

Stain looking for fat

Answer 2

Sudan red

Question 3

Stain for fungi

Answer 3

Silver stain, GMS

Question 4

Pathology of Asthma

Answer 4

Smooth muscle hypertrophy
Inflammation in walls
mucous impaction

Charlot leyden - look like splinters, related to eos
Curshmann’s spirals - look like ebola

Question 5

What should you think about if you see big pink cells?

Answer 5

Granulomas

Question 6

Warthin-Starry Stain

Answer 6

Legionella

Question 7

Dieterle Stain

Answer 7

Legionella

Question 8

Toxo on path

Answer 8

spotted leopard foot ball

Question 9

CMV on path

Answer 9

Owl eyes or alien faces

Question 10

HMB45+ association

Answer 10

LAM

Question 11

Marker of LAM

Answer 11

HMB45+ and spindle cells

Question 12

Pathology of PAH

Answer 12

Plexiform lesion - vascular lesions with proliferated blood channels

Concentric intimal obliteration of pulmonary vessels

Question 13

Alveolar Macrophages filling the alveoli

Answer 13

Desquamative interstitial pneumonia

Question 14

Bronchiolitis obliterans

Answer 14

Massan body - rounded balls of fibroblasts in the alveoli with normal alveoli walls

Question 15

Massan Body

Answer 15

Bronchiolitis obliterans
COP

Question 16

Langerhans markers

Answer 16

S-100
CD1a

Burbeck granules
Coffee bean looking cells

Question 17

PSA stain

Answer 17

Aveolar proteinosis

Question 18

Pathology with transplant rejection

Answer 18

Lymphocytic perivascular infiltrate (acute)

Broncholitis obliterans (CLAD)

Question 19

Pathology of squamous cell cancer

Answer 19

Keritin pearls
intracellular bridging

Question 20

Pathology of crypto

Answer 20

mucicamine stain
Halo on silver stain
capsular

Question 21

Path of adenocarcinoma

Answer 21

glandular

Question 22

Path of cocci

Answer 22

spherule containing endospores

Question 23

Answer 23

Feraginous body

Looks like shower curtain rod

Question 24

S-100 and CD1a +

Answer 24

Pulmonary Langerhans Histiocytosis

Question 25

Histology of mesothelioma

Answer 25

CK5/6 Calretinin Wilma tumor antigen

Question 26

HMB-45

Answer 26

LAM

Question 27

PAS+ and GM-CSF ab

Answer 27

PAP

Question 28

Markers of Squamous cell cancer

Answer 28

CK 5/6 p63 May produce PTHrP

Question 29

Markers of Small Cell Cancer

Answer 29

Chromo Synapto CD-56 TTF-1

Question 30

Path of Small cell

Answer 30

poorly differentiated small cells with big nuclei Arise from neuroendocrine cells

Question 31

Paraneoplastic syndrome associated with small cell

Answer 31

Eaton Lambert - production ADH or ACTH

Question 32

Markers of adenocarcinoma

Answer 32

CK-7 TTF-1 + CK20 Appear glandular

Question 33

Markers of Large Cell

Answer 33

CK- 7 No CK20

Question 34

Calretinin and Wilms tumor antigen

Answer 34

Mesothelioma

Question 35

Path of sarcoid

Answer 35

well formed, coalescing granulomas, with histiocytes and multinucleated giant Cells. Look for location of the granulomas, remember sarcoid tracks along bronchovascular bundle

Question 36

Path of PJP

Answer 36

Silver stain Dented ping pong balls Small No budding Alveoli filled with foamy exudate

Question 37

Necrotizing Caseating granulomas budding sesame seed small organisms on silver stain

Answer 37

Histoplasmosis

Question 38

Purplish/Bluish “waves”, seem to be localized around blood vessels

Answer 38

Aspergillus

Question 39

Broad based, branching hyphae no septations ribbon like

Answer 39

mucormycosis

Question 40

Broad based budding with double refractile cell wall

Answer 40

Blasto

Question 41

Nests of cells with visible nucleoli, salt and pepper appearance Vascular congestion

Answer 41

Carcinoid

Question 42

Dust laden macrophages with adjacent granulomatous reaction Birefringent talc

Answer 42

Silicotic Nodule

Question 43

RBCs in the alveolar spaces and hemosiderin laden macrophages in the alveoli space

Answer 43

Good pastures (also consider other causes of hemorrhage - look for vasculitis)

Question 44

alveoli filled w. foamy pink exudate, hyperplasia of type II alveolar lining cells. The interstitium contains a mild chronic inflammatory cell infiltrate.

Answer 44

PJP

Question 45

Answer 45

Bacterial Pneumonia

Question 46

Answer 46

Sarcoid

Question 47

Answer 47

PJP

Question 48

Answer 48

PJP

Question 49

Answer 49

Aspergillus

Question 50

Answer 50

Aspergillus

Question 51

Answer 51

Squamous cell Keritin pearls

Question 52

Answer 52

Small Cell Carcinoma

Question 53

Answer 53

Carcinoid

Question 54

Answer 54

UIP patchy interstitial fibrosis that appears more severe in the subpleural regions Increased macs in air space SM metaplasia prominant mucostasis

Question 55

Answer 55

UIP patchy interstitial fibrosis that appears more severe in the subpleural regions Increased macs in air space SM metaplasia prominant mucostasis

Question 56

Answer 56

PAH presence of atherosclerosis in the large elastic pulmonary artery. Its thickened intima contains a proliferation of fibroblasts and there are numerous foamy macrophages

Question 57

Answer 57

PAH vessels exhibit hypertrophy of the media with intimal thickening and fibrosis. growth of muscle into the walls of pulmonary arterioles (normally very thin-walled structures)

Question 58

Answer 58

Adeno

Question 59

Answer 59

Cocci - spherules containing endospores

Question 60

Answer 60

Cryptogenic Organizing Pneumonitis pale bluish rounded masses of fibroblastic proliferation. Polypoid granulation tissue in bronchioles

Question 61

Answer 61

Toxo

Question 62

Answer 62

Blasto

Question 63

Dieterle stain

Answer 63

Legionnaires' disease

Question 64

Answer 64

Broncholitis Obliterans in transplant complete fibrous obliteration of airways Chronic bronchiolitis Elastic tissue stain to look at scars

Question 65

Answer 65

broad, thin-walled, nonseptate hyphae with irregular branching at right angles Pulmonary mucormycosis Ribbions