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ABIM Pulmonary Boards > Pathology and Histology > Flashcards

Pathology and Histology Flashcards

1
Q

Chromogranin a sign of…

A

Neuroendocrine

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2
Q

Stain looking for fat

A

Sudan red

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3
Q

Stain for fungi

A

Silver stain, GMS

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4
Q

Pathology of Asthma

A

Smooth muscle hypertrophy
Inflammation in walls
mucous impaction

Charlot leyden - look like splinters, related to eos
Curshmann’s spirals - look like ebola

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5
Q

What should you think about if you see big pink cells?

A

Granulomas

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6
Q

Warthin-Starry Stain

A

Legionella

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7
Q

Dieterle Stain

A

Legionella

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8
Q

Toxo on path

A

spotted leopard foot ball

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9
Q

CMV on path

A

Owl eyes or alien faces

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10
Q

HMB45+ association

A

LAM

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11
Q

Marker of LAM

A

HMB45+ and spindle cells

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12
Q

Pathology of PAH

A

Plexiform lesion - vascular lesions with proliferated blood channels

Concentric intimal obliteration of pulmonary vessels

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13
Q

Alveolar Macrophages filling the alveoli

A

Desquamative interstitial pneumonia

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14
Q

Bronchiolitis obliterans

A

Massan body - rounded balls of fibroblasts in the alveoli with normal alveoli walls

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15
Q

Massan Body

A

Bronchiolitis obliterans
COP

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16
Q

Langerhans markers

A

S-100
CD1a

Burbeck granules
Coffee bean looking cells

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17
Q

PSA stain

A

Aveolar proteinosis

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18
Q

Pathology with transplant rejection

A

Lymphocytic perivascular infiltrate (acute)

Broncholitis obliterans (CLAD)

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19
Q

Pathology of squamous cell cancer

A

Keritin pearls
intracellular bridging

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20
Q

Pathology of crypto

A

mucicamine stain
Halo on silver stain
capsular

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21
Q

Path of adenocarcinoma

A

glandular

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22
Q

Path of cocci

A

spherule containing endospores

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23
Q
A

Feraginous body

Looks like shower curtain rod

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24
Q

S-100 and CD1a +

A

Pulmonary Langerhans Histiocytosis

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25
Q

Histology of mesothelioma

A

CK5/6
Calretinin
Wilma tumor antigen

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26
Q

HMB-45

A

LAM

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27
Q

PAS+ and GM-CSF ab

28
Q

Markers of Squamous cell cancer

A

CK 5/6
p63

May produce PTHrP

29
Q

Markers of Small Cell Cancer

A

Chromo
Synapto
CD-56
TTF-1

30
Q

Path of Small cell

A

poorly differentiated small cells with big nuclei
Arise from neuroendocrine cells

31
Q

Paraneoplastic syndrome associated with small cell

A

Eaton Lambert - production ADH or ACTH

32
Q

Markers of adenocarcinoma

A

CK-7
TTF-1

+ CK20

Appear glandular

33
Q

Markers of Large Cell

A

CK- 7

No CK20

34
Q

Calretinin and Wilms tumor antigen

A

Mesothelioma

35
Q

Path of sarcoid

A

well formed, coalescing granulomas, with histiocytes and multinucleated giant
Cells. Look for location of the granulomas, remember sarcoid tracks along bronchovascular bundle

36
Q

Path of PJP

A

Silver stain

Dented ping pong balls
Small
No budding
Alveoli filled with foamy exudate

37
Q

Necrotizing Caseating granulomas
budding
sesame seed small organisms on silver stain

A

Histoplasmosis

38
Q

Purplish/Bluish “waves”, seem to be localized around blood vessels

A

Aspergillus

39
Q

Broad based, branching hyphae no septations
ribbon like

A

mucormycosis

40
Q

Broad based budding with double refractile cell wall

41
Q

Nests of cells with visible nucleoli, salt and pepper appearance
Vascular congestion

42
Q

Dust laden macrophages with adjacent granulomatous reaction
Birefringent talc

A

Silicotic Nodule

43
Q

RBCs in the alveolar spaces and hemosiderin laden macrophages in the alveoli space

A

Good pastures (also consider other causes of hemorrhage - look for vasculitis)

44
Q

alveoli filled w. foamy pink exudate, hyperplasia of type II alveolar lining cells. The interstitium contains a mild chronic inflammatory cell infiltrate.

45
Q
A

Bacterial Pneumonia

46
Q
49
Q
A

Aspergillus

50
Q
A

Aspergillus

51
Q
A

Squamous cell
Keritin pearls

52
Q
A

Small Cell Carcinoma

53
Q
54
Q
A

UIP

patchy interstitial fibrosis that appears more severe in the subpleural regions
Increased macs in air space
SM metaplasia
prominant mucostasis

55
Q
A

UIP

patchy interstitial fibrosis that appears more severe in the subpleural regions
Increased macs in air space
SM metaplasia
prominant mucostasis

56
Q
A

PAH
presence of atherosclerosis in the large elastic pulmonary artery. Its thickened intima contains a proliferation of fibroblasts and there are numerous foamy macrophages

57
Q
A

PAH
vessels exhibit hypertrophy of the media with intimal thickening and fibrosis.
growth of muscle into the walls of pulmonary arterioles (normally very thin-walled structures)

58
Q
59
Q
A

Cocci - spherules containing endospores

60
Q
A

Cryptogenic Organizing Pneumonitis

pale bluish rounded masses of fibroblastic proliferation.
Polypoid granulation tissue in bronchioles

62
Q
63
Q

Dieterle stain

A

Legionnaires’ disease

64
Q
A

Broncholitis Obliterans in transplant

complete fibrous obliteration of airways
Chronic bronchiolitis
Elastic tissue stain to look at scars

65
Q
A

broad, thin-walled, nonseptate hyphae with irregular branching at right angles

Pulmonary mucormycosis

Ribbions

ABIM Pulmonary Boards (11 decks)

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