Neoplasm

Question 1

NSCLC Stage 1 treatment

Answer 1

Surgery or if inoperable SBRT

> 1a -> post op targeted therapy if +EGFR
OR
if EGFR- neoadjuvant chemo then surgery

Question 2

NSCLC Stage 2 treatment

Answer 2

Surgery with adjuvant chemo
OR
EGFR+/ALK+ then targeted therapy
OR
If EGFR/ALK neg then neoadjuvant chemo + immunotherapy then surgery

Question 3

NSCLC Stage 3 Treatment

Answer 3

Chemo + radiation + adjuvant immunotherapy or targeted therapy

If EGFR+ then adjuvant osimertinib
Or
High PDL1–> immunotherapy
Or
if EGFR neg then neoadj chemo, immuno then surgeryN

Question 4

NSCLC Stage 4 or recurrent

Answer 4

Chemo
Targeted therapy (EGFR- erlotinib, ALK alectinib)
Immunotherapy
Supportive Care

Question 5

Treatment for Pancoast tumor

Answer 5

Induction chemoradiotherapy
- if resectable better if chemo/rad pre op
- If not or N2 then concurrent chem/rad

Question 6

NSCLC surveillance

Answer 6

CT every 6mo for 2 years
THEN yearly until 5 years
(if eligible for LDCT then yearly)

Question 7

Treatment for Extensive Small cell

Answer 7

Cisplatin + VP-16 (epoposide)
OR carboplatin + VP-16 (less toxic)
OR cisplatin + irinotecan

2 cycles for induction then:
- 2-4 more for consolidaation
- No benefit to >6 cycles

Can add immunotherapy

NO XRT survival benefit but can be palliative

Question 8

Treatment for limited small cell

Answer 8

XRT + treatment for extensive