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High Yield Stuff > Pathology > Flashcards

Pathology Flashcards

1
Q

Male cancer incidence

A

Prostate
Lung
Colon

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2
Q

Female cancer incidence

A

Breast
Lung
Colon

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3
Q

Male cancer mortality

A

Lung
Prostate
Colon

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4
Q

Female cancer mortality

A

Lung
Breast
Colon

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5
Q

Skin cancer types by frequency

A

Basal > squamous > melanoma

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6
Q

Acanthosis nigricans a/w

A

Gastric adenocarcinoma
Obesity
Insulin resistance

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7
Q

Leser-Trelat sign a/w

A

GI adenocarcinoma

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8
Q

Trousseau sign is migratory superficial thrombophlebitis a/w

A

Adenocarcinoma, pancreatic

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9
Q

Lambert Eaton
A/w
Antibodies against

A

Small cell lung cancer

Presynaptic P/Q type calcium channels at NMJ

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10
Q

Myasthenia gravis
A/w
Antibodies against

A

Thymoma

Postsynaptic AChR at NMJ

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11
Q

Haematogenous spread of sarcomas and 4 carcinomas

A

HCC
Renal cell
Follicular thyroid
Choriocarcinoma

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12
Q

Mets to brain from

A 
Lung
Breast
Prostate
Melanoma
GI
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13
Q

Mets to liver

A

Colon
Stomach
Pancreas

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14
Q

Mets to bone

A

Prostate breast

Lung thyroid kidneys

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15
Q

ALP

A

Mets to bone or liver
Paget disease of bone
Seminoma

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16
Q

aFP

A

HCC
hepatoblastoma
Yolk sac
Mixed germ cell

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17
Q

B-hCG

A

Hydatiform moles
Choriocarcinoma
Testicular cancer
Mixed germ cell tumour

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18
Q

CA 15-3/27-29

A

Breast cancer

19
Q

CA19-9

A

Pancreatic adenocarcinoma

20
Q

CA125

A

Ovarian cancer

21
Q

Calcitonin

A

Medullary thyroid cancer

22
Q

CEA

A 
Colorectal 
Pancreatic 
Gastric
Breast
Medullary thyroid
23
Q

Psammoma bodies in PSMM

A

Papillary thyroid
Serous cyst adenocarcinoma ovary
Meningioma
Malignant mesothelioma

24
Q

Carbon tetrachloride

A

Centrilobular necrosis

Fatty change

25
Q

Asbestos

A

Bronchogenic ca

Mesothelioma

26
Q

Aflatoxins from aspergillus

A

HCC

27
Q

WT1/WT2

A

Wilms tumour

28
Q

VHL inhibits

A

Hypoxia inducible factor 1a

29
Q

P53 activates p21 and blocks G1-S phase.

What other TSG blocks this phase?

A

Rb, inhibits E2F

30
Q

PTEN TSG

A

Breast
Prostate
Endometrial cancer

31
Q

NF2 product

A

Merlin schwannomin protein

32
Q

NF1

A

Ras GTPase activating protein / neurofibromin

33
Q

DCC TSG

A

Colon cancer

34
Q

CDKN2A TSG

A

Melanoma

Pancreatic cancer

35
Q

ALK

A

Receptor tyrosine kinase

Lung adenocarcinoma

36
Q

BCR-ABL

A

Tyrosine kinase

CML ALL

37
Q

BCL-2

A

Anti apoptosis

Follicular and diffuse large B cell lymphoma

38
Q

BRAF

A

Serine/threonine kinase

Melanoma
Nonhodgkin lymphoma

39
Q

c-KIT

A

Cytokine receptor

GIST

40
Q

c-MYC

A

Transcription factor

Burkitt lymphoma

41
Q

HER2

A

Tyrosine kinase

Breast
Gastric

42
Q

JAK2

A

Tyrosine kinase

Chronic myeloproliferative disorders

43
Q

KRAS

A

GTPase

Colon
Lung
Pancreatic

44
Q

MYCL1 and MYCN are transcription factors in Lung and Neuroblastoma.

What cancers is the tyrosine kinase oncogene RET a/w?

A

MEN 2A, 2B

Medullary thyroid

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