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Immunology Flashcards

1
Q

Celiac nodes

A 
Liver
Stomach
Spleen
Pancreas
Upper duodenum
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2
Q

Superior mesenteric

A

Lower duodenum
Jejenum
Ileum
Colon to splenic flexure

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3
Q

Inferior mesenteric

A

Colon from splenic flexure to upper rectum

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4
Q

Internal iliac

A 
Lower rectum to above pectinate line of anal canal
Bladder
Vagina middle third
Cervix
Prostate
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5
Q

Para aortic

A

Tested
Ovaries
Kidneys
Uterus

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6
Q

Superficial inguinal

A

Anal canal below pectinate line
Skin below umbilicus except popliteal
Scrotum
Vulva

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7
Q

Popliteal

A

Dorsolateral foot

Post calf

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8
Q

R lymphatic duct drains

A

R side of body above diaphragm

Thoracic duct drains everything else into junction of l subclavian and internal jugular veins

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9
Q

Encapsulated organisms

Please SHINE my SKiS

A 
Pseudomonas 
Strep pneumonia 
H Influenza
Neisseria meningitis 
E. coli
Salmonella 
Klebsiella
Group B Strep
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10
Q

Post splenectomy on blood smear

A

Howell Jolly bodies
Target cells
Thrombocytosis
Lymphocytosis

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11
Q

HLA A3

A

Haemochromatosis

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12
Q

HLA B8

A

Addison disease

MG

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13
Q

HLA B27

A

PAIR

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14
Q

HLA DQ2/8

A

Celiac disease

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15
Q

HLA DR2

A

MS
SLE
hay fever
Goodpastures

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16
Q

HLA DR3

A 
DM1
SLE 
Graves
Hashimotos
Addison
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17
Q

HLA DR4

A

RA
DM1
Addison disease

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18
Q

HLA DR5

A

Pernicious anaemia B12 def

Hashimotos

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19
Q

T cell activation

A

Signal 1
MHC 2 APC recognised by TCR on CD4 cells. Antigen presented on MHC 1 to CD8 cells

Signal 2
Costim B7 (Cd80/86) and CD28
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20
Q

B cell activation

A

Antigen on MHC 2 recognised by Th cell.

CD40 receptor on B cell binds with CD40L on Th cell

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21
Q

Naive B cells express

22
Q

IgG

A

Delayed response
MC in serum
Crosses placenta

23
Q

IgA

A

GIT Peyer patches
Most produced AB
Secretions and breast milk

24
Q

IgM

A

Immediate
Monomer on B cell
Pentamer with J chain

25
Q

IgE

A

Type 1 HS
Histamine
Eosinophils

26
Q

Cytokines secreted from macrophages

A 
IL 1
IL 6
IL 8
IL 12
TNFa
27
Q

Cytokines secreted from all T cells

28
Q

Cytokines secreted from Th1 cells

29
Q

Cytokines secreted from Th2 cells

A

IL4
IL5
IL10

30
Q

Hot T bone stEAK

A 
IL 1 fever = hot
IL2 stimulates T cells
IL3 stimulates bone marrow
IL4 stimulates IgE production 
IL5 stimulates IgA production 
IL6 stimulates aKute phase protein production
31
Q

IL 8

Clean up on aisle 8

A

Neutrophils recruited to clear infections

32
Q

IL 12

A

T cells —> Th1 cells

Activate NK cells

33
Q

TNFa

A

Septic shock
Activates endothelium
Causes WBC recruitment vascular leak
Cachexia

34
Q

IFNy

A

Macrophages —> IL 12 —> NK and T cells —> IFNy —>macrophages to kill phagocytosis pathogens

35
Q

IL 10 and TGF-B

A

atTenuate/ regulate immune system

36
Q

MHC 1 on all nucleated cells but not

A

Mature RBCs

37
Q

TCR
CD3
CD28
CXCR4 / CCR5

38
Q

CD4

CD40L

A

Helper T cells

39
Q

CD8
CXCR4
CCR5

A

Cytotoxic T cells

40
Q

CD4

CD25

A

Regulatory T cells

41
Q

Ig
CD19/ 20/ 21 (EBV) / 40
MHC 2
B7

42
Q 
CD14
CD40
CCR5
MHC II
B7 (CD80/86)
Fc and C3b receptors
A

Macrophages

43
Q

CD16 binds F.C. of IgG

CD56

44
Q

CD34

A

Hematopoietic stem cells

45
Q

Superantigens = S pyogenes/ aureus

Endotoxins/LPS =?

46
Q

Antigenic variation

A

Bacteria Salmonella Borrelia recurrentis

Influenza HIV HCV

Trypanosomes

47
Q

Passive immunisation

A 
Tetanus toxin
Botulinum toxin
HBV
Varicella 
Rabies

Give antibodies to unvaccinated after exposure

48
Q

Live attenuated vaccine

A 
BCG
Influenza 
Measles
Mumps
Polio
Rubella
Varicella 
Yellow fever
49
Q

Inactivated or killed vaccine

A

Rabies
Influenza injections
Polio Salk
Hepatitis A

50
Q

HS types

A

ACID

Anaphylactic and Atopic
Cytotoxic AB mediated
Immune complex
Delayed cell mediated

High Yield Stuff (10 decks)

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