Pathology Flashcards
Why male patient with atherosclerosis, intermittent claudication, could have sexual dysfunction?
Aortoiliac atherosclerosis ▶️ ⬇️ blood flow to internal pudendal branches of internal iliac ▶️ hard sustain erection
Medium-sized arteries with calcification of internal elastic lamina and media, NOT obstruct blood flow, NOT involve intima. Disease and finding in x-ray.
Mönckeberg sclerosis
“Pipestem appearance”
Complication of septic abortion
Asherman’s syndrome ▶️ synechiae (adhesions) in uterine cavity ▶️ secondary amenorrhea and infertility
Principal site in kidney where uric acid precipitate. Why?
Distal tubules and collecting ducts
Segments with more acidic environment ▶️ uric acid crystals precipitate in acid pH.
How could the chemotherapy for a high grade lymphoma, leukemia or other rapid-cell turnover tumor lead in obstructive uropathy and renal failure?
Tumor lysis syndrome ▶️ ⬆️ uric acid ▶️ precipitate in uric acid crystals
Achalasia associate with which type of cancer? Secondary causes of achalasia.
- Esophageal cancer ▶️ squamous cell carcinoma
- Secondary ▶️ chagas disease (T. cruzi), extraesophageal malignancies (mass effect or paraneoplastic)
What suggest an increase in acetylcholinesterase level in amniotic fluid in 25th week of pregnancy? What other marker you can find?
- Neural tube defects ▶️ failure of fusion in week 4th
- ⬆️ alfa-fetoprotein (also elevated in maternal plasma because crosess the placenta)
Posterior neural tube defects. In which of them the alfa-fetoprotein is normal?
Spina bifida oculta (AFP normal), meningocele, myelomeningocele
Hirschsprung’s disease is an example of which fetal abnormality?
Migration abnormality ▶️ failure neural crest cells to migrate to intestinal wall
Duodenal atresia is an example of which fetal abnormality?
Abnormal apoptosis ▶️ duodenal lumen fails to recanalize at 8-10 weeks of gestation
How is the Retinoblastoma protein phosphorylated and its function?
- Growth factors ▶️ (+) cyclin D, cyclin E, CDK (cyclin kinases) 4, 8
- G1-S progression ▶️ ⬆️ dihydrofolate reductase, DNA polymerase ▶️ enzymes for the S phase (DNA synthesis)
Function of p27, levels on normal and tumoral tissue
- Cell cycle inhibitor ▶️ (-) cyclin-dependent kinases ▶️ arrest cell in G1
- Normal tissue - high levels
- Tumoral tissue - low levels
When do you use an inferior vena cava filter?
Prevent progression of DVT from legs to lungs vasculature when anticoagulation is contraindicated
Test for diagnose zollinger-ellison syndrome. Association with which syndrome?
- Positive secretin stimulation test: gastrin remain ⬆️ after secretin administration (normally ⬇️ gastrin release)
- MEN 1
Why do zollinger-ellison patients have diarrhea?
Malabsorption ▶️ pancreatic/intestinal enzymes inactivated by gastric acid
Location and clinical manifestation of VIPoma.
Neuroendocrine tumor of pancreas ▶️ ⬆️ Vasoactive intestinal polypeptide ▶️ diarrhea persist with fasting, achlorhydria, hypokalemia
Histologic finding of Krukenberg tumor. What is this tumor?
- Signet ring cells - mucin producers ▶️ large amount of mucin displacing the nucleus
- Metastatic tumor in ovaries from diffuse gastric carcinoma (linitis plastica) or breast cancer
Triad of renal cell carcinoma. Histologic finding. What is the most common presentation?
- Hematuria, flank pain, palpable abdominal mass (minority patients <10%)
- Most common presentation→Non-specific symptoms (fever, weight-loss, anorexia, etc) and paraneoplastic syndromes (ex, polycythemia - ↑EPO; hypercalcemia - ↑PTH)
- Lungs most common metastases
- Nests of (proximal tubular) epithelial cells (rounded, polygonal) with abundant clear cytoplasm→↑glycogen and lipids
FRAGMENT CARD!
*Most common renal malignancy→clear cell carcinoma
Virtual pathognomonic finding of cystic fibrosis and its consequence. Why does it happen?
- Congenital bilateral agenesia of vas deferens (CBAVD)▶️ Azoospermia (unable secrete semen) ▶️ infertility (🚫 sperm transport, normal spermatogenesis)
- CFTR mutation ▶️ abnormal development wolffian structures
Diagnosis of cystic fibrosis.
- ⬆️ Chloride levels in sweat ▶️ Cl channel in sweat glands can not reabsorb the Cl
- Abnormal nasal transepithelial potential difference
- Genetic testing→defect CFRT gene on chromosome 7, deletion Phe508
Why can the gastroesophageal reflux disease (GERD) course with dysphagia?
Impaired peristalsis, esophageal inflammation, stricture or malignancy
How parvovirus B19 infects? Which cells?
RBC precursors in bone marrow ▶️ group P antigen (globoside) ▶️ receptor for B19
Acute and chronic sequelae of parvovirus B19 infection, who are most affected?
- Chronic anemia ▶️ immunosupressed
- Aplastic crisis ▶️ underlying hematologic abnormality (sickle cell disease)
Most common malignancies associated with asbestos exposure.
Bronchogenic carcinoma>Malignant mesothelioma
What can explain new-onset odynophagia in context of chronic GERD disease?
Erosive esophagitis ▶️ ulcer formation
Which coagulation factor is tested by prothrombin time and no by activated partial thromboplastin time?
*PT ⬆️ and PTT normal
Factor VII (extrinsic pathway), also XIII.
*When do you think in factor VII deficiency?
Most common congenital heart disease in Turner syndrome
Bicuspid aortic valve disease (20-30%)
*Coarctation of the aorta (3-10%), aortic root dilation with ↑risk of aortic dissection in adulthood
Most common cardiac anomaly of Down Syndrome
Complete atrioventricular canal ▶️ atrial septal defect + ventricular septal defect
Common cardiac anomaly in marfan and ehlers-danlos syndrome and clinical finding.
Mitral valve prolapse
Mid-systolic click, late systolic murmur
In which cells there is an increase of what aminoacid during hepatic encephalopathy? Why is it accumulated?
Hyperammonemia
- NH3 taken by astrocytes ▶️ ⬆️ NH3 + glutamate ▶️ ⬆️ glutamine ▶️ ⬆️ intracellular osmolarity ▶️ swelling ▶️ ❌ glutamine release ▶️ no glutamine in neurons to make glutamate ▶️ 🚫 of excitatory neurotransmission.
Which compounds are major contributors to the progression of insulin resistance? How does it happen?
Insulin resistance ▶️ in adipose tissue ▶️ no antilipolytic effect ▶️ lipolysis:
Chronically ⬆️ fatty acids ▶️ ❌ insulin-dependent glucose uptake, ⬆️ hepatic gluconeogenesis
Ultrastructural change that suggest irreversible ischemic myocardial cell injury.
Mitochondrial vacuolization ▶️ unable to produce ATP
*Simple swelling ▶️ reversible cell injury
Cause of Duchenne dystrophy and what leads that fact? Why can you find elevated creatin kinase? Important sign.
- Frameshift or nonsense mutation of dystrophin gene on X chromosome p21 ▶️ truncated protein ▶️ myonecrosis
- Dystrophin prevents degradation of glycoproteins complexes at plasma membrane ▶️ if 🚫 ▶️ breakdown of glycoproteins and membrane ▶️ muscle fiber degeneration
- Gower’s sign
Pathology finding in a Duchenne muscle dystrophy, to what sign agree?
Fibrofatty (fat and connective tissue) muscle replacement ▶️ pseudohypertrophy (common calf muscles)
Cause of humoral hypercalcemia of malignancy and mechanism. Most common tumors associated.
- Secretion of Parathyroid hormone-related protein (PTHrP) ▶️ ⬆️ bone resorption ⬇️ renal excretion of Calcium ⏩ Hypercalcemia with NO focal lytic lesions.
- Tumors secreting: squamous cell tumors (lung, neck, esophagus), renal, bladder, ovarian, breast, etc.
*PTH levels low - hypercalcemia suppression feedback
Causes and regions of watershed infarcts in the brain. How do they look in gross specimen?
- Cardiogenic shock ▶️ profound hypotension ▶️ hypoxic-ischemic encephalopathy
- Areas supplied by most distal branches of cerebral arteries ▶️ Border between areas perfused by ACA, MCA, PCA
- Bilateral wedge-shaped strips of necrosis adjacent to the longitudinal cerebral fissure
Most probably histologic finding in women with blood discharge from the right nipple, no pain no masses or skin changes.
Intraductal papilloma (most common cause of alarming nipple discharge) ▶️ proliferation of papillary cells in a duct or cyst wall, with fibrovascular core ▶️ twist of vascular stalk ▶️ bleed
*may contain foci of atypia or ductal carcinoma in situ
Conditions that increase the risk of pigment gallstones. Why does it occur?
- ⬆️ unconjugated bilirrubin ▶️ ⬆️ calcium bilirrubinate precipitation
- Black stones ▶️ chronic hemolysis (sickle cell disease, B-thalasemia, spherocytosis), ⬆️ enterohepatic cycling of bilirrubin (ileal disease)
- Brown stones ▶️ biliary tract infection (E. coli, liver fluke [Clonorchis sinensis]) ▶️ ⬆️ B-glucuronidase (release from injured hepatocytes and bacteria)
What allow distinguish silicosis of other pneumoconioses? Exposure associated.
- Calcification of the rim of hilar nodes ▶️ eggshell calcification (chest x-ray)
- Birefringent silica particles surrounded by fibrous tissue [dense collagen fibers (histology polarized microscopy)
- Foundries, sandblasting, mines
Most common malignant hepatic lesion. Why?
- Metastatic liver disease from another primary site (breast, lung, colon) ▶️ 20 times more common than hepatocellular carcinoma
- Large size, dual blood supply, high perfusion rate, filtration function of Kuppfer cells ▶️ 2nd most common site of spread (after lymph nodes)
How do you diagnose erythroblastosis fetalis antenatally?
Amniocentesis ▶️ amniotic fluid bilirrubin levels ▶️ assess fetal hemolysis
How do you diagnose antenatally cystic fibrosis?
Amniocentesis ▶️fetal cells ▶️genetic mutation analysis▶️CFRT gene on chromosome 7, deletion Phe508
How do you diagnose adrenal fetal disorder antenatally? Example.
- Amniocentesis ▶️ 17-hydroxyprogesterone levels, gene linkage analysis (HLA region of chromosome 6), abnormal gene with molecular probes
- Congenital adrenal hyperplasia
Triad of Huntington disease
Movement disorder (Chorea), behavioral abnormalities (depression, apathy, aggressiveness), dementia.
Treatment of Crigler-Najjar syndrome
- Type I ▶️ plasmaferesis and phototherapy
- Type II ▶️ less aggressive ▶️ fenobarbital ▶️ ⬆️ liver enzymes synthesis
Disease which increases unconjugated bilirrubin until certain point that elevates it in brain, and deposits on it, leading in kernicterus. What is the cause?
Crigler-Najjar syndrome ▶️ Uridine Glucuronyltransferase (UGT) deficiency
How do you identify a 11B-hydroxylase deficiency?
- Female virilization
- No cortisol and aldosterone ▶️ precursors diverted toward androgens synthesis; ⬆️ ACTH ▶️ ⬆️ androgens
- Low-renin HTN and hypokalemia: ⬆️ 11-deoxycorticosterone (weak mineralocorticoid)
Why precocious puberty could lead in a shorter stature despite initial growth spurt?
⬆️ sex steroid hormones ▶️ ⬆️ linear growth initially but also closure of long bone epiphyseal plate (“growth plate”)
Hallmarks and red flags that suggest an abusive head trauma in a infant (shaken baby syndrome).
Lethargy, Retinal hemorrhages (highly suggestive), subdural hemorrhages acute or chronic, posterior rib fractures, inconsistency with history or developmental age
When occur the formation of cholesterol gallstones?
Water insoluble cholesterol ▶️ “made” soluble by bile acids (also from cholesterol) and phosphatidylcholine ▶️ when ⬆️ cholesterol>bile acids ⬇️, phosphatidylcholyne ▶️ more cholesterol to make soluble ▶️ precipitates into crystals ▶️ gallstones
Identify by clinic Ehler-danlos syndrome, stage in collagen synthesis that is disrupted.
- Easy bruising, hyperextensible skin, hypermobile joints, poor wound healing
- Procollagen peptidase deficiency ▶️ No proteolytic processing in EC matrix ▶️ no cleavage of disulfide-rich terminal regions of procollagen ▶️ soluble tropocollagen can’t crosslink
What drug do you use to confirm diagnosis of asthma during spirometry, and when do you use it?
Normal spirometry, and history suggest asthma ▶️ methacoline ▶️ muscarinic cholinergic agonist ▶️ bronchoconstriction and ⬆️ mucus production ▶️ broncoprovocation ⏩ ⬇️ FEV1 after mechacoline challenge
Usual findings in a asthma patient spirometry
⬇️ FEV1
⬇️ Peak expiratory flow rate
What is the mechanism and findings of Familial Hypocalciuric Hypercalcemia (FHH)?
- Mutation in CaSR (calcium sensing receptors) = G-protein coupled receptor in renal and parathyroid gland ▶️ sense blood calcium ▶️ control secretion of PTH
- Higher Ca levels required to suppress PTH secretion
- Mild asymptomatic hypercalcemia, ⬇️ excretion urinary calcium (excessive renal Ca reuptake), mildly elevated PTH
What is the use of Sudan III stain for stool? How does it work?
- Most sensitive strategy for screen when suspiction of Generalized malabsorption disorder
- Look for fat (normally unmeasurable) in stool→Fat is the main macronutrient affected in malabsorption
When do you suspect Allergic Bronchopulmonary Aspergillosis (ABPA)? Diagnose.
- History of cyistic fibrosis or asthma (usually corticoid-dependent - 5-10%) + recurrent fleeting infiltratres and Bronchiecatasis.
- ↑IgE, (+) skin test, serum IgG for Aspergillus, eosinophilia
High risk of hematologic malignancy in Down syndrome?
- 10 to 20 fold increase Acute lymphoblastic leukemia
- Acute myelogenous leukemia
What do you see in a karyotype of Chronic myelogenous leukemia? Why does it happen?
- Elongation of chromosome 9
- Reciprocal translocations between the long arms of chromosomes 9 (ABL gene) and 22 (BCR gene) 16►BCR-ABL oncogenic fusion gene on shortened chromosome 22→Philadelphia chromosome
Serum sickness histology finding. Causes and mechanism.
- Fibrinoid necrosis, neutrophils infiltration in small blood vessels ▶️ vasculitis
- Type III hypersensitivity ▶️ deposition IgG and/or IgM - Ag complexes ▶️ activating complement ▶️ consum complement ▶️ ⬇️ C3
- Antigenic heterologous proteins ▶️ chymeric monoclonal antibodies (infliximab, rituximab), non-human proteins (venom antitoxin)
Most common secondary neoplasia in a patient with familial retinoblastoma
Sarcomas (Osteosarcoma most common)
What can result when rapid lysis (chemotherapy) of leukemic cells of Acute myelogenous leukemia (AML) type M3 occur, and why?
Auer Rods in cytoplasm (enzymes that are found in azurophilic granules)→↑ release acid phosphatase, peroxidases, esterases→ (+) Disseminated Intravascular Coagulation (DIC)
Treatment of AML type M3 to improve outcome and prevent initiation of DIC.
All-trans retinoic acid (ATRA)→(+)RARα (retinoic acid alpha receptor)→differentiation in hematopoietic cells→mature neutrophils
Diseases associated with secondary amyloidosis, which type of protein is accumuladted and where?
- Autoimmune diseases or Chronic inflammatory conditions (rheumatoid arthritis, IBD, spondyloarthropathy, familial Mediterranean fever), chronic infection.
- AA amyloid type→systemic kidney, liver, heart, spleen; most common presentation→renal insuficiency/nephrotic syndrome
Paraneoplasic cause of SIADH secretion. Clinical findings.
- Bronchogenic small cell carcinoma
- confusion, weakness, fatigue, weight gain ▶️ dilutional hyponatremia
Which is the most important determinant of severity of symptoms (degree of cyanosis) and prognosis in tetralogy of fallot?
Pulmonary infundibular stenosis or right ventricular outflow tract obstruction
What laboratory finding (blood smear) do you expect in a patient that has a mutation leading decrease ß-globin chain synthesis? what diagnosis?
- ß-thalassemia→small RBC ↑ central pallor
- Microcytosis, hypochromic RBC, basophilic stippling, anisopoikilocytosis, target cells, teardrop cells, nucleated RBC precursors.
Common association of hyperchromy in blood smear. Cause of that disease.
- Hereditary spherocytosis
- Variety of defects in genes that code for RBC membrane proteins (ankyrin, spectrin, band 3, protein 4.2)
Which diagnose do you suspect in a patient with recurrent intranasal uclers, recent onset renal failure? Which antibodies are associated? Pathologic findings.
- Wegener’s granulomatosis (with polyangiitis)→C-ANCAS (target neutrophil proteinase 3)
- Necrotizing vasculitis of the upper and lower respiratory tract (nasal ulcers, sinusitis, hemoptysis) and rapidly progressive glomerulonephritis
Cause of hypercalcemia in a granulomatous disease? What others diseases show same mechanism and hypercalcemia?
- Sarcoidosis, TB→PTH independent coversion to 1,25 OH Vitamin D→↑Ca intestinal absorption→hypercalcemia and hypercalciuria
- Expression of 1-alpha-hydroxylase in activated macrophages
- Hodgkin disease and non-hodgkin lymphoma
What suggests an elderly patient with nausea, vomiting, mild abdominal pain, CT abdomen scan ileal wall thickening and no enhancement with contrast? Which enzyme would be decreased in activity if patient have lactic acidosis?
- Acute mesenteric ischemia
- Hypoxic enviroment→accumulation of NADH→(-)Pyruvate dehydrogenase (↓ activity)→↑LDH activity►Pyr→Lactate►lactic acidosis
What mutations are involved in Lynch syndrome and what is the consequence in processing the DNA?
- MSH2, MLH1 (MutS, MutL proteins - 90% of lynch syndrome cases) ▶️ Missmatch repair
- Defective DNA Missmatch repair
What do you suspect in a patient that first presents deep vein thrombosis and then middle cerebral artery stroke? How does it happen? Most common causes.
- Paradoxicall embolism ▶️ emboli from systemic venous circulation crosses to systemic arterial circulation through intracardiac or intrapulmonary shunt.
- ASD, patent forman ovale, VSD, large pulmonary arteriovenous malformation
- Transient reversal of the shunt ▶️ left-right shunt condition, become right-left shunt during periods of ⬆️ right side pressure (early ventricular systole, cough, defecation)
Auscultation findings in atrial septal defect.
- Wide and fixed splitting of S2 (no change with respiration) ▶️ equalization of the left and right atrial pressures
- Mid systolic murmur ▶️ ⬆️ flow through pulmonary valve
- Mid diastolic rumble ▶️ ⬆️ flow through tricuspid valve
Which finding in the auscultation do you expect to find in VSD?
- VSD ▶️ most common congenital heart disease (25% of all cases)
- Holosystolic murmur in left sternal border at 3rd or 4th intercostal space
Main features of dysplasia
- Referred only to epithelial cells
- Reversible
- Pleomorphism (differing in shape and size)
- Hyperchromatism
- Disorganized (loss alignment along basement membrane)
- ⬆️ mitoses
- N/C ratio may be ⬆️ (more in carcinoma in situ)
- High-grade dysplasia (entire epithelium) = carcinoma in situ
- Low-grade dysplasia not involve entire epithelium
Functions and location of parietal cells.
- Produce: intrinsic factor→absorption of vitamin B12; gastric acid
- Oxyntic, round, plate-like, in upper glandular layer
Congenital bicuspid aortic valve is associated with what valve disease at 50’s?
Aortic stenosis >50% of afected→accelerated aging process→premature atherosclerosis and calcification
What cells are implicated in centriacinar emphysema and why?
- Neutrophils and Macrophages→elastase, proteases, cathepsines, etc→degrade extracellular matrix; ↑O2 free radicals→inactivated protease inhibitors (alpha1-antitrypsin)►acinar wall destruction (irreversible airspace dilation distal to the terminal bronchioles)
- alpha1-antitrypsin deficiency→panacinar emphysema
What do you suspect if find gastric varices alone at esophagus and rest of stomach normal, which vessel would have increase pressure and why?
- Splenic vein thrombosis ▶️ ⬆️ pressure inside it ▶️ short gastric veins of fundus drain on it ▶️ dilate ▶️ gastric varices
- Splenic vein courses posterior of pancreas ▶️ inflammatory process of pancreas (chronic pancreatitis, cancer) ▶️ clot formation
*gastric varices also seen in portal hypertension (⬆️ pressure in left gastric veins) but with esophageal varices
Which parameter is a measure of visceral fat and an indicator of high risk of insulin resistance, diabetes mellitus and coronary heart disease?
Waist circumference or waist-to-hip ratio
>102 cm (40 inch) in male
>88 cm (35 inch) in women
What vasculitis have a common pathological finding, characterized by granulomatous inflammation of the media? How do you differentiate them?
- Takayasu arteritis ▶️ aorta and proximal aortic arch branch, female <40
- Temporal arteritis (Giant cell arteritis - GCA) ▶️ more distal carotid artery branch, patients >50
*Different clinical presentation. Jaw claudication specific for GCA
What suggest to you a culture of immature cells that differentiate when are exposed to vitamin A in a elderly patient with DIC? Why?
- Acute myelogenous leukemia (Acute promyelocytic leukemia - APL), type M3 ▶️ t(15;17) mutation ▶️ fusion of retinoic acid receptor alpha gene with promyelocytic leukemia gene ▶️ PML/RARɑ ▶️ unable to signal the differentiation
- normally RARɑ ▶️ proper differentiation of myeloid precursors when bind Retinoic acid ▶️ affect genes for maturation. Tx: all-trans-retinoic acid (ATRA) ▶️ partly induce PML/RARɑ proteolysis, (+) differentiation of myeloblasts (remission in 90%)
What condition can result when there is a decreased number of antral cells that produce somatostatin? How does it occur and what is the cause?
- Duodenal ulceration (duodenal gastric metaplasia)
- Helicobacter pylori (damage gastric mucosa by localized inflammation - antral gastritis) ▶️ ⬇️ antral cells somatostatin producers (delta cells) ⏩ ⬆️ gastrin ▶️ ⬆️ H+ (parietal cells)
*somatostatin normally ▶️⬇️ gastrin (antral G cells)▶️ ⬇️ H+ (parietal cells)
Neoplasia associated with myasthenia gravis? Which embryologic origin has the tissue of the neoplasia, what other structures come from that origin?
- Thymoma o thymic hyperplasia
- 3dr pharyngeal pouch→thymus, inferior parathyroid gland
Why chronic kidney disease can lead in secondary hyperparathyroidism?
- CKD ▶️ ❌ 25-hydroxyvitamin D ▶️ 1,25 dihydroxyvitamin D (active form) by 1-alpha hydroxylase. ❌ glomerular and tubular function ⏩ hyperphosphatemia, hypocalcemia, ⬇️ vitamin D ▶️ ⬆️ PTH
- weakness, bone, muscle pain, abnormal bone mineralizarion, ⬆️ risk of fracture.
What suggest and what is a finding of pneumatosis intestinalis in a premature infant with bloody stools and abdominal distention? Why does it occur?
- on X-ray ▶️ air in the bowel wall ▶️ thin curvilinear lucency parallel to the lumen
- Necrotizing enterocolitis
- Immature immune clearance ▶️ initiate enteral feeding ▶️ get in bacterias ▶️ ⬆️ proliferation ▶️ invade bowel wall ▶️ inflammation and ischemic necrosis ▶️ intramural gas collection
What neurotransmitter is changed in alzheimer disease, why?
- Ach in basal nucleus of Meynert (memory and cognition) and hippocampus (new memories formation)
- Choline acetyltransferase deficiency
Cause of hereditary pancreatitis
- Mutations in trypsin gene ▶️ less sensitive trypsin to be cleaved by itself
- Mutations in serine peptIdase inhibitor Kazal type 1 (SPINK1) ▶️ trypsin inhibitor ▶️ avoid activation of trypsinogen prematurely within pancreas (autodigestion)
*premature activation of trypsinogen before it reaches the duodenal lumen ▶️ autodigestion of pancreas
When do you suspect an amniotic fluid embolism? What is the histologic finding?
- During pregnancy or short after delivery ▶️ amniotic fluid [arachidonic acid, tissue factor (thromboplastin)] enter maternal circulation ▶️ uterine trauma sites, cervical lacerations ▶️ anaphylactoid reaction ⏩ occlusion and vasospasm of maternal pulmonary circulation ▶️ left ventricular failure, ⬇️ cardiac output, seve V/Q mismatch ▶️ hypoxia, hypotensive shock ▶️ cardiopulmonary arrest
- Fetal squamous cells and mucin in maternal pulmonary arteries
Classic histologic findings of Burkitt lymphoma. Organism associated with developing of the tumor and why is it related?
- Sheets of diffuse-medium size lymphocyte, high proliferation index (high Ki-67 fraction approaching to 100%), “starry sky” appereance→interspersed “body tingible” macrophages
- EBV→↑risk of c-myc translocation t(8;14)→overexpression of c-myc→nuclear phosphoprotein transcriptional regulator (activator)→control cell proliferation
What is the müllerian aplasia and what study you should make because highly associated anatomical alteration?
- Defective development or congenital absence of müllerian ducts→variable uterine development, no upper vagina►normal ovaries→regular development of secondary sexual characteristics (breast, pubic hair), primary amenorrhea
- Renal ultrasound→50% will have a coexisting urologic anomaly (unilateral renal agenesis)
What condition do you suspect if a young patient has acne, testicular atrophia (in case of female virilization→clitoromegaly, hirsutism), increased hematocrit?
Androgenic steroid abuse
CT findings on constrictive pericarditis and possible causes. Common clinical presentation.
- Thickening and calcification of the pericardium (normally 1-2 mm thick, constrictive pericarditis 4-20 mm)
- Radiation therapy to the chest, cardiac surgery, TB
- Slowly progressive dyspnea, chronic edema, ascitis
What change do you expect to find in a brain after more than 1 month of ischemic stroke? what cells mediate that change?
Cystic area sorrounded by dense glial fibers→astrocytes forming glial scar previously (2 wks after stroke)
What is the most common mutation of the CFTR gene and what is the consequence?
CFTR gene→ATP-gated Cl− channel►secretes Cl− in lungs and GI tract, reabsorbs Cl− in sweat glands
- F508 mutation→Misfolded protein (abnormal postranslational processing)→detected in RER→target for proteasome degradation→not transported to cell membrane→↓Cl− (and H2O) secretion►↑intracellular Cl−→compensatory ↑Na+, H20 reabsorption→thick mucus (bronchioles, pancreatic ducts, bile
ducts, meconium, cervix, seminal fluid)
- ↓Reabsorption of Cl in sweat glands→↑Cl− concentration (> 60 mEq/L) in sweat (Dx)
*Na+ and water follow Cl-→CFTR hydrates mucosal surfaces in the airways and bowel
Why do the patients with cystic fibrosis have elevated chloride in the sweat?
Normally NaCl is removed from the ductal lumen of the eccrine sweat gland→transform isotonic to hypotonic sweat
*Absence of functional CFTR→cannot remove salt from the sweat→↑sweat Cl- (also Na+)
What suggest to you the presence of schistocytes in a blood smear? Possible causes of that mechanism.
♦Hemolytic anemia by traumatic mechanism: RBC damaged when passing through obstructed or narrowed vessel lumina
- Microangiopathic hemolytic anemia→Hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), CID, malignant hypertension, metastatic carcinoma
♦Hemolytic anemia by mechanical damage:
- Macroangiopathic hemolytic anemia→Prosthetic valve, severely calcified valves (aortic stenosis)
- HUS and TPP→normal coagulation studies
- CID→abnormal coagulation studies
Bloody diarrhea a week ago, schistocytes of blood smear and hemolytic anemia, thrombocytopenia, also acute renal failure. Most probably diagnosis and possible cause.
- Hemolytic uremic syndrome (HUS)
- Shiga-like toxin→enterohemorrhagic E. coli (O157:H7) or shigella
Why are the patients with chron disease prone to develop gallstones?
Inflammation at terminal ileum→no enough recycling bile acids→↑bile acids wasting→↑ratio cholesterol/bile acid→precipitation of cholesterol in bile→ gallstones
How do you expect to find the serum markers of a exacerbation (infective) of chronic hepatitis B?
- “Healthy” chronic carrier: HBsAg, anti-HBc IgG→contagious but at a much ↓risk
- Infective chronic carrier: HBsAg, anti-HBc IgG, infective particles (↑HBV DNA, HBeAg), Abrupt ↑ liver enzymes (exacerbation - acute hepatitis)→↑risk for postnecrotic cirrhosis and hepatocellular carcinoma
Most common group of frequency of intussusception, cause associated, representative features in its clinic presentation and most common place of occurence at the GI tract.
- <2 years old children (often without any structural cause, sometimes associated with viral infection)
- In >2 years old→meckel diverticulum, foreign body, intestinal tumor
- “Currant jelly” stools (contain mucus and blood), tubular palpable mass at lower right quadrant
- Ileocecal valve→size differents in adjacents segments→small bowel invaginate into the cecum
Diagnostic and treatment of intussusception
Barium enema→Dx and Tx, if not resolve with it→surgery
Composition of crescents in the kidney. What diseases usually show this finding?
- Abundant Fibrin + plasma proteins (IgG, C3)
- Macrophages, monocytes, glomerural parietal cells
- Rapidly progressive glomerulonephritis (RPGN), Goodpasture syndrome (type 1 RPGN), granulomatosis with polyangiitis, microscopic polyangiitis, etc
How do you distinguish hypercalcemia caused by thiazide diuretic side effect and hyperparathyroidism?
PTH level
- ↓ in thiazide diuretic side effect
- ↑ in Hyperparathyroidism
Typical signs and symptoms of thrombotic thromocytopenic purpura (TTP) and mechanism of disease
- New onset neurologic symptoms, anemia with schistocytes, thrombocytopenia, acute kidney injury, fever, normal PT/PTT, ↑bleeding time, ↑LDH, ↓haptoglobin, cutaneous petechiae, purpuric lesions
- ↓ADAMTS13 (vWF cleaving protease) activity→large vWF multimers→diffuse microvascular platelet rich thrombi
*Acquired (antibodies) or hereditary
When do you think in polyartheritis nodosa? and with what organism is often associated?
- Multisystemic organ involvement (most common kidney, heart, liver, GI tract, muscles)→symptoms will be due ischemia of the involved organs
- Bx→transmural inflammation of the arterial wall with fibrinoid necrosis
- Hepatitis B associated in 30% of cases
Why pheochromocytoma causes hypokalemia? Difference from hyperaldosteronism (also HTN and hypokalemia).
- ⬆️ Epinephrine ▶️ B2 receptor ▶️ intracellular K+ shift
- Unlike hyperaldosteronism, pheochromocytoma ▶️ tachycardia, increased sweating.
Differential diagnosis of patient with hypokalemia, hypertension, ⬆️ renin, ⬆️ aldosterone and muscle weakness. Cause of each one.
Secondary hyperaldosteronism
- Renovascular HTN ▶️ Renal artery stenosis (fibromuscular dysplasia or atherosclerosis)
- Diuretic use
- Malignant HTN ▶️ microvascular damage and renal ischemia
- Renin secreting tumors (Reninoma) ▶️ Juxtaglomerual cell tumor
Lesion in what hypothalamic nuclei can result in hyperphagia and obesity
Ventromedial nucleus ▶️ control satiety and monitor blood glucose levels
How do you identify a Paget disease of bone and which cell type predominates in each of its phases?
- Bone pain, tenderness point, ↑phosphatase alkaline, elderly (until here also bone metastases), Bx→haphazardly oriented segments of lamellar bone with prominent cement lines (mosaic pattern)
1. Osteolytic→osteoclast dominant phase
2. Mixed (osteoclastic/osteoblastic)→↑bone formation with persistent resorption
3. Osteosclerotic→osteoblast dominant phase→continued bone formation
*Thick and deformed bone weaker than normal and prone to fracture
What cardiovascular alteration can result in Paget bone disease and why?
- High-output heart failure
- Osteoclasts→↑cytokines→↑proliferation of endothelial cells and fibroblasts→adjacent marrow spaces replaced by highly vascular stromal tissue (↑vascularity)►arteriovenous shunting
What do you look for in a bone marrow aspirate in a patient with Gaucher disease? In what other tissues can you find them?
- Lipid-laden macrophages (Gaucher cells)→”wrinkled tissue paper”, wrinkled silk”, “crumpled newspaper”
- Liver, spleen, lymph nodes, tonsils, etc
Typical clinical presentation of Gaucher disease
- Bone pain→bone marrow invasion/inflammation
- Abdominal distension→Hepatosplenomegaly
- Easy bruising, fatigue, pallor→Pacytopenia (more common anemia and thrombocytopenia than leukopenia)
Possible causes of pancytopenia without splenomegaly
- Aplastic anemia
- Severe B12 and folate deficiency anemia
- Acute leukemias
- Certain forms of myelodysplastic syndrome
Diagnose and treatment of vWF deficiency.
- Dx→Ristocetin aggregation test→asses in vitro vWF dependent platelet aggregation►poor aggregation that correct when addition normal plasma (contain vWF)
- Tx→combined oral contraceptives for menorrhagia, desmopression (↑release vWF from endothelium)
What is the response to Ristocetin aggregation test in Bernard-soulier syndrome? why?
- Hereditary deficiency of GP Ib receptors→thrombocytopenia, enlarged platelets, mucocutaneous bleeding
- Abnormal aggregation with Ristocetin, but normal plasma addition WON’T correct aggregation (vWF levels are normal, problem is GP Ib receptor)
Rrepresentative feature of congenital deficiency of factor XII (Hageman)
- Marked PTT prolongation without bleeding diathesis
- Tendency for thromboembolic complications
Why do you see hemolysis in pyruvate kinase deficiency? and why do you find splenomegaly?
- Pyruvate kinase deficiency→PEP►Pyruvate (glycolysis)→ATP→need to maintain RBC structure (ATP for transport cations against a concentration gradient in RBC membrane→disrupt gradient→H2O and K+ loss→defective maintain membrane architecture►echinocyte and hemolysis)
- Spleen→red pulp hyperplasia by removing defective RBC
What findings can you see in a blood smear of a glucose 6P dehydrogenase deficiency patient?
Bite cells and Heinz bodies
Mechanism of disease of sickle cell disease and findings in blood smear.
- Missense mutation in beta-globin chain→Hb S→Polymerization in deoxygenated states►RBC membrane injury and deformation (“sickle shape”)
- Drepanocytes
Findings in the blood smear of Thalassemias
- Target cells
- Hypochromic microcytes
Findings in the blood smear of megaloblastic anemia
- Oval cells
- Hypersegmented neutrophils
Classic clinical manifestations and blood smear of Hereditary spherocytosis and mechanism of disease
- Autosomal dominant mutation→spectrin and ankirin (plasma-membrane scaffolding proteins)→spherocytes less deformable→prone to sequestration and destruction by spleen
- Hemolytic anemia, jaundice, splenomegaly
What is the product of c-Myc gene? in what translocation associated to lymphoma is involved and what type of lymphoma causes it? Histologic finding.
- Nuclear phosphoprotein as a transcription activator→cell proliferation, differentiation, apoptosis
- t(8;14)→Burkitt lymphoma
- “Starry sky” appearance, monomorphic intermediate size lymphocytes with round nuclei, multiple prominent nucleoli, vacuolated basophilic cytoplasm
Translocation associated to follicular lymphoma and mantle lymphoma, and their consequences in the cell.
- Follicular lymphoma→t(14;18)→BCL2 overexpression→apoptosis inhibitor
- Mantle lymphoma→t(11;14)→cyclin D1 overexpression→promoter of G1►S-phase transition
Translocation of associated with chronic myelogenous leukemia and its consequence.
- t(9;22) [philadelphia chromosome]→BCR-ABL (resulting fusion gene)→inhibits apoptosis, ↑mitogenesis, ↑tyrosine kinase activity
Causes and mechanism of communicating hydrocephalus and how do you find the ventricles?
- Sequelae of meningeal infection (include TB meningitis) or subarachnoid/intraventricular hemorrhage→dysfunction or obliteration of subarachnoid villi►impair absoprtion of CSF
- Increased CSF production→Ex, choroid plexus papilloma
- All ventriculi symmetrical enlarged
*↑intracranial pressure, papilledema, herniation
Paradoxical brain embolism causes.
- Persistent foramen ovale▶️incomplete fusion of atrial septum primum and secundum
- Atrial septal defect▶️aplasia of the septum primum or septum secundum
How could be the clinical presentation of gestation choriocarcinoma and why? Histologic feature of it.
- Dyspnea, hemoptisis▶️pulmonary metastasis [most common site] (hematogenous spread)
- Anaplasic proliferation of cytotrophoblasts and syncytiotrophoblasts without villi
*Followed by normal pregnancy (usual) or molar, ectopic, aborted. Vagina bleeding, uterine enlargement, ⬆️⬆️ B-hCG
Risk factor for endometrial cancer. What factors can cause it?
- Endometrial hyperplasia▶️crowded endometrial glands lined by atypical cells
- Prolonged exposure to high estrogen levels: obesity, nulliparity, tamoxifen
*vaginal bleeding in a postmenopausal woman
What is the Stewart-Treves syndrome and why could it happen?
- Cutaneous angiosarcoma resulting from chronic lymphedema (risk factor)
- Ex: Radical mastectomy with axillary lymph node dissection. Any cause of chronic lymphedema.
Gas arterial disturbance in high-altitude sickness. Why does it happen?
- Respiratory alkalosis compensated in 24-48 hrs by renal bicarbonate excretion
- Hypobaric hypoxia▶️⬆️altitude▶️⬇️barometric pressure▶️⬇️pO2 in air and blood▶️hypoxia▶️➕peripheral chemoreceptors▶️hyperventilation (try to improve oxygenation)▶️⬇️pCO2
How do you explain the hypercalcemia in multiple myeloma? how are the levels of PTH, urinary calcium, vitamin D and PTHrp?
- Osteolysis induced by tumor cells→↑osteoclasts activating factors (IL-1)
- Myeloma cells→↑Inhibitor of osteoblasts differentiation (DKK1)
- PTH↓, urinary calcium↑, vitamin D↓, PTHrp normal
How do you explain hypercalcemia in granulomatous disorder?
Expression of alpha-1-hydroxylase→↑1,25 dihydroxyvitamin D→↑intestinal absorption of calcium→↑blood calcium→↓PTH, hypercalciuria
*Sarcoidosis, Tuberculosis
What hematologic disturbances can you find in systemic lupus erythematosus and how do they occur?
Type II hypersensitivity reaction:
- Anemia→warm IgG antibodies against RBC→autoimmune hemolysis►spherocytosis, positive direct coombs test, extravascular hemolysis
- Thrombocytopenia→antibodies against platelets (as idiopathic thrombocytopenic purpura)
- Leukopenia→antibodies against neutrophils
In a mitral stenosis what finding about pressures and volumes at the heart suggest a concomitant aortic valve defect? Probably cause of it.
⬆️left ventricular diastolic pressure▶️aortic stenosis and/or regurgitation⏩rheumatic heart disease
*Usually in mitral stenosis alone ▶️⬇️or normal left ventricular diastolic pressure
What is the cause and mechanism of CID in a pregnant woman?
- Placental injury▶️placental trophoblast▶️Tissue factor (thromboplastin)▶️➕coagulation cascade⏩circulating microthrombi▶️organ ischemia, fibrinolysis (⬆️D-dimer) and coagulation factors rapidly consumed (⬇️platelets, ⬆️PT PTT)▶️Bleeding
- Risk factors▶️placental injury (placental abruption), sepsis, postpartum hemorrhage, acute fatty liver of pregnancy, amniotic fluid embolism
Triad on ECG of Wolff-Parkinson-White syndrome
Delta wave
Short PR interval
Widened QRS
Locus of amyloid precursor protein (APP), in what cases it can increase the risk of alzheimer disease?
- Long arm of chromosome 21
- Processing by gamma and beta secretase▶️beta-amyloid⏭not enough cleared, insoluble fibrils▶️extracellular amyloid plaque▶️neurotoxic
*Also ⬆️levels of APP ⬆️risk of alzheimer dementia⏩trisomy 21
What genes participate and what are their functions in adenoma to carcinoma sequence of colon cancer?
- APC▶️tumor suppressor gene▶️⬆️B-catenin▶️uncontrolled cell proliferation▶️progression from normal mucosa to small adenomatous polyp (adenoma)
- KRAS▶️protooncogene▶️unregulated cell growth▶️increase size of adenoma
- TP53▶️tumor suppressor gene▶️apoptosis of cells with damaged DNA (normally), mutation▶️allow cells with bad DNA enter to cell cycle▶️last “hit”▶️carcinoma (malignant transformation)
What is made of the fibrous cap of atheroma plaque and what cell is responsible of its formation?
- Collagen, elastin, proteoglycans
- Vascular smooth muscle cells
What type of antibody is the Rheumatoid factor and against does it react?
- IgM
- Fc portion of human IgG▶️Formation immunocomplexes (IgM-IgG)▶️deposition at sinovium and cartilage▶️complement activation▶️chronic inflammation
What tumor serum marker is elevated in malignant testicular tumor (mainly in nonseminomatous germ cell tumors) and how can you suspect it and why?
- hCG
- Alpha subunits of TSH, LH, FSH and hCG are identical, and Beta subunit is very similar in TSH and hCG▶️⬆️⬆️hCG▶️⬆️T3, T4▶️paraneoplasic hyperthyroidism (also seen in gestational trophoblastic disease)
*Alpha-phetoprotein also ⬆️ but doesn’t cause hyperthyroidism
Cystic degeneration of putamen is characteristic of what disease?
Some progressive neurologic disease, but most likely▶️Wilson’s disease
Translocation associated to Burkitt lymphoma and their consequences in the cell.
- t(8;14)▶️c-myc oncogene on heavy Ig chain
- t(8;22)▶️c-myc oncogene on Ig lambda light chain
- t(8;2)▶️c-myc oncogene on Ig kappa light chain
- All result in overexpression of the oncogene
Key finding and description of stages of acute tubular necrosis
- Granular (“muddy blrown”) casts
1. Inciting event→36 hours, slight ↓ in urine output
- Maintenance phase (1-3 wks): follow 24-36 hrs, ↓urine output (oliguric), ↑BUN, Cr (BUN:Cr <15), high anion gap metabolic acidosis, ↑extracellular fluid volume, ↓Na, ↓Ca, ↑PO4, ↑Mg, ↑K, ↓urinary osmolarity (<350), ↑urinary Na (>30), ↑FeNa>1
- Recovery phase: follow 1-2 wks. Impair tubular reabsorption and concentrating ability→polyuric (>3L/day), hypotonic urine→↓Mg, ↓PO4, ↓Ca (deposition and ↓Vit D), ↓K (most serious complication of this phase), ↓BUN,Cr.
Common causes of acute tubular necrosis
- Ischemic→↓renal blood flow (hypotension, shock, sepsis, hemorrhage, HF)►PCT, thick ascending limb→↑susceptible to injury
- Nephrotoxic→Drugs (aminoglycosides, cisplatin, sulfonamides, methycilin, polymyxin), radiocontrast agents, heavy metals (lead, mercury, gold), organic solvents (carbon tetrachloride, chloroform, methyl alcohol), crush injury (myoglobinuria), etc►PCT susceptible to injury
Where is the origin of the stanford type B and A aortic dissection?
- Type A→sinotubular junction►involve any part of ascending aorta
- Type B→close to the origin of the left subclavian artery►involve the descending aorta (no ascending)
- Aortic arch involvement→distal propagation of type A, proximal propagation of type B.
- Thoracoabdominal aorta involvement→both type distal propagation
Clinical manifestation of Wiskott-Aldrich syndrome? Cause and mechanism of them.
- X-linked disorder→combined B and T-lymphocyte dirsorder
- Eczema
- Recurrent infections→pyogenic infections→inability of hummoral response against organisms with polysaccharide capsule. T cell defect→oportunistic infections (herpes or pneumocystis)►after 6 to 12 mo of birth
- Thrombocytopenia→petechiae, purpura, hematemesis, epistaxis
What type of acid-base disturbance can you find in septic shock?
- High anion-gap metabolic acidosis, secondary to:
- Lactic acidosis►End organ hypoperfusion→↓oxidative phosphorylation→↑NADH→shunt Pyr to Lac(↑)→continue glycolysis
*Hepatic hypoperfusion→↑Lactate►primary site of lactate clearance
Clinical clues to suspect acute interstitial nephritis, and most common causes.
- Acute renal failure (azotemia), ↑IgE serum and eosinophilia, eosinophiluria, fever, maculopapular rash
- 1-3 wks after initiation of: B-lactam antibiotic, diuretics, sulfonamides, rifampin, NSAIDS, proton pump inhibitors
What type of urinary incontinence is due multiple sclerosis and why?
- Urge incontinence→detrussor overactivity
- Regions in pons and cerebral cortex partially inhibit micturition reflex (also regulate contraction/relaxation of external urethral sphincter)→involved area in MS (above sacral region)→loss of higher center control→detrussor hyperreflexia´
*As disease progress bladder become atonic and dilated→overflow incontinence
What suggest a C1 that when is not attached to Ag-Ab complex is excessively cleaving C2 and C4 (inappropriate activation of the complement cascade)? why?
- C1 inhibitor (C1INH) deficiency→normally blocks kallikrein-induced conversion of kininogen to bradykinin►potent vasodilator→↑vascular permeability
- Facial swelling (without urticaria), laryngeal edema, GI symptoms (nausea, vomiting, colicky)
What is the manifestation of a enteropeptidase deficiency?
Fat and protein malabsorption→diarrhea, failure to thrive, edema (hypoproteinemia)
*Fail to produce trypsin→break polypeptides and activates enzymes for protein and lipid digestion (pancreatic enzymes)
What type of cells become hypertrophic and make hyperplasia in chronic renal hypoperfusion (stenosis)? Why?
- Juxtaglomerular cells of the afferent arteriole (main location) [modified smooth muscle cells]
- Hypoperfusion▶️➕RAAS▶️JG cell synthesize renin▶️chronic ➕▶️hypertrophy and hyperplasia
Mechanism by which rickets result
⬇️⬇️Vitamin D levels (⬇️conversion to active form or ⬇️intake)▶️⬇️Ca and PO4▶️unmineralized bone matrix and epiphyseal (growth plate) cartilage
In a severe hypotensive patient which zones of the colon would be mainly affected and why?
Nonocclusive ischemia at margins of anastomotic distributions▶️”watershed” areas▶️splenic flexure (border between SMA and IMA), rectosigmoid junction (border between sigmoid and superior rectal artery) [Left colon]
*Ischemia and necrosis of intestinal wall▶️colonoscopy⏩pale mucosa and petechial hemorrhage
What mean a gastric erosion?
*Mainly causes of gastric ulcers
Lesion that extend into (not completely through) the muscularis mucosa▶️acute erosive gastropathy⏩alcohol, tobaco, NSAIDs, surgical stress, head trauma (cushing), burns (curling)
*Completely through muscularis mucosa▶️ulcer (extend into the submucosal layers and muscularis propia)⏩1.Helicobacter pylori, 2.NSAIDs
Clinical manifestations of acute erosive gastropathy
- Asymptomatic
- Life threatening upper GI bleeding (melena, etc)
- Nausea, vomiting, epigastric pain (most common)
Single most important risk factors for aortic dissection and aneurysm
- Aortic dissection▶️Hypertension (intimal tears)
- Aortic aneurysm▶️Atherosclerosis (abdominal>thoracic)
Histologic findings of celiac disease
Villous atrophy, crypt hyperplasia, intraepithelial lymphocyte infiltration
What changes suggest an irreversible neuronal damage, and what is the response to repair it?
- Neuronal shrinkage, intense cytoplasmic eosinophilia
- Gliosis→glial hyperplasia→astrocytic processes form closely connected meshwork→gliotic scar
Histolopathologic changes of acute tubular necrosis.
- Maintenance phase
- Proximal tubular cell balooning, vacuolar degeneration
- Patchy loss of tubular epithelial cells
- Denudation of basement membrane
- Interstitial edema
- Recovery phase
- Re-epithelization of tubules (gradually)
What suggest calcium oxalate crystals in tubular lumen and/or urinanalysis in a patient with acute renal failure?
- Ethylene glycol poisoning►metabolized by GI tract→glycolic acid (toxic to renal tubules) and oxalic acid (precipitation as calcium oxalate)
- Acute tubular necrosis→high anion gap metabolic acidosis, osmolar gap
What type of alteration in bladder would you expect to find in multiple sclerosis? Why does it occur and what do you expect find in urodynamic study?
Few weeks after acute spinal cord lesion (MS attack)▶️Spastic bladder (bladder hypertonia in urodynamic study▶️little or no residual urine after emptying▶️poor distensibility)▶️⬆️urinary frequency and urge incontinence
*Upper motoneuron lesion▶️loss descending inhibitory control on bladder▶️doesn’t relax/distend
Cause of flaccid bladder. Common finding in urodynamic study.
- Lower motor neuron lesion (ex, cauda equina syndrome)▶️urinary incontinence at the end of theh day
- Large residual volume after emptying
What is the consequence of the change of Hb in sickle cell disease (HbS)?
HbS▶️glu (negative charge)⏩val (neutral charge) susbtitution (missense mutation)▶️6th aa in B-globin chain▶️hydrophobic interaction among Hb▶️HbS polymerization and RBC sickling
- Promote by low oxygen levels, ⬆️acidity, dehydration
- ↓Negative charge→move more slowly toward anode in electrophoresis
Consequence of the change in Hb on HbC disease.
HbC▶️glu (negative charged)⏩lys (positive charged) (missense mutation)▶️less severe symptoms than sickle cell disease▶️hydrophobic interactions between Hb doesn’t occur
*↓↓Negative charge→move even more slowly toward anode in electrophoresis
Mechanism of Zenker (false) diverticulum
Cricopharyngeal motor dysfunction▶️spasms, ⬇️relaxation of cricopharyngeal muscles during swallowing
Complications of subarachnoid hemorrhage.
*Cause of it.
- Vasospasm (most frequent)▶️impaired brain autoregulation (prevent - Nimodipine)
- Rebleeding (most dangerous, no most common▶️30%)
- Hydrocephalus▶️irritation and dysfunction of arachnoid villi
*Rupture of berry aneurysm
Important histologic features of Schwannoma.
- Antoni A pattern▶️⬆️cellularity regions⏩spindle cells, oval nuclei in palisading; interspersed;
- Antoni B pattern▶️⬇️cellularity myxoid regions
- Verocay bodies▶️nuclear free zones interspersed in Antoni A
- S-100 (+)▶️neural crest cell origin (as melanoma)
*Most common site cerebellopontine angle at CN VIII. Peripheral nerves, nerve roots, CN (except II CN - covered by oligodendrocytes)
With which conditions is associated the xanthelasmas?
Primary biliary cirrhosis
Where do you find the amatoxins? How can cause alterations and what can cause? How do you diagnose?
- Poisonous mushrooms (Amanita phalloides [death cap])▶️🚫RNA polymerase II▶️🚫mRNA
- 6-24 hrs after ingestion▶️abdominal pain, vomiting, severe cholera-like diarrhea (blood and mucus), acute hepatic and renal failure
- Urine alpha-amanitin
What is the acute/subacute clinical presentation of acute rheumatic fever and its chronic feature? Of the acute features which is the major morbidity?
- Migratory arthritis, sydenham chorea, pancarditis (major morbidity▶️severe myocarditis▶️cardiac dilation▶️HF▶️death)
- Chronic: mitral stenosis/regurgitation
*In acute setting inflammation of mitral valve▶️mitral regurgitation▶️new holosystolic murmur
Serum levels in primary osteoporosis of PO4, Ca, PTH.
Normal levels
What is the most common manifestation of primary osteoporosis and why?
Early postmenopausal osteoporosis involved cancellous bone▶️integrity of vertebral column⏩vertebral fractures
Distinctive histopathologic finding of hepatitis B infection
“Ground-glass” hepatocytes▶️Finely granular, diffusely homogenous, pale eosinophilic cytoplasm▶️accumulation of Hepatitis B surface antigen
What vitamins and compound deficiencies can you find after gastric pass procedures? Ex, Bilroth II (gastrojejunostomy)
Iron, vitamin B12, folate, vitamin D and calcium▶️predominantly absorbed at duodenum and proximal jejunum (leaved as blind loop in Bilroth II)
*As gastric Antrum is removed▶️⬇️gastrin▶️⬇️acid▶️⬇️iron absorption
Mutation associated with MEN2 syndromes. Why may you find episodic headache as one of symptoms in MEN2B?
- Germline mutations of the RET protooncogene
- Pheochromocytoma associated▶️episodic catecholamines secretion (also paroxysmal hypertension, flushing, diaphoresis)
*Medullary thyroid cancer (⬆️calcitonin), mucosal neuromas, marfanoid habitus.
Important features of vesicoureteral reflux (VUR) and why does it occurs?
- Recurrent pyelonephritis▶️retrograde urine flow from bladder▶️renal scarring in upper and lower poles, dilated calyces, cortical atrophy bilaterally
- Secondary hypertension
Presentation and cause of posterior urethral valve
- Hydronephrosism, calyceal dilatation▶️obstruction of urine flow in the urethra
- Malformation of wolffian duct▶️only occur in males
Which regions of the lymph nodes are absent in DiGeorge syndrome and agammaglobulinemia and why?
- DiGeorge syndrome▶️⬇️T-cells▶️paracortex region
- Agammaglobulinemia▶️⬇️B-cells▶️germinal centers and primary lymphoid follicles
What could decrease the development of clinical peripheral edema in patient with COPD secondary cor-pulmonale?
Cor-pulmonale▶️right side heart failure▶️⬆️central venous pressure (CVP)▶️⬆️plasma hydrostatic pressure▶️transudation to interstitial tissue▶️⬆️interstitial hydrostatic pressure▶️⬆️lymphatic drainage
*If ⬆️⬆️CVP▶️interstitial hydorstatic pressure overwhelm lymphatic drainage capacity▶️edema