Pathology Flashcards
4 drugs for treatment of Alzheimers
- Donepezil
- galantamine
- rivastigmine
- Memantine
ALK:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
ALK
oncogene
receptor tyrosine kinase
Lung Adenocarcinoma
BCR-ABL:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm (2)
BCR-ABL t(9,22)
oncogene
tyrosine kinase
CML/ALL
BCL-2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm(2)
BCL-2
oncogene
Anti-apoptotic molecule (inhib apoptosis)
Follicular Lymphoma & DLBCL
BRAF:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm(2)
BRAF
oncogene
Serine/threonine kinase
Melanoma & non-Hodgkin Lymphoma
c-KIT:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
c-KIT
oncogene
cytokine receptor
Gastrointestinal stromal tumor (GIST)
c-MYC:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
c-MYC t(8,14)
oncogene
transcription factor
Burkitt lymphoma
HER2/neu (c-erbB2): Oncogene or Tumor Suppressor Gene Gene product Associated Neoplasm treatment
HER2/neu (c-erbB2) oncogene tyrosine kinase Breast and gastric carcinoma -->Herceptin/trastuzumab
JAK2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
JAK2
oncogene
tyrosine kinase
chronic myeloproliferative disorders
KRAS:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm(3)
KRAS
oncogene
GTPase
Colon/lung/pancreatic cancer
MYC-L1:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
MYC-‘L’1
oncogene
transcription factor
‘L’ung tumor
MYC-N:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
MYC-‘N’
oncogene
transcription factor
‘N’euroblastoma
RET:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
RET (chrom 10)
oncogene
tyrosine kinase
MEN 2A/2B, medullary thyroid cancer
APC:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
APC
tumor suppressor gene
—
Colorectal cancer (associate with FAP)
BRCA1/BRCA2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
BRCA1/BRCA2
tumor suppressor gene
DNA repair protein
Breast & Ovarian Cancer
CDKN2A:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
CDKN2A
tumor suppressor gene
p16 (blocks G1–>S phase)
Melanoma & pancreatic cancer
DCC:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
DCC
tumor suppressor gene
DCC “Deleted in Colon Cancer”
Colon cancer
DPC4/SMAD4:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
DPC4/SMAD4
tumor suppressor gene
DPC “Deleted in Pancreatic Cancer”
Pancreatic Cancer
MEN1:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
MEN1 (chrom 11)
tumor suppressor gene
melin
MEN1
NF1:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
NF1 (chrom 17)
tumor suppressor gene
Ras GTPase activating protein (neurofibromin)
Neurofibromatosis 1
NF2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
NF2
tumor suppressor gene
Merlin (schwannomin) protein
Neurofibromatosis 2
PTEN:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
PTEN
tumor suppressor gene
decrease PTEN= increase estrogen sensitivity
Breast, Endometrial, & prostate cancers
Rb:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
Rb (chrom 13)
tumor suppressor gene
inhib E2F (block G1–>S phase)
Retinoblastoma & Osteosarcoma
TP53:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
TP53 (chrom 17)
tumor suppressor gene
p53–>activates p21 (block G1–>S)
Most human cancers/ Li-Fraumeni syndrome
TSC1:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
TSC1
tumor suppressor gene
Hamartin protein
Tuberous Sclerosis
TSC2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
TSC2
tumor suppressor gene
Tuberin protein
Tuberous Sclerosis
VHL:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
VHL (chrom 3)
tumor suppressor gene
inhib hypoxia inducible factor 1a
VHL disease, RCC
WT1/WT2:
Oncogene or Tumor Suppressor Gene
Gene product
Associated Neoplasm
WT1/WT2 (chrom 11)
tumor suppressor gene
–
Wilms Tumor (nephroblastoma)
Carcinogen: Aflatoxins (Aspergillus)
Organ
impact
Liver= Hepatocellular carcinoma
Carcinogen: Alkylating Agents (chemo)
Organ
impact
blood = Leukemia/Lymphoma
Carcinogen: Aromatic amines (benzidine, 2-naphthylamine)
Organ
impact
Bladder= Transitional cell carcinoma
Carcinogen: Arsenic
Organ
impact
Liver = angiosarcoma Lung= SCC lung cancer skin= SCC
Carcinogen: Asbestos
Organ
impact
Lung = Bronchogenic carcinoma > mesothelioma
Carcinogen: Carbon tetrachloride
Organ
impact
Liver = Centrilobular necrosis & Fatty change
Carcinogen: Cigarette smoke
Organ
impact
Bladder= Transitional cell Ca. Cervix = Cervical carcinoma Esophagus = SCC/adenocarcinoma Kidney = Renal cell carcinoma Larynx = SCC Lung= SCC & small cell carcinoma Pancreas - Pancreatic adenocarcinoma
Carcinogen: Ethanol
Organ
impact
Esophagus= SCC Liver = Hepatocellular carcinoma
Carcinogen: Ionizing radiation
Organ
impact
Thyroid = Papillary thyroid carcinoma Blood= leukemia
Carcinogen: Nitrosamine (smoked foods)
Organ
impact
stomach = gastric cancer (esp. in Japan)
Carcinogen: Radon
Organ
impact
Lung = Lung cancer (2nd leading cause after cigarette smoke)
Carcinogen: Vinyl chloride (PVC)
Organ
impact
Liver= Angiosarcoma
3 causes of Angiosarcoma
“VAT”
- vinyl chloride
- arsenic
- thorotrast
2 major risk factors for Leukemia
- alkalating agents
2. radiation
EBV associated cancers (4)
- Burkitte
- Hodgkin (Reed sternberg cells)
- Nasopharyngeal
- Primary CNS Lymphoma in immunocompromised
Serum tumor marker:
Alkaline phosphatase
- Mets to bone or liver
- Paget disease of bone
- seminoma (placenta ALP)
Serum tumor marker:
a-fetoprotein (AFP)
- Hepatocellular ca.
- hepatoblastoma
- yolk sac tumor
- mixed germ cell tumor (typically have some yolk part)
Serum tumor marker:
B-hCG
- Hydatidiform moles
- Choriocarcinomas
- testicular cancer
- mixed germ cell tumor
Serum tumor marker:
CA 15-3/ CA 27-29
Breast cancer
Serum tumor marker:
CA 19-9
Pancreatic adenocarcinoma
Serum tumor marker:
CA 125
Ovarian cancer
Serum tumor marker:
Calcitonin
Medullary thyroid carcinoma
(b/c medullary c-cells make calcitonin)
(associated with MEN 2a/2b)
Serum tumor marker:
CEA (CarinoEmbryonic Antigen)
- colorectal cancer
- pancreatic cancer
- gastric cancer
- breast cancer
- medullary thyroid cancer
Serum tumor marker:
PSA
- Prostate cancer
- BPH
- prostatitis