Immuno- GOOD

Question 1

Cyclosporine and Tacrolimus both have what common ADR that is NOT seen in Sirolimus treatment?

Answer 1

• NEPHROPATHY!!!

- Kidneys SIRvive SIRolimus

Question 2

ADR that is seen in cyclosporine but not tacrolimus therapy?

Answer 2

-gingival hyperplasia + hirsutism

Question 3

Cyclosporine binds ______ to inhibit ______ which prevents _______.

Answer 3

Cyclophilin –> calcineurin –> IL2 transcription

Question 4

Tacrolimus binds ______ to inhibit ______ which prevents ________.

Answer 4

FK506 binding protein (FKBP) –> calcineurin –> IL2 transcription

Question 5

Sirolimus binds ______ to inhibit _______ which prevents ______.

Answer 5

FKBP –> mTOR –> IL2 response

Question 6

ADR assc with sirolimus treatment?

Answer 6

-pancytopenia (panSIRtopenia)

Question 7

Daclizumab and basiliximab are Abs against _____.

Answer 7

IL2R

Question 8

Azathioprine is a precursor to ______.

• MOA?
• Shouldnt be combined with ______.

Answer 8

-6MP
-blocks purine syntehesis in B + T cells
(azathioPURINE)
-Dont combine with allopurinol because it is degraded by Xanthine Oxidase (^^^ levels/ toxicity with allopurinol)

Question 9

Mycophenolate mofetil inhibits ______ which prevents ______.

-assc with what infection?

Answer 9

• IMP dehydrogenase
• purine synthesis in B + T cells
• invasive CMV infxn

Question 10

Corticosteroids inhibit _____.

-most pertinent ADR?

Answer 10

• nfkb; decreased cytokines + T cell apoptosis

- iatrogenic cushings

Question 11

Aldesleukin is recombinant _____.

Answer 11

IL2 (renal cell/ met. melanoma tx)

Question 12

Filgrastim and Sagramostim act as _____.

Answer 12

GM-CSF (allow bone marrow recovery)

Question 13

Which IFN is used in MS treatment?
Which IFN is ued in CGD treatment?
Which IFN is used in Hep/Kaposci/malignant melanoma?

Answer 13

-MS: IFN-B
(B treats the "B"rain disease)
-CGD: IFN y
("G"amma --> "G"ranulomatous)
-Hep/Kaposci/melanomia: IFN a 
(a treats "A" lot of random shit.)

Question 14

Oprelvekin is the same as ______.

Answer 14

-thrombopoietin

= ^^ platelets in thrombocytopenia

Question 15

Romiplostin + eltrombopag MOA

Answer 15

-thrombopoietin receptor agonists

both have “rom” in them

Question 16

Alemtuzumab:
target
use

Answer 16

• CD52

- CLL (lem –> LEMphocytic leukemia); MS

Question 17

Bevacizumab/ Ranibizumab
target
use

Answer 17

-VEGF
(BeVa = “B”lood “V”essels b/c VEGF = angiogenesis) (or “Beverly RAN for VEGetables”)
-colorectal/ renal cell cx/ macular degeneration

Question 18

Cetuximab:
target
use

Answer 18

-EGFR
-colorectal/ head and neck cx
(“C”etuximab = “C”olorectal)

Question 19

Rituximab:
target
use

Answer 19

CD20
-non Hodgkins
-CLL
-RA
others 

( I really wouldn’t stress memorizing the whole list)

Question 20

Trastuzumab:
target
use

Answer 20

-HER2Neu
“trasTOOzumab” =herTOOneu
Breast cx

Question 21

Certolizuman
Adalimumab
Infliximab
all inhibit _____.

How is etanercept related to these drugs?

Answer 21

• TNFa

- EtanerCEPT is a TNFa decoy reCEPTor

Question 22

Eculizumab is an ab against?

Treats?

Answer 22

C5; paroxysmal nocturnal hemoglobinuria

Question 23

Natalizumab is an ab aginst?
used in?
very important assc risk?

Answer 23

-a4 integrin
-MS
-**risk of PML in patients with JC Virus!!!!
“NATA” good idea in JC Virus!!

Question 24

Abciximab is an ab against?

When is it used?

Answer 24

-GIIb/IIIa
( II times III = abSIXimab)
-used during percutaneous coronary intervention

Question 25

Denosumab is an ab against?

Answer 25

-RANKL = osteoclast inhibition

Question 26

Antidote for digoxin therapy?

Answer 26

-Digoxin immune Fab

Question 27

Omalizumab is an antibody against?

Used in?

Answer 27

• OH MY EYES (OMA(L)IZ) ITCH CAUSE I HAVE ALLERGIES.

- Against IgE, treats allergies

Question 28

Palivizumab is ab ab against?

Answer 28

-RSV F protein
-Use as prophylaxis in high risk babies
“P” for “prophylaxis”