Immuno- GOOD Flashcards

1
Q

Cyclosporine and Tacrolimus both have what common ADR that is NOT seen in Sirolimus treatment?

A
  • NEPHROPATHY!!!

- Kidneys SIRvive SIRolimus

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2
Q

ADR that is seen in cyclosporine but not tacrolimus therapy?

A

-gingival hyperplasia + hirsutism

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3
Q

Cyclosporine binds ______ to inhibit ______ which prevents _______.

A

Cyclophilin –> calcineurin –> IL2 transcription

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4
Q

Tacrolimus binds ______ to inhibit ______ which prevents ________.

A

FK506 binding protein (FKBP) –> calcineurin –> IL2 transcription

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5
Q

Sirolimus binds ______ to inhibit _______ which prevents ______.

A

FKBP –> mTOR –> IL2 response

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6
Q

ADR assc with sirolimus treatment?

A

-pancytopenia (panSIRtopenia)

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7
Q

Daclizumab and basiliximab are Abs against _____.

A

IL2R

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8
Q

Azathioprine is a precursor to ______.

  • MOA?
  • Shouldnt be combined with ______.
A

-6MP
-blocks purine syntehesis in B + T cells
(azathioPURINE)
-Dont combine with allopurinol because it is degraded by Xanthine Oxidase (^^^ levels/ toxicity with allopurinol)

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9
Q

Mycophenolate mofetil inhibits ______ which prevents ______.

-assc with what infection?

A
  • IMP dehydrogenase
  • purine synthesis in B + T cells
  • invasive CMV infxn
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10
Q

Corticosteroids inhibit _____.

-most pertinent ADR?

A
  • nfkb; decreased cytokines + T cell apoptosis

- iatrogenic cushings

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11
Q

Aldesleukin is recombinant _____.

A

IL2 (renal cell/ met. melanoma tx)

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12
Q

Filgrastim and Sagramostim act as _____.

A

GM-CSF (allow bone marrow recovery)

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13
Q

Which IFN is used in MS treatment?
Which IFN is ued in CGD treatment?
Which IFN is used in Hep/Kaposci/malignant melanoma?

A
-MS: IFN-B
(B treats the "B"rain disease)
-CGD: IFN y
("G"amma --> "G"ranulomatous)
-Hep/Kaposci/melanomia: IFN a 
(a treats "A" lot of random shit.)
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14
Q

Oprelvekin is the same as ______.

A

-thrombopoietin

= ^^ platelets in thrombocytopenia

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15
Q

Romiplostin + eltrombopag MOA

A

-thrombopoietin receptor agonists

both have “rom” in them

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16
Q

Alemtuzumab:
target
use

A
  • CD52

- CLL (lem –> LEMphocytic leukemia); MS

17
Q

Bevacizumab/ Ranibizumab
target
use

A

-VEGF
(BeVa = “B”lood “V”essels b/c VEGF = angiogenesis) (or “Beverly RAN for VEGetables”)
-colorectal/ renal cell cx/ macular degeneration

18
Q

Cetuximab:
target
use

A

-EGFR
-colorectal/ head and neck cx
(“C”etuximab = “C”olorectal)

19
Q

Rituximab:
target
use

A
CD20
-non Hodgkins
-CLL
-RA
others 

( I really wouldn’t stress memorizing the whole list)

20
Q

Trastuzumab:
target
use

A

-HER2Neu
“trasTOOzumab” =herTOOneu
Breast cx

21
Q

Certolizuman
Adalimumab
Infliximab
all inhibit _____.

How is etanercept related to these drugs?

A
  • TNFa

- EtanerCEPT is a TNFa decoy reCEPTor

22
Q

Eculizumab is an ab against?

Treats?

A

C5; paroxysmal nocturnal hemoglobinuria

23
Q

Natalizumab is an ab aginst?
used in?
very important assc risk?

A

-a4 integrin
-MS
-**risk of PML in patients with JC Virus!!!!
“NATA” good idea in JC Virus!!

24
Q

Abciximab is an ab against?

When is it used?

A

-GIIb/IIIa
( II times III = abSIXimab)
-used during percutaneous coronary intervention

25
Q

Denosumab is an ab against?

A

-RANKL = osteoclast inhibition

26
Q

Antidote for digoxin therapy?

A

-Digoxin immune Fab

27
Q

Omalizumab is an antibody against?

Used in?

A
  • OH MY EYES (OMA(L)IZ) ITCH CAUSE I HAVE ALLERGIES.

- Against IgE, treats allergies

28
Q

Palivizumab is ab ab against?

A

-RSV F protein
-Use as prophylaxis in high risk babies
“P” for “prophylaxis”