Immuno- GOOD Flashcards
Cyclosporine and Tacrolimus both have what common ADR that is NOT seen in Sirolimus treatment?
- NEPHROPATHY!!!
- Kidneys SIRvive SIRolimus
ADR that is seen in cyclosporine but not tacrolimus therapy?
-gingival hyperplasia + hirsutism
Cyclosporine binds ______ to inhibit ______ which prevents _______.
Cyclophilin –> calcineurin –> IL2 transcription
Tacrolimus binds ______ to inhibit ______ which prevents ________.
FK506 binding protein (FKBP) –> calcineurin –> IL2 transcription
Sirolimus binds ______ to inhibit _______ which prevents ______.
FKBP –> mTOR –> IL2 response
ADR assc with sirolimus treatment?
-pancytopenia (panSIRtopenia)
Daclizumab and basiliximab are Abs against _____.
IL2R
Azathioprine is a precursor to ______.
- MOA?
- Shouldnt be combined with ______.
-6MP
-blocks purine syntehesis in B + T cells
(azathioPURINE)
-Dont combine with allopurinol because it is degraded by Xanthine Oxidase (^^^ levels/ toxicity with allopurinol)
Mycophenolate mofetil inhibits ______ which prevents ______.
-assc with what infection?
- IMP dehydrogenase
- purine synthesis in B + T cells
- invasive CMV infxn
Corticosteroids inhibit _____.
-most pertinent ADR?
- nfkb; decreased cytokines + T cell apoptosis
- iatrogenic cushings
Aldesleukin is recombinant _____.
IL2 (renal cell/ met. melanoma tx)
Filgrastim and Sagramostim act as _____.
GM-CSF (allow bone marrow recovery)
Which IFN is used in MS treatment?
Which IFN is ued in CGD treatment?
Which IFN is used in Hep/Kaposci/malignant melanoma?
-MS: IFN-B (B treats the "B"rain disease) -CGD: IFN y ("G"amma --> "G"ranulomatous) -Hep/Kaposci/melanomia: IFN a (a treats "A" lot of random shit.)
Oprelvekin is the same as ______.
-thrombopoietin
= ^^ platelets in thrombocytopenia
Romiplostin + eltrombopag MOA
-thrombopoietin receptor agonists
both have “rom” in them