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Step Study Notes > Pathology > Flashcards

Pathology Flashcards

1
Q

Proteins for leukocyte rolling

A

Leukocyte: Mucin-like CAM + Sialyl Lewis Glycosylation, L-selectin

ET: E selectin, P selectin, GlyCAM1, CD34

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2
Q

Proteins for stable adhesion

A

Leukocyte: CD11/18 Integrins (LFA1, Mac1), VLA4 integrin

ET: ICAM1, VCAM1

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3
Q

Proteins for diapedesis

A

Leukocytes and ET: PECAM1

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4
Q

Proteins for chemotaxis through tissue

A

Chemotactic agents: C5a, IL8, LTB4, Kallikrein, Platelet activating factor

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5
Q

BCR-ABL

A

CML

ALL

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6
Q

BCL2

A

Follicular Lymphoma

Undifferentiated Lymphoma

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7
Q

BRAF

A

Melanoma

NHL

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8
Q

c-KIT

A

GIST

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9
Q

c-Myc

A

Burkitt Lymphoma

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10
Q

Her2/Neu

A

Breast
Ovarian
Gastric carcinomas

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11
Q

L-myc

A

Lung cancer

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12
Q

N-myc

A

Neuroblastoma

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13
Q

RAS

A

colon cancer
lung cancer
pancreatic cancer

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14
Q

RET

A

MEN2A, 2B

Medullary thyroid cancer

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15
Q

APC

A

colorectal cancer (FAP)

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16
Q

BRCA1,2

A

Breast cancer

ovarian cancer

17
Q

DCC

A

Colon Cancer

18
Q

DPC4/SMAD4

A

Pancreatic cancer

19
Q

MEN1

A

MEN1

20
Q

NF1

A

Neurofibromin/RAS GTPase-activating protein

21
Q

NF2

A

Merlin/Schwannomin protein

22
Q

p16

A

melanoma

p16 is CDK2a

23
Q

p53

A

most cancers
Li Fraumeni syndrome
(TF for p21, blocks G1 to S transition)

24
Q

PTEN

A

Breast cancer
prostate cancer
endometrial cancer

25
Q

Rb

A

retinoblastoma
osteosarcoma
(Inhibits E2F, blocks G1 to S transition)

26
Q

TSC1

A

hammartin in tuberous sclerosis

27
Q

TSC2

A

tuberin in tuberous sclerosis

28
Q

VHL

A

VHL disease
renal cell carcinoma
(VHL inhibits HIF1a)

29
Q

WT1,2

A

Nephroblastoma (wilm’s tumor)

Step Study Notes (5 decks)

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