Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step Study Notes > IMM > Flashcards

IMM Flashcards

1
Q

Macrophages secrete:

A

IL1: osteoclast activatingfactor, fever, acute inflammation, activates ET cells to express adhesion molecules, induce chemokine secretion to recruit WBCs

IL6: fever, acute phase proteins

IL8: neutrophil chemotactic agent

IL12: Induce Th1 differentiaion, activate NK

TNFalpha: septic shock, activate ET, WBC recruitment, vascular leak, cachexia in chronic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T cells (all) secrete:

A

IL2: stimulate Th, CD8+ and Treg cells and NK cells

IL3: support bone marrow cell growth and differentiation (similar to GMCSF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Th1 cells secrete:

A

IFN gamma: stimulate CD8 cytotoxic T cells, stimulate macrophages to kill engulfed pathogens, NK cells to kill infected cells, increase MHC expression and APC activity

IL2 & 3

  • also secreted by NK cells in response to IL12 from macrophages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Th2 cells secrete:

A

IL 2 & 3

IL4: induce Th2 differentiation, promote growth of B cells and enhance class switching (with help of IL13)

IL5: growth and differentiation of eosinophils, promotes differentiation of B cells, enhance class swiching to IgA

IL10: modulates inflammatory response (anti-inflammatory cytokine), decreases MHCII and Th1 cytokine expression, inhibits activated macrophages and dendritic cells,

IL13: help IL4 in B cell class switch

  • IL10 is also secreted by Treg along with TGFbeta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Induces differentiation of Th1 cells:

Blocks differentiation of Th1 cells:

A
  • IL12 (from macrophages) and IFN gamma induces

- IL4 and IL10 from Th2 blocks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Induces differentiation of Th2 cells:

Blocks differentiation of Th2 cells:

A
  • IL4 induces

- IFN gamma from Th1 blocks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Induces Treg:

A
  • TGF beta and IL6
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CD40 is on __ cells and binds to___ on ___ cells during ___

A

CD40 is on B cells and macrophages and binds to CD40L on Th cells during Th-stimulated activation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CD28 is on ___ cells and binds to ___ on ___ cells during ___

A

CD28 is on T cells and binds to B7 on the antigen-presenting cell during activation of a naive T cell.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MHCI is on ___ cells and is used for ___. It binds to ___.

A

MHC1 is on all nucleated cells and is for presentation of intracellular antigens. It binds to the TCR (signal 1) and activated T cells with the B7-CD28 interaction (signal 2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MHCII is on __ cells and is used for __. It binds to ___.

A

MHCII is on APCs, B cells and macrophages, and is used for presentation of extracellular antigens. It binds o the TCR (signal 1) and activates the presenting cell (most notable B cells) with the CD40L-CD40 interaction (signal 2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD21 is the receptor for

A

EBV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD56 marks

A

NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Two cells express both CD40 and B7, they are

A

Macrophages and B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CD16 is a

A

receptor for Fc of IgG on NKs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Bugs that make superantigens

A

S. Pyo

S. Aureus

17
Q

Macrophages can be directly stimulated by:

via:

A

endotoxins and LPS

via TLR4 and CD14

18
Q

CD14 is a

A

receptor on macrophages that allows for direct stimulation by endotoxins and LPS
AKA TLR4

19
Q

Bugs that use antigenic variation to evade immune system

A 
salmonella (flagella)
borrelia recurrentis 
n. gonorrhoeae (pilus protein)
HIV
HCV
Flu
Trypanosomes
20
Q

Live attenuated polio vaccine

A

Sabin

21
Q

Inactivated/killed polio vaccine

A

Salk

22
Q

Live vaccines

A 
Measles
Mumps
Rubella
Sabin Polio
Influenza (intranasal)
Varicella
Yellow Fever
23
Q

Inactivated/Killed vaccines

A

Rabies
Influenza (injection)
Salk Polio
Hep A

24
Q

Aldesleukin

A

used in renal cell carinoma and metastatic melanoma

25
Q

epoetin alfa

A

aka epo, used for anemias esp in renal failure

26
Q

filgrastim

A

g-csf, usef for bone marrow recovery

27
Q

sargramostim

A

gm-csf, used for bone marrow recovery

28
Q

ifn alpha

A

chronic Hep B or C, Kaposi sarcoma, malignant melanoma

29
Q

Ifn Beta

A

MS

30
Q

IFN gamma

A

CGD

31
Q

Romiplostim and eltrombopag

A

tcp

32
Q

oprelvekin

A

tcp

33
Q

Cyclosporine and Tacrolimus

A

Calcineurin inhibitors that block IL2 transcription

  • Cyclosporine binds cyclophilin
  • Tacrolimus binds FKBP
  • Both are nephrotoxic, neurotoxic
  • Cyclosporine induces hyperlipidemia and gingival hyperplasia/hirsutism
  • Tacrolimus induces DM risk
34
Q

Sirolimus

A

MTOR inhibitor that blocks IL2 Response

  • Insulin resistance
  • hyperlipidemia
  • NOT nephrotoxic
  • synergistic with cyclosporine

Step Study Notes (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions