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Hematology > Pathology > Flashcards

Pathology Flashcards

1
Q

gene rearrangement for Burkitt lymphoma

A

myc/IgH gene rearrangement [t(8;14)]

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2
Q

importance of pluripotent stem cells

A

able to self-replicate or differentiate

source of all hematopoeitic cells

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3
Q

causes of leukemia (environmental)

A 
industrial chemical exposure
cancer chemotherapy
radiation injury
inherited genetic instability
transforming virus
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4
Q

what changes in the cell causes leukemia

A

genetic mutation, translocation, different expression of critical genes

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5
Q

what does a therapy need to target in order to be curative

A

cancer stem cells

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6
Q

why does cancer heterogeneity develop over time

A

chromosomal instability

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7
Q

how to classify leukemia

A

morphologic criteria
cytochemical stain
monoclonal surface markers
chromosomal abnormalities

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8
Q

CD34 marks

A

myeloid stem cell

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9
Q

CD33 marks

A

myeloid blast and promyelocytes

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10
Q

CD14 and CD11b mark

A

monocytic cells

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11
Q

good prognostic factors in AML

A

8:21, 15;17, inv 16

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12
Q

t(15;17) translocation is characteristic for

A

acute promyelocytic leukemia

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13
Q

what is AML sensitive to

A

all-transretinoic acid

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14
Q

CML chromosomal abnormality

A

9;22 reciprocal translocation

produced Bcr/abl gene in pluripotent stem cell

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15
Q

what does the Bcr/abl gene do?

A

drives proliferation of myeloid cell line, increased survival, abnormal adhesion

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16
Q

define blast crisis

A

80% myeloid

20% lymphoid

17
Q

markers of immaturity

A

CD34, TdT

18
Q

T cell lineage markers

A

CD 2, 3, 4, 5, 7, 8

19
Q

B cell lineage markers

A

CD19, 20

Hematology (6 decks)

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