Hematopoeisis

Question 1

lifespan of neutrophils

Answer 1

1-2 days

Question 2

lifespan of RBC

Answer 2

120 days

Question 3

lifespan of platelets

Answer 3

8-9 days

Question 4

factors for inducing neutrophil development

Answer 4

CM-CSF, G-CSF, IL3

Question 5

RBC factor (hormone)

Answer 5

Epo- from the kidney

Question 6

Plt factor

Answer 6

TPO = thrombopoietin- from the liver

Question 7

when does the liver do hematopoeisis

Answer 7

1-9 months of gestation (+ ~3 months after birth)

Question 8

what else controls hematopoeisis in fetal life

Answer 8

yolk sac
liver
spleen
bone marrow

Question 9

where is red marrow located

Answer 9

ribs, vertebrae, pelvis

Question 10

where is yellow marrow located

Answer 10

long bones- arms and legs

Question 11

when is yellow converted to red marrow

Answer 11

in situations of blood loss/trauma

Question 12

osteoblastic/periarteriolar niches

Answer 12

quiescent stem cells

resistant to 5FU

Question 13

perisinusoidal niches

Answer 13

cycling stem cells

killed by 5FU

Question 14

what anchors cells in the niche?

Answer 14

c-kit, integrins, other surface molecules

Question 15

what causes eosinophilic-looking RBC’s

Answer 15

Hb accumulation

Question 16

normal retic count

Answer 16

1-2% of RBC’s

Question 17

how long for RBC maturation

Answer 17

7 days

Question 18

when are retics normally increased (physiologically appropriate)

Answer 18

in bleeding or hemolysis

Question 19

where do T cells mature

Answer 19

thymus

Question 20

where do B cells mature

Answer 20

germinal centers of lymphoid follicles

Question 21

platelet alpha granules

Answer 21

PDGF, platelet factor 4, clotting factors

Question 22

which lineages involve FOG and GATA-1

Answer 22

erythroid and megakaryocytic lineages.

they are transcription factors

Question 23

proto-oncogenes promote

Answer 23

high proliferation

tissue growth

Question 24

examples of proto-oncogenes

Answer 24

Ras, Wnt, Myc, Shh, Notch

Question 25

tumor suppressor genes promote

Answer 25

low proliferation

sensecence and aging

Question 26

examples of tumor suppressor genes

Answer 26

p53, Rb, BRCA

Question 27

small intestine has robust activation of ___ and low expression of ___

Answer 27

p53 pathway

Bcl2

Question 28

colon has high levels of

Answer 28

Bcl2

Question 29

what about melanocytes causes greying of hair?

Answer 29

premature differentiation after DNA damage leading to depletion

Question 30

dyskeratosis congenita
cell aging
BM failure
cancer
are all consequences of...

Answer 30

telomere shortening and genetic instability