Pathology 3 4 5

Question 1

Reversible Macro

Question 2

Reversible Micro

Question 3

Reversible EM

Question 4

What is necrosis?

Question 5

Coagulative necrosis

Question 6

Liquefactive necrosis

Question 7

Caseous necrosis

Question 8

Fat necrosis

Answer 8

Fat destroyed through lipases
appear as chalky white areas

Question 9

Fibrinoid necrosis

Question 10

Neutrophil

Answer 10

System? Innate

Lobes: 2-5

Phagocyte

Migrate through interstitial tissue: Role of chemokine, multistep process

predominate during the first 6-14 hours

Question 11

Monocyte

Answer 11

System? Innate

Bean-shaped nucleus, unilocular

change into macrophages after entering tissue spaces

phagocytosis

replaces neutrophils in 24-28 hours

Question 12

Chemical Mediators of Inflammation

Answer 12

Vasoactive amines (histamine, serotonin)

Complement and kinin systems

Clotting system

Arachidonic acid metabolites (prostaglandins, leukotrienes, lipoxins)

IFN-gamma by NK cells and T lymphocytes

ROIs, NO, lysozymes, free O2 radicals

Question 13

How do we terminate the acute inflammatory response?

Answer 13

Chemical mediators have short half lives

Stop signals: arachidonic acid metabolites will become anti-inflammatory

secretion of TGF beta
inhibition of TNF

tissue macrophages have a prolonged half-life (months or years)

Question 14

Morphologic patters of acute inflammation

Answer 14

1. Serous inflammation (skin blister)
2. Fibrinous inflammation, following severe vascular modification, associated with secondary fibrosis
3. Suppurative inflammation (acute appendicitis)
4. Ulcer (peptic ulcer)