Pathology Flashcards
What happens to the CBC in acute blood loss anemia?
There are proportional decreased in blood count, including WBC and platelets.
What happens to reticulocyte production in acute blood loss? Does it increase or decrease?
Increases
This is the condition where there are premature destruction of RBC’s, ↑ EPO levels, and accumulation of Hb degredation products.
Hemolytic anemia
Is there more unconjugated or conjugated forms of bilirubin in hemolytic anemia?
Unconjugated
since theres an overload of Hb that can’t all be conjugated imemdiately
What happens to the levels of erythroid precursors/normoblasts in the marrow in hemolytic anemia?
Normoblasts ↑
This is the hemolysis of RBC’s within vessels.
Intravascular hemolysis
What is the protein responsible for picking up free Hb?
Haptoglobin
When haptoglobin’s reserves are depletes, what will the rest of the free Hb eventually be oxidized to?
Methemoglobin
So in intravascular hemolysis, what happens to the following values?
Blood Hb
Urine Hb
Urine hemosiderin
Blood haptoglobin
Blood Hb ↑ (hemoglobinemia)
Urine Hb ↑ (hemoglobinuria)
Hemosidinuria
↓ serum haptoglobin
If there is hemolysis in places other than the vessels, what is that condition called?
Extravascular hemolysis
What is the main organ that causes extravascular hemolysis?
Spleen’s sinusoids
Why would the spleen be a little biatch and break down RBC’s? What might be wrong with the RBC’s?
the RBC’s can become less deformable –> get stuck in the spleen sinusoids –> get phagocytoses and broken down
What happens to the gross spleen in extravascular hemolysis diseases?
Splenomegaly
This is an inherited defect int eh RBC cytoskeleton (tethering proteins) which causes weird RBC shapes and extravascular hemolysis?
Hereditary spherocytosis
What are the 3 main proteins affected by hereditary spherocytosis?
Spectrin
Ankyrin
Band 3.1
If theres loss of cytoskeletal proteins in herediatry spherocytosis, what might happen to the the SHAPE of the RBC?
It causes it to be spheres (lol it’s in the name) instead of disc-shaped
If there are sphere-shaped (pac man ghost shaped) RBC’s in hereditary spherocytosis, what happens in the spleen?
They can’t get through the sinusoids –> consumed by splenic marophages –> anemia
What happens to the color of the RBC’s in herediatary spherocytosis?
They lose their central pallor (cuz they’re all big and fat)
What happens to the RDW levels and MCHC levels in hereditary spherocytosis?
RDW ↑
MCHC ↑
What are the clinical manifestations of herediatary spherocytosis?
Splenomegaly
Jaundice with unconjugatted bilirubin (like any other hemolysis)
Biliribin gallstones
What is the test u should do to test for hereditary spherocytosis?
Osmotic fragility test
What is the 1 treatment for hereditary spherocytosis?
Splenectomy
After the splenectomy in hereditary spherocytosis, what might still appear in RBC’s on blood smear?
Howell Jolly bodies
fragments of nuclear material
This is a XR disorder wher ethe HMP shunt or glutathione metabolism are problematic.
G6PD deficiency