Pathology

Question 1

pathology of acute respiratory distress syndrome

Answer 1

increased permeability of alveolar capillaries leading to extracellular fluid accumulation in the alveoli

Question 2

neutrophil chaemotaxis and sloughing of alveolar endothelium

Answer 2

ARDS

Question 3

how is alpha-1-antitrypsin inherited?

Answer 3

autosomal recessive, co-dominant
chromosome 14

Question 4

pathophysiology of alpha-1-anti trypsin

Answer 4

lack of inhibition of trypsin which results in neutrophil elastase overactivity
(alpha-1-antitrypsin inhibits trypsin which is an enzyme that inhibits neutrophil elastase. neutrophil elastase breaks down proteins in the interstitium).

Question 5

patients with alpha-1-antitrypsin mutation, which allele will most likely inherit the condition?

Answer 5

PiZZ