Pathology Flashcards
What is the differential for small round blue cells seen on histology
ARSEPWMN
A - Acute leukaemia
R - rhabdomyosarcoma
S - Small cell lung cancer
E - Ewings sarcoma
P - PNET
W - Wilms tumour
M - Medulloblastoma
N - neuroblastoma
What tumours tend to be CK7- & CK20+
CK7-/CK20+ colorectal adenocarcinoma
What tumours tend to be CK7+ & CK20-
CK7+/CK20- “BBTSEX” = Breast, Bronchus (NSCLC), Thyroid, Salivary, Endometrial, Cervix
What tumours tend to be CK7- & CK20-
CK7-/CK20- HCC, RCC, prostate, SCLC & neuroendocrine tumours
What tumours tend to be CK7+ & CK20+
CK7+/CK20+ TCC bladder, pancreas, mucinous ovarian
What tumours are typically CK20+ / CK7+
What other markers can be included
Bladder
Biliary
Urothelin - TCC
WT1 - primary ovarian cancers
What tumours are typically CK20+ / CK7-
What other markers can be included
Colorectal
Mucinous ovarian
Merkel cell
CEA
CDX2
What tumours are typically CK20- / CK7+
What other markers can be included and what do they indicate
NSCLC and mesothelium
Breast
Thyroid
Serous ovarian
Endometrial
Biliary
TTF1 (lung and thyroid)
ER/PR - breast
GCDFP - breast
GATA3 - breast
CK19 (cholangio & pancreatic)
What tumours are typically CK20- / CK7-
What other markers can be included
SCLC
Squamous cell
Melanoma
liver
Prostate and renal
Cervix
Neuroendocrine
Hep-Par1 - HCC
PSA
CK5/6 - associated with squamous cell carcinoma and malignant mesothelioma
PAX8 - RCC & epithelial ovarian
S100 - melanoma
What histology would PAX8 positivity suggest
Renal
What does CK5/6 indicate
Squamous carcinoma
What does AE1/3 indicate
Positive = carcinoma
If no - melanoma, lymphoma, sarcoma
what is the 10yr OS of thymic carcinoma
29%
What is the rate of myasthenia with thymoma
30%, 70% improve after surgery
send AChR antibodies, serum electrophoresis (hypogammaglobulinaemia) and ANA (polymyositis and dematomyositis)
