Pathologies Flashcards
1
Q
Achlorydia
A
- When gastric pits are destroyed
- Associated with a lack of intrinsic factors - pernicious anaemia
- Iron deficiency anaemia because lack of acids results in ingested iron being retained in an unabsorbable form
2
Q
Pernicious anaemia
A
- Vitamin B12 deficiency - this results from disorders of the stomach mucosa that release intrinsic factor
- Autoimmune destruction of parietal cells
- Crohn’s disease that affects the terminal ileum where B12 is absorbed
3
Q
Iron deficiency anaemia
A
- body has a small store of iron that needs to be frequently replenished to promote adequate haemoglobin synthesis and RBC function
- Iron is absorbed mainly as haem and as ferrous Fe2+
- Fe2+ is oxidised to 3+ by pH of 7.4 the acidity of the stomach prevents this and mantains it in the absorbable form
- PPIs affect the acidity of the stomach may result in iron deficiency anaemia
4
Q
A