pathologic RBC forms

Question 1

acanthocytes

Answer 1

liver disease
abetalipoproteinemia
states of cholesterol dysregulation

Question 2

basophilic stippling

Answer 2

lead poisoning

Question 3

degmacyte is what?

Answer 3

bite cell

Question 4

degmacyte/bite cell

Answer 4

G6PD deficiency

Question 5

elliptocyte

Answer 5

hereditary elliptocytosis

Question 6

macro-ovalocyte

Answer 6

megaloblastic anaemia (also wtih hypersegmented PMNs)
marrow failure

Question 7

ringed sideroblasts

Answer 7

sideroblastic anaemia

excess Fe in mitochondria

Question 8

schistocytes/helmet cell

Answer 8

DIC
TTP
HUS
HELLP syndrome
mechanical hemolysis (heart valve prosthesis)

Question 9

sickle cell

Answer 9

sickle cell anaemia

Question 10

when do sickle cells sickle

Answer 10

dehydrated, deoxygenation, high altitude

Question 11

spherocytes

Answer 11

hereditary spherocytosis

drug and infection induced hemolytic anaemia

Question 12

what is a dacrocyte?

Answer 12

teardrop cell

Question 13

dacrocyte vrs degmacyte

Answer 13

dacrocyte - teardrop - bone marrow infiltration, myelodibrosis
degmacyte - bite cell - G6Pd def

Question 14

target cell

Answer 14

HbC
asplenia
liver disease
thalassemia
HALT

Question 15

liver disease

Answer 15

target cells and acanthocytes

Question 16

abetalipoproteinemia

Answer 16

acanthocyte

Question 17

cholesterol dysregulation

Answer 17

acanthocyte

Question 18

lead poisoning

Answer 18

basophilic stippling and sideroblast

Question 19

G6PD def

Answer 19

bite cells, degmacyte

Question 20

hereditary elliptocytosis

Answer 20

elliptocyte

Question 21

megaloblastic anaemia

Answer 21

macro-ovalovyte

\hypersegmented PMNs

Question 22

hypersegmented PMNs

Answer 22

megaloblastic anaemia

Question 23

marrow failure

Answer 23

macro-ovalocyte

Question 24

DIC, TTP/HUS, HELLP syndrome

Answer 24

shistocytes/helmet cell

Question 25

sickle cell disease

Answer 25

sickle cell

Question 26

hereditary spherocytosis

Answer 26

sperocyte

Question 27

drug induced hemolytic anaemia

Answer 27

spherocyte

Question 28

infection induced hemolytic anaemia

Answer 28

spherocyte

Question 29

bone marrow infiltration

Answer 29

dacrocyte/teardrop cell

Question 30

myelofibrosis

Answer 30

dacrocyte/teardrop cell

Question 31

HbC

Answer 31

target cell

Question 32

asplenia

Answer 32

target cell

Question 33

liver disease

Answer 33

target cell | acanthocytes

Question 34

thalaseeia

Answer 34

target cells

Question 35

what are heinz bodies

Answer 35

oxidation of Hb-SH groups to S-S = Hb precipitation

Question 36

what happens to heinz bodies

Answer 36

oxidized hb precipitated = phagocytic damage to RBC membrane - G6PD def = bite cells/degmacyte

Question 37

heinz body like inclusiosn ?

Answer 37

alpha thalassemia

Question 38

what are howell jolly bodies

Answer 38

basophilic nuclear remnants found in RBCs

Question 39

what is the fate of howell jollly bodies?

Answer 39

howell jolly bodies - nuclear remnants in RBCs are normally removed from RBCs by splenic macrophages

Question 40

where do you see howell jolly bodies

Answer 40

seen in patients with fucntional hyposlepina or asplenia

Question 41

functional hyposplenia or asplenia

Answer 41

howell jolly bodies