Pathogens

Question 1

5 facts about pseudomonas aeruginosa?

Answer 1

1. gram -, highly motiles, bacterial rod
2. Adheres tightly to lung epithelim via pili
3. Flagella promot adherence and motility
4. produce alginate (mucoidy) film/capsule
5. CF patient suspetible

Question 2

What are 5 facts about S. pyogenes?

Answer 2

1. Gram +, cocci in chains, beta hemolytic, bactracin sensitive, catalase negative
2. natural inhabitant of skin and throat, can inhale droplets, contact with fomites on surfaces
3. Step throat, impetigo, necrotizing skin fasciitis
4. Scarlet fever, toxic shock
5. Acute Rheumatic fever or Acute glomerulonephritis if not treated with abx in 2-5 weeks

Question 3

What are 6 virulence factors of S. pyogenes?

Answer 3

1. attachment proteins that bind to extracellular matrix proteins
2. produce degradative enzymes (DNase, hyaluronidase)
3. produe streptokinase that dissolves closts
4. Produces pore forming toxins (Streptolysin)
5. produce PAMPs and superantigens
6. Have hyaluronan capsule and M proteins (cross reactive so prevent phagocytosis/complement system)

Question 4

What are 2 facts about S. agalactiae?

Answer 4

1. Gram + beta, beta hemolytic, bactracin resistant
2. cause meningitis, pneumoniam sepsis in neonates so should screen pregnant women