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Perio 1 > Pathogenesis of Periodontal Disease 2 > Flashcards

Pathogenesis of Periodontal Disease 2 Flashcards

1
Q

WHat need to happen in order for you to get initial periodontitis?

A

bacterial penetration

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2
Q

WHat need to happen in order for you to get initial periodontitis?

A

bacterial penetration

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3
Q

What percentage of IgG

A

80%

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4
Q

What percentage of IgM

A

5%

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5
Q

What percentage of IgA

A

10%

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6
Q

WHat percentage of IgD

A

<1%

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7
Q

What percentage of IgE

A
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8
Q

IgG function

A

Agglutination
Opsonization
Complement Fixation

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9
Q

IgM Function

A

Agglutination

Complement fixation that leads to opsonization

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10
Q

WHat is the first antibody produced during immune reponse?

A

IgM

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11
Q

IgG properties

A

Specific attachment to phagocytes

Crosses placenta

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12
Q

IgA Function

A

Protection of mucous membranes

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13
Q

WHere is IgA secreted into

A

Secreted into saliva milK mucus

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14
Q

IgD funtions

A

Facilitates development of antibdy response

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15
Q

IgD properties

A

Antigen receptor on B lymphocytes

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16
Q

IgE function

A

Involved in allergic rxns

Helps expel parasites

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17
Q

IgE properties

A

Attaches to mast cells
Attaches to basophils
ANtigen reacts with cell IgE to release granules

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18
Q

Where are the hypervariable regions?

A

All accross variable region on both HC and LC

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19
Q

What happens in primary response against new antigen?

A

IgG and IgM small

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20
Q

4 types of responses against an antigen

A

1) Local
2) Systemic
3) monoclonal
4) Polyclonal

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21
Q

What percentage of IgG

A

80%

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22
Q

What percentage of IgM

A

5%

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23
Q

What percentage of IgA

A

10%

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24
Q

WHat percentage of IgD

A

<1%

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25
Q

What percentage of IgE

A
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26
Q

IgG function

A

Agglutination
Opsonization
Complement Fixation

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27
Q

IgM Function

A

Agglutination

Complement fixation that leads to opsonization

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28
Q

WHat is the first antibody produced during immune reponse?

A

IgM

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29
Q

IgG properties

A

Specific attachment to phagocytes

Crosses placenta

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30
Q

IgA Function

A

Protection of mucous membranes

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31
Q

WHere is IgA secreted into

A

Secreted into saliva milK mucus

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32
Q

An imbalance of CD4 and CD8 cells causes what?

A

periodontal disease

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33
Q

IgD properties

A

Antigen receptor on B lymphocytes

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34
Q

IgE function

A

Involved in allergic rxns

Helps expel parasites

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35
Q

IgE properties

A

Attaches to mast cells
Attaches to basophils
ANtigen reacts with cell IgE to release granules

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36
Q

Where are the hypervariable regions?

A

All accross variable region on both HC and LC

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37
Q

What happens in primary response against new antigen?

A

IgG and IgM small

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38
Q

What happens during secondary response to new antigen?

A

Huge IgG response

Small IgM response

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39
Q

4 types of responses against an antigen

A

1) Local
2) Systemic
3) monoclonal
4) Polyclonal

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40
Q

How long is the half life of macrophage?

A

long

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41
Q

What type of cell is macrophage?

A

mobile

42
Q

What IL activate CD 4?

A 
IL - 1
IL 2
IL 3
IL 4
IL 5
IL 6
IL 9
IL 10
43
Q

APC presents antigen to what?

A

Th cell

44
Q

Genotype positive = what?

A

immune response quicker so periodontal disease quicker

45
Q

SMoking and diabetes casue what?

A

Increase inflammation
increase MMP expression
Concomitant Tissue destruction

46
Q

MHC I is associated with

A

CD8

47
Q

MHC 2 is associated with

A

CD4

48
Q

Activated T cell produce what that causes prolferation of T cell

A

IL - 2

49
Q

Th1 causes what

A

macrophage activation

50
Q

Th2 causes what

A

antbody response

51
Q

An imbalance of CD4 and CD8 cells causes what?

A

periodontal disease

52
Q

What is associated with cell mediated immunity

A

CD8

53
Q

What IL stimulates growth of mast cells

A

IL 3
IL 4
IL 9

54
Q

NUP means what

A

Necrotizing ulcerative periodontitis

55
Q

Clinical features of NUG, NUP and HIVP

A

Spontaneous bleeding
Necrosis
Edema
Extremely rapid bone loss

56
Q

Cytokines Def

A

Low molecular weight proteins that mediate interactions b/w lymphocytes and inflammatory cells

57
Q

Most cytokines are referred to as

A

Interlukins

58
Q

Can cytokines elicit different biological responses from different cells?

A

True!

59
Q

What is the only IL that is pleomorphic?

A

IL - 1

60
Q

What IL includes Osteoclast (OAF) and Lymphocyte (LAF) activities

A

IL 1

61
Q

What IL activate CD 4?

A 
IL - 1
IL 2
IL 3
IL 4
IL 5
IL 6
IL 9
IL 10
62
Q

What IL helps B cells mature

A

IL 1

63
Q

What IL is tied to PMN and macrophage chemotaxis

A

IL 1

64
Q

What IL increases NK cell activity, fibroblast procollagen, PGE2 and bone resorption?

A

IL 1

65
Q

What IL is secreted by monocytes, macrophages, B cells, fibroblasts, PMNs, epithelial cells

A

IL 1

66
Q

What IL is found in gingival tissues, GCF

A

IL 1

67
Q

What IL decreases after periodontic treatment?

A

IL 1

68
Q

What IL stimulates Macrophages and NK function

A

IL 2

69
Q

What IL is secreted by NK cells

A

IL 2

IL 3

70
Q

What IL increases in tissues with periodontitis

A

IL 2
IL 1
IL 4

71
Q

What Il stimulates PMN MMP actiivity

A

IL 8

72
Q

What IL stimulates growth of mast cells

A

IL 3

IL 4

73
Q

What IL is involved in b cell activation and differentiation

A

IL 4

IL 5

74
Q

What IL is involved in T cell growth

A

IL 4

75
Q

What IL is involved in histamine secretion

A

IL 3

76
Q

What IL is involved in IgE synthesis

A

IL 4

77
Q

What IL enhances IgA production

A

IL 5

78
Q

What IL stimulates plasma cell production

A

IL 6

79
Q

What IL partners with IL 1 to activate CD 4

A

IL 6

80
Q

What IL is secreted by Macrophages, monocytes, fibroblasts and endothelial cells

A

IL 6

81
Q

What IL increases in sites of gingival inlfammation

A

IL 6

82
Q

What IL plays a role in bone resorption

A

IL 6

83
Q

What IL induces T cell proliferation by expressin IL 2 and IL 2 receptors

A

IL 7

84
Q

What Il is secreted by bone marrow stromal cells

A

IL 7

85
Q

What IL is chemotactic for PMNs

A

IL 8

86
Q

What IL increases PMN adherance to endothelial cells

A

IL 8

87
Q

What IL is secreted by macrophages in response to IL1 and TNF - alpha

A

IL 8

88
Q

What IL os present in high levels in perio lesions associated with JE and macrophages

A

IL 8

89
Q

What IL is high in disease vs health

A

IL 8

90
Q

What Il stimulates PMN MMP actiivity

A

IL 8

91
Q

What Il induces proliferation if CD4 cells in absence of antigen

A

IL 8

92
Q

What IL inhibits/turns off the antigen presenting capacity of monocytes

A

Il 10

93
Q

IFNs function

A

1) antiviral activity
2) Enchance macrophage, T cell and NK activity
3) Inhibits osteoclasts thus playing role in bone resorption

94
Q

TNF function

A

1) Cause necrosis in some tumors
2) TNF alpha and beta can activate osteoclasts leading to bone resorption
3) TNF alpha increases PMN adherance to endothelial cells

95
Q

TNF beta releases what?

A

Lymphotoxin

96
Q

When is TNF alpha produced?

A

After stimulation of macrophages by LPS

97
Q

TNFa functions

A

1) alpha increases PMN phagocytosis and chemotaxis

98
Q

Plaque antogens favor TNFa beta or direct lymphotoxcity leading to what?

A

tissue damage seen in periodontal disease

99
Q

TNFa beta is cytotoxic for what

A

fibroblasts

100
Q

IL 1 lowers this systemic effect

A

Neutrophil superoxide stimulation

Perio 1 (5 decks)

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