Pathogenesis of Autoimmune Disease: part 1 Flashcards
Define Ankylosing Spondylitis.
Chronic spinal inflammation that can result in fusion and deformity
What family of diseases is ankylosing spondylitis a part of?
Seronegative spondyloarthropathies
Define Systemic Lupus Erythematosus (SLE).
Chronic tissue inflammation in the presence of antibodies directed at self-antigens NOTE: it is inflammation of sterile tissue
A change in which class of MHC is associated with rheumatoid arthritis, ankylosing spondylitis and SLE?
Ankylosing spondylitis = Class 1 Rheumatoid Arthritis + SLE = Class 2
Lupus causes multi-site inflammation but state some sites that are particularly badly affected.
Joints, Skin and Kidneys
What are the two main autoantibodies that are associated with rheumatoid arthritis?
Rheumatoid factor Anti-cyclic citrullinated peptide antibody
What is the site of inflammation in ankylosing spondylitis?
Entheses – where a ligament or a tendon inserts into bone
On which chromosome is HLA encoded?
Chromosome 6
What other diseases are part of this family?
Systemic sclerosis (diffuse and localised) Polymyositis/Dermatomyositis Sjogren’s syndrome Mixed connective tissue disease
What family of diseases is lupus a part of?
Connective tissue diseases
Other than at joints, where else is synovium found?
Around tendons (tenosynovium)
Which cells express class I MHC and which cells recognise this class of MHC?
All nucleated cells (they display endogenous antigens) They are recognised by CD8+ T cells
What is Sjogren’s syndrome?
An autoimmune disease that targets the exocrine glands (e.g. lacrimal glands)
Which other diseases fall into this family of diseases?
Reiter’s syndrome and reactive arthritis Psoriatic arthritis Enteropathic synovitis
Define Rheumatoid Arthritis.
Chronic autoimmune disease characterised by pain, stiffness and symmetrical synovitis of synovial joints
