NPR Flashcards
Describe the skin changes that take place in dermatomyositis.
Lilac rash on eyelid, malar region and naso-labial folds Red or purple lesions on knuckles (Gottron’s papules) Subcutaneous calcinosis Mechanic’s hands (fissuring and cracking of the skin over the finger pads)
What is the key autoantibody in: a. Diffuse systemic sclerosis b. Limited systemic sclerosis c. Dermatomyositis/Polymyositis d. Mixed connective tissue damage
a. Diffuse systemic sclerosis Anti-Scl-70 antibody b. Limited systemic sclerosis Anti-centromere antibody c. Dermatomyositis/Polymyositis Anti-tRNA transferase antibody d. Mixed connective tissue disease Anti-U1-RNP antibody
State some important cytokines in rheumatology.
IL-1 – produced by macrophages and activates T cells, fever + pro-inflammatory IL-2 – produced by T cells – activates T + B cells IL-6 – produced by T cells – activates B cells + acute phase response TNF-alpha – produced by macrophages – similar to IL-1 but more destructive Gamma-IFN – produced by T cells – activates macrophages
What can upregulate RANKL production?
IL-17 IL-1 TNF-alpha PTH-related peptide
State two drugs that deplete B cells and specify what they target.
Rituximab – anti-CD20 monoclonal antibody Belimumab – anti-BLYS monoclonal antibody (BLYS is a B cell survival factor)
What do glucocorticoids inhibit?
Phospholipase A2
What are the MHC associations of rheumatoid arthritis, ankylosing spondylitis and SLE?
Rheumatoid arthritis – HLA-DR4 SLE –HLA-DR3 Ankylosing spondylitis – HLA-B27
A change in which class of MHC is associated with rheumatoid arthritis, ankylosing spondylitis and SLE?
Ankylosing spondylitis = Class 1 Rheumatoid Arthritis + SLE = Class 2
What are the MHC associations of rheumatoid arthritis, ankylosing spondylitis and SLE?
Rheumatoid arthritis – HLA-DR4 SLE –HLA-DR3 Ankylosing spondylitis – HLA-B27
