Patho week 2 Flashcards
In pharmacokinetics what does ADME mean?
Absorption
Distribution
Metabolism
Excretion
What in pharmacokinetics is the movement from site of administration into blood stream?
Absorption
What in pharmacokinetics is transport through systemic circulation to target tissue/organs and cells?
Distribution
What in pharmacokinetics is the chemical alteration of drugs to make it pharmacologically active?
Metabolism
What in pharmacokinetics is the removal of drugs and metabolites from the body?
Excretion
Explain agonist, partial agonist and antagonist
Agonist - mimics body own messengers
Partial agonist - produce weaker response than agonist
Antagonist - bind to receptor and block it
What is the therapeutic index of pharmacodynamics?
TD50 / ED50 = TI or measures of safety
– medication closer to 1 or more narrow are more dangerous
What is an effect that is the opposite of the intended drug response?
The paradoxical effect
What is an uncommon drug response resulting from genetic predisposition?
Idiosyncratic effect
What is a disease that occurs as the result of medical care or treatment and is nearly identical io idiopathic diseases.
Iatrogenic diseases
What is the ability of certain medications and environmental chemical to cause cancers?
Carcinogenic effect
What is a drug induced birth defect?
Teratogenic effect
