patho test #1 drugs Flashcards
opioid agonist analgesics
binds to opioid receptor and causes an analgesic response
opioid agonist analgesics indication
moderate to severe pain
opioid agonist analgesics top 3 worries
CNS/resp depression, constipation, urinary retention
opioid agonist analgesics side effects
nausea due to CTZ, histamine release which can cause itching, and strong abuse potential
MS contin
ER form of morphine
morphine sulfate class
opioid agonist analgesic
morphine sulfate nursing considerations
Hypotension and caution with renal disease because it has a metabolite that the kidney needs to get rid of.
hydromorphone is also called
dilaudid
1 mg dilaudid = how many mg morphine
7 mg
exalgo
ER of dilaudid
can you give dilaudid to a kidney pt
yes
fentanyl
very strong opioid
what can you not do to a fentanyl patch
expose it to heat or cut it because1 both can accelerate the diffusion of the drug
who do you want to be mindful with in giving opioids
geriatric population
indication of fentanyl
pain control, balance anesthesia, conscious sedation
fentanyl patches
for chronic pain management and can be used for 72 hours
can you give opioid naive patients fentanyl patches
no only for opioid tolerant because it is like having 8 mg dilaudid or 60 mg of morphine
IV fentanyl considerations
comes in a glass container so need to use a filtered needed to suck up
Percocet
oxycodone with acetaminophen
percodan
oxycodone with aspirin
oxycontin
sustained release of oxycodone
how long does oxy IR take to work
10-15 min
Norco
hydrocodone with acetaminophen
is oxy or hydrocodone weaker
hydrocodone
if patient have liver disease we don’t want them have more than ______ Tylenol
2000 mg
which opioid is a cough suppressant
hydrocodone
methadone hydrochloride is also called
dolophine
how long of duration does methadone have
long - 24-48 hours
methadone indication
cancer, chronic back pain, treatment for addicts,
methadone onset
30-60 min
where is methadone absorbed
GI tract
methadone half life
longer than its duration because as you repeat dose it accumulates in the tissues and is slowly released thus allowing for 24 hour dosing
where is methadone eliminated from
the liver so it is a safer choice than others for renal impaired pt
concerns with methadone
cardiac dysrhythmia with prolonged QT interval so should not be given to pt with cardiac history
opiate antagonist
CNS stimulator and reverses opioids
example of opiate antagonist and what else is it called
naloxone also called narcan
naloxone has a higher affinity for
Mu receptor
indication of naloxone
opioid OD such as respiratory depression
adverse effects of naloxone
opioid withdrawal
half life and duration of naloxone
has a short half life with a duration of 0.5-2 hour
nursing considerations for naloxone
rebound toxicity
what could happen after giving naloxone
ventricular tachycardia if you are giving it to someone addicted to opioids. opioid withdrawal
osmotic diuretics nursing considerations
can crystallize in low temp, so store in warmer. in glass vial so always use filter needle. visually inspect for precipitants
what do osmotic diuretics do
increase osmotic pressure in glomerulus and bring fluid in from interstitial space
where does osmotic diuretics work
along entire nephron so it causes a major impact
osmotic diuretics example
manitol
osmotic diuretic indication
cerebral edema from trauma, AKI, oliguric phase, increased renal blood flow. promotes excretion of toxins
when is osmotic diuretics not indicated
peripheral edema or chronic heart failure
are osmotic diuretics absorbable or nonabsorbable
non absorbable so decreases cellular edema
if loop diuretics are pushed too fast what can happen
can cause permanent hearing loss so control rate
what does the patient need to be on if on loop diuretics
potassium supplement
how do loop diuretics work
activate renal prostaglandins which causes vessel dilation in the kidney, pulmonary, and systemic and causes a decrease in preload and central venous pressure
indication of loop diuretics
pulmonary edema, HTN, renal/hepatic/cardiac failure