Patho Exam 2 Hypertension Flashcards

1
Q

What are the four factors that increase blood pressure?

A

increased CO
increased blood viscosity
increased vascular resistance
increased sympathetic signals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Four hormones that increase blood pressure

A

epi, norepi, AHD, and angiotension II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How do epi and norepi increase BP?

A

increased cardiac output and causes vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How does ADH increase BP?

A

vasoconstriction increased salt and water reabsorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How does angiotension II cause increased BP?

A

causes vasoconstriction of arterioles and causes aldosterone secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which hormones decrease BP?

A

Atrial natriuetic peptide
histamine
Nitric oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does ANP reduce BP?

A

causes vasodialation and promotes salta and water loss in urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does histamine reduce BP?

A

vasodilation of arterioles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does nitric oxide reduce BP?

A

vasodilation of arterioles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the funtion of baroreceptors and where are they?

A

Located in aortic arch and carotid sinus
Maintain BP by sensing stretch of artery. When BP is low, baroreceptors send a signal to the brain to signal to the B1 and alpha receptors. B1 increase CO and Alpha cause vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What damage does HTN cause for the heart?

A

left ventricular hypertrophy
angina or myocardial infarction
coronary revascularization
heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What damage does HTN cause for the brain?

A

stroke or TIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What damage does HTN cause for the kidneys?

A

chronic kidney disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What damage does HTN cause for the arteries?

A

peripheral arterial disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What damage does HTN cause for the eyes?

A

retinopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MAP equation

A

MAP= 1/3 systolic + 2/3 diastolic

17
Q

What causes primary HTN?

A

environmental, genetic, and lifestyle factors/unknown

18
Q

What causes secondary hypertension?

A

Caused by conditions that affect the kidneys, arteries, heart or endocrine system. Secondary hypertension can also occur during pregnancy.
ex. diabetes, chronic kidney disease, renal artery stenosis, pheochromocytoma, obesity/sleep apnea

19
Q

What is the first treatment for primary hypertension?

A

lifestyle modifications
weight loss, exercise, DASH diet, decrease alcohol, decrease sodium

20
Q

hypertensive urgency

A

BP of 180/110 or higher but no organ damage. Can be corrected with immediate care and medicine over 24-48 hours

21
Q

hypertensive emergency

A

BP of 180/110 or higher with organ damage. Critical emergency. Can result in stroke, heart attach, aortic dissection, and death.

22
Q

orthostatic hypotension

A

decrease in systolic bp >20mmHg or >10mmHg within three mins when moving to an upright position. Increase of HR by 20-30 bpm may be diagnostic

23
Q

symptoms of orthostatic hypotension

A

dizziness, blurred vision, confusion, and possible syncope

24
Q

What is orthostatic BP associated with?

A

cardiovascular disease and a risk factor for stroke, cognitive impairment, and death.

25
Q

What can cause orthostatic hypotension?

A

issues with baroreceptor or vasomotor response
adverse drug therapy
arterial stiffness
volume depletion
secondary disease process
vasovagal response
cardiac dysrhythmias

26
Q

Orthostatic hypotension treatments

A

slow positional changes
avoid heat
avoid large or high carb meals
increase salt and fluid intake

27
Q

When ace inhibitors are used what are the 4 results?

A
  1. arteriole dilation which improves blood flow to kidneys, decreases renal constriction, reduces afterload, increases stroke volume/CO, and promotes excretion of sodium and water
  2. venous dilation which reduces venous pressure, reduces pulmonary congestion, reduces peripheral edema, and increases preload and cardiac dilation
  3. suppression of aldosterone release
  4. reduced cardiac remodeling
28
Q

pathophysiologic mechanism for hyperkalemia

A

Due to the suppression of aldosterone, K+ is not secreted into the urine

29
Q

What other pre existing conditions or drugs may increase K levels when given with ACEi?

A

naturally higher K+ value
poor renal function
diabetes
K supplements or sparing diuretics
NSAIDs and salt substitutes

30
Q

Ischaemia-Reperfusion injury (IRI)

A

the paradoxical exacerbation of cellular dysfunction and death, following restoration of blood flow to previously ischaemic tissues.

31
Q

What are the 4 B side effects of beta blockers?

A

bradycardia, low BP, low blood glucose, and bronchoconstriction