Patho Flashcards
Oncogene. Burkitt’s lymphoma
c-myc
Oncogene. CML
abl
Oncogene. Follicular and undofferentiated lymphomas
bcl-2
Oncogene. Breast, ovarian andd gastric carcinomas
erb-B2
Oncogene. Colon carcinoma
ras
Oncogene. Lung tumors
L-myc
Oncogene. Neuroblastoma
N-myc
Oncogene. Multiple Endocrine Neoplasia types IIA and IIB
ret
Oncogene. Gastrointestinal stromal tumor
c-kit
Tumor supressor gene. Retinoblastoma, osteosarcoma
Rb
Blocks G1 to S phase of cell cycle
Tumor supressor gene. Most human cancers, Li-Fraumeni syndrome
p53
Blocks G1 to S phase of cell cycle
Tumor supressor gene. Breast and ovarian cancer
BRCA1
Tumor supressor gene. Breast cancer
BRCA2
Tumor supressor gene. Melanoma
p16
Tumor supressor gene. Colorectal cancer
APC
Tumor supressor gene. Wilm’s Tumor
WT1
Tumor supressor gene. Pancreatic cancer
DPC
“Deleted in Pancreatic Cancer”
Tumor supressor gene. Colon cancer
DCC. “Deleted on Colon Cancer”
Tumor Marker. BPH, prostatitis
PSA
Prostate specific antigen
Tumor Marker. Prostate carcinoma
Prostatic acid phosphatase
Tumor Marker. Melanoma, neural tumors, astrocytes
S-100
Tumor Marker. Metastases to bone, Paget’s Disease of Bone
Alkaline Phosphatase
Tumor Marker. Neuroblastoma, lung and gastric cancer
Bombesin
Tumor Marker. Hairy cell leukemia and B cell neoplasm
TRAP
Tartrate resistant acid phosphatase
“Trap the Hairy Animal”
